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Antinuclear Antibody Factors and Nuclear Staining in Mothers of Children Affected with Down's Syndrome

Published online by Cambridge University Press:  01 August 2014

Freddie L. Pollard ,
Steven Zsako ,
Margaret A. Kelsall  and
Arnold R. Kaplan
Freddie L. Pollard*
Affiliation:
Laboratories of Cytology and of Medical Genetics, Cleveland Psychiatric Institute, Cleveland, Ohio; and Department of Medicine, Euclid Clinic Foundation, Euclid, Ohio
Steven Zsako
Affiliation:
Laboratories of Cytology and of Medical Genetics, Cleveland Psychiatric Institute, Cleveland, Ohio; and Department of Medicine, Euclid Clinic Foundation, Euclid, Ohio
Margaret A. Kelsall
Affiliation:
Laboratories of Cytology and of Medical Genetics, Cleveland Psychiatric Institute, Cleveland, Ohio; and Department of Medicine, Euclid Clinic Foundation, Euclid, Ohio
Arnold R. Kaplan
Affiliation:
Laboratories of Cytology and of Medical Genetics, Cleveland Psychiatric Institute, Cleveland, Ohio; and Department of Medicine, Euclid Clinic Foundation, Euclid, Ohio
*
Laboratory of Cytology, Cleveland Psychiatric Institute, 1708 Aiken Avenue, Cleveland, Ohio 44109, USA

Summary

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Sera from 50 mothers of G1-trisomy affected children and from 50 age-matched mothers, whose offspring included no chromosomal-aneuploidy affected children, were tested for presence of antinuclear antibody factors and nuclear staining with human squamous epithelium and with mouse liver. Consistently, more of the mothers of G1-trisomy affected children included positive findings in both tests, compared to the age-matched mothers.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 19 , Issue 4 , October 1970 , pp. 529 - 533
Copyright
Copyright © The International Society for Twin Studies 1970

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