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Chronological Changes in Genetic Variance and Heritability of Systolic and Diastolic Blood Pressure Among Chinese Twin Neonates

Published online by Cambridge University Press:  01 August 2014

M.-W. Yu ,
C.-J. Chen ,
C.-J. Wang ,
S.-L. Tong ,
M. Tien ,
T.-Y. Lee ,
H.-C. Lue ,
F.-Y. Huang ,
C.-C. Lan  and
K.-H. Yang
...Show all authors
M.-W. Yu
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
C.-J. Chen*
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
C.-J. Wang
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
S.-L. Tong
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
M. Tien
Affiliation:
Institute of Public Health, National Taiwan University College of Medicine, Taiwan, Republic of China
T.-Y. Lee
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
H.-C. Lue
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
F.-Y. Huang
Affiliation:
Mckay Memorial Hospital, Taiwan, Republic of China
C.-C. Lan
Affiliation:
Mckay Memorial Hospital, Taiwan, Republic of China
K.-H. Yang
Affiliation:
Taipei Municipal Maternal and Child Hospital, Taiwan, Republic of China
H.-C. Wang
Affiliation:
Taipei Municipal Maternal and Child Hospital, Taiwan, Republic of China
H.-Y. Shih
Affiliation:
National Nursing School Hospital, Taipei, Taiwan, Republic of China
C.-Y. Liu
Affiliation:
National Nursing School Hospital, Taipei, Taiwan, Republic of China
J.-S. Chen
Affiliation:
National Taiwan University Hospital, Taiwan, Republic of China
*
Institute of Public Health, National Taiwan University College of Medicine, 1, Jen-Ai Road Section 1, Taipei 10018, Taiwan, Republic of China

Abstract

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In order to examine the chronological changes in genetic variance and heritability of arterial systolic and diastolic blood pressure (SBP and DBP) of Chinese infants in Taiwan, a total of 339 same-sexed twin neonates born in four major general teaching hospitals in Taipei City were studied. Based on placentation and 12 red blood cell antigens, 274 monozygotic (MZ) and 65 dizygotic (DZ) twin pairs were identified and followed up to the age of one year. Both SBP and DBP were measured by Doppler blood pressure monitor. Within-pair mean squares of SBP and DBP were consistently smaller in MZ than DZ twins at ages one month and over. The findings remained unchanged after the adjustment for the effects of age, sex, gestational age, placentation and physical state during blood pressure measurement. Falconer's heritability indices for adjusted SBP and DBP at ages two months and over ranged from 0.29 to 0.55 and from 0.27 to 0.45, respectively. The study indicates an important genetic influence on blood pressure during infancy.

Keywords

HeritabilityBlood pressureInfantsTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 1 , January 1990 , pp. 99 - 108
Copyright
Copyright © The International Society for Twin Studies 1990

References

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