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Chromosomal Evidence of Donor Cells Proliferation following Bone Marrow Transplantation

Published online by Cambridge University Press:  01 August 2014

G. Schwanitz ,
G. Hartwich  and
J. Becker
G. Schwanitz*
Affiliation:
Institut für Humangenetik undAnthropologie der Universität, Erlangen-Nürnberg Medizinische Klinik derUniversität Erlangen-Nürnberg
G. Hartwich*
Affiliation:
Institut für Humangenetik undAnthropologie der Universität, Erlangen-Nürnberg Medizinische Klinik derUniversität Erlangen-Nürnberg
J. Becker*
Affiliation:
Institut für Humangenetik undAnthropologie der Universität, Erlangen-Nürnberg Medizinische Klinik derUniversität Erlangen-Nürnberg
*
Institut für Humangenetik undAnthropologie der Universität Erlangen-Nürnberg, Bismarckstrasse 26/11, 8520 Erlangen, Deutschland
Medizinische Klinik derUniversität Erlangen-Nürnberg, Krankenhausstrasse 12, 8520 Erlangen, Deutschland
Medizinische Klinik derUniversität Erlangen-Nürnberg, Krankenhausstrasse 12, 8520 Erlangen, Deutschland

Summary

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After an intense cytostatic treatment of the patient F.N., whose bone marrow was completely infiltrated with lympho-sarcocytes, a bone marrow transplantation was made. The donor was the patient's sister. The difference in sex chromosomes made it possible to observe the fate of the transferred cells. Immediately after the treatment, till 6½ months later, cells with feminine caryotype were traceable in the patient's peripheral blood (up to 2%). This proves the proliferation of donor cells in the acceptor.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 18 , Issue 2 , April 1969 , pp. 125 - 141
Copyright
Copyright © The International Society for Twin Studies 1969

References

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