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Chromosomes and Natural Selection

Published online by Cambridge University Press:  01 August 2014

L. S. Penrose*
Affiliation:
Galton Laboratory, University College. Gower Street, London W. C. 1. (Great Britain)

Extract

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Gene mutations can be lethal in their effects, they can be mildly disruptive and diminish individual fitness, they can be neutral or even slightly favourable. The same is true for chromosomal aberrations. Consequently, natural selection in populations can be set up by alterations in chromosomal structure just as it is by gene changes which affect the hereditary material of a species. There are, however, important differences in the manner by which selective effects are produced following the various kinds of spontaneous change.

The present paper deals primarily with chromosomal changes but there are two ways in which selection may act on them. First, there is the immediate effect of an aberration upon the fitness of an individual who carries it and which leads to persistence or extinction of that particular aberration. Secondly, there is the less direct effect of an aberration upon the frequency of any gene which may be responsible for inducing it. Study of the immediate effects is comparable to the analysis of the behaviour of mutant genes in populations by classical methods (Fisher 1930, Wright 1931, Haldane 1932). Study of the second, less direct, process is comparable to the analysis of the behaviour of mutagenic genes (mutators).

Type
Simposio II/Symposium II (9 Settembre)
Copyright
Copyright © The International Society for Twin Studies 1962

References

Beadle, G. W., 1932. A sticky chromosome in Zea Mays. Zts. ind. Abstam.- u. Vererbungsl., 63, 195.Google Scholar
Böök, J. A. & Santesson, B., 1961. Nuclear sex in triploid XXY human cells. Lancet, 2, 318.CrossRefGoogle Scholar
Dobzhansky, Th., 1946. Genetic structure of natural populations. Yrbk Carneg. Inst., Wash., 43, 120.Google Scholar
Dunn, L. C., 1960. Variations in the transmission ratios of alleles through egg and sperm in Mus musculus. Amer. Nat., 94, 385.CrossRefGoogle Scholar
Edwards, J. H., 1961. Personal communication.Google Scholar
Ellis, J. R. & Penrose, L. S., 1961. Enlarged satellites and multiple malformations in the same pedigree. Ann. hum. Genet., Lond., 25, 159.CrossRefGoogle ScholarPubMed
Fisher, R. A., 1930. The genetical theory of natural selection. Oxford University Press.CrossRefGoogle Scholar
Fraccaro, M., 1961. Personal communication.Google Scholar
Fraccaro, M., Kaijser, K. & Lindsten, J., 1960. Chromosomal abnormalities in father and mongol child. Lancet, 1, 724.CrossRefGoogle ScholarPubMed
Haldane, J. B. S., 1932. The cause of evolution. London: Longmans, Green & Co.Google Scholar
Haldane, J. B. S. 1938. Congenital disease. Lancet, 2, 1449.CrossRefGoogle Scholar
Haldane, J. B. S. 1941. Selection against heterozygosis in man. Ann. Eugen., Lond., 11, 333.CrossRefGoogle Scholar
Hanhart, E., 1960. 800 Fälle von Mongoloidismus in konstitutioneller Betrachtung. Arch. J. Klaus Stift., 35, 1.Google Scholar
Jacob, F. & Wollman, E. L., 1961. Viruses and genes. Sci. Amer., 204, 93.CrossRefGoogle ScholarPubMed
Penrose, L. S., 1939. Maternal age, order of birth and congenital abnormalities. J. ment. Sci., 85, 1141.CrossRefGoogle Scholar
Penrose, L. S., 1961. Parental age and non-disjunction. Human chromosomal abnormalities, p. 116. London: Staples Press.Google Scholar
Penrose, L. S., Delhanty, J. D. A., 1961. Triploid cell cultures from a macerated foetus. Lancet, 1, 1261.CrossRefGoogle ScholarPubMed
Penrose, L. S., Delhanty, J. D. A., 1961. Familial Langdon Down anomaly with chromosomal fusion. Ann. hum. Genet., Lond., 25, 243.CrossRefGoogle Scholar
Snell, G. D., Bodemann, E. & Hollander, W., 1934. A translocation in the house mouse and its effect on development. J. exp. Zool., 67, 93.CrossRefGoogle Scholar
Sturtevant, A. H., 1929. The “claret” mutant type of D. simulans. A study of chromosome elimination and of cell lineage. Zts. wiss. Zool., 135, 325.Google Scholar
Wright, S., 1931. Evolution in mendelian populations. Genetics, 16, 97.CrossRefGoogle ScholarPubMed