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Behavioral Responses to Amphetamines in Identical Twins

Published online by Cambridge University Press:  01 August 2014

John C. Crabbe ,
Lissy F. Jarvik ,
Edward H. Liston  and
Donald J. Jenden
John C. Crabbe*
Affiliation:
Research Service (151), VA Medical Center, Portland, Oregon, and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University
Lissy F. Jarvik
Affiliation:
Psychogeriatric Unit, VA Medical Center, Brentwood, Los Angeles Department of Psychiatry and Biobehavioral Sciences
Edward H. Liston
Affiliation:
Department of Psychiatry and Biobehavioral Sciences
Donald J. Jenden
Affiliation:
Department of Pharmacology, UCLA School of Medicine, Los Angeles
*
Research Service (151P), VA Medical Center, Portland, Oregon 97201, USA

Abstract

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Male, monozygotic twins (six pairs) were repeatedly tested before and after d-amphetamine, l-amphetamine, or placebo administration. Drug effects on cognitive, psychomotor, personality, mood, and pain variables were assessed. Members of a twin pair tended to respond similarly on several tests under placebo conditions, indicating genetic determination of the behavioral variables. In addition, cotwins tended to show similar responses to amphetamine as measured by one test of cognitive function, by several mood and personality variables (hostility, autonomic arousal, friendliness, feelings of tension and loss of control), and tended to have similar plasma levels of both amphetamine isomers. Although shared environmental effects cannot be ruled out, the results are consistent with genetic mediation of a variety of behavioral effects of amphetamines.

Keywords

PsychopharmacogeneticsAmphetaminesPsychopharmacologyBehavioral geneticsTwins
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 32 , Issue 2 , April 1983 , pp. 139 - 149
Copyright
Copyright © The International Society for Twin Studies 1983

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