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Alterazioni Cromosomiche dei Leucociti Indotte nel Bambino da Irradiazioni Diagnostiche — (Nota preliminare)

Published online by Cambridge University Press:  01 August 2014

L. Massimo ,
M. G. Vianello  and
F. Dagna-Bricarelli
L. Massimo
Affiliation:
Istituto di Clinica Pediatrica dell'Università di Genova
M. G. Vianello
Affiliation:
Istituto di Clinica Pediatrica dell'Università di Genova
F. Dagna-Bricarelli
Affiliation:
Istituto di Clinica Pediatrica dell'Università di Genova

Summary

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The Authors have observed a high rate of chromosomal morphologic alterations in leukocyte cultures in 10 children who had previously undergone Roentgen irradiation for diagnostic purposes. Temporary alterations have been observed, such as interruptions of chromatine on the proteic thread, defined as achromatic lesions of one or more chromatids; fragmentations of chromatids; fragments without centromere; deletions; ring-chromosomes; dicentric and tricentric chromosomes and, in certain cases, increase of polyploid mitoses, both on account of endo-reduplications or of a lacking cytoplasm division.

Riassunto

RIASSUNTO

Gli Autori hanno osservato alterazioni morfologiche dei cromosomi di culture di leucociti in elevata percentuale in 10 bambini che erano stati precedentemente sottoposti ad irradiazioni Roentgen a scopo diagnostico. Sono state riscontrate alterazioni di tipo temporaneo quali interruzioni della cromatina sul filamento proteico, definite come lesioni acromatiche di uno o di due cromatidi, frammentazioni di cromatidi, frammenti senza centromero, delezioni, cromosomi ad anello, dicentrici e tricentrici e in alcuni casi aumento delle mitosi poliploidi sia per endoreduplicazione che per mancata divisione citoplasmatica.

Résumé

RÉSUMÉ

Les Auteurs ont observé une fréquence élevée d'altérations morphologiques chromosomiales dans des cultures de leucocytes chez 10 enfants qui avaient été précédemment irradiés pour des raisons diagnostiques. Ils ont observé des altérations temporaires, telles que des interruptions du filament protéique, définies comme lésions achromatiques d'un ou deux centromères; des fragmentations de chromatides; des fragments sans centromère; des délétions; des chromosomes à anneau, dicentriques et tricentriques et, en quelques cas, une augmentation de mitoses polyploïdes soit par endoréduplication, soit par défaut de division du cytoplasme.

Zusammenfassung

ZUSAMMENFASSUNG

Verf. beobachteten an 10 Kindern, die zu diagnostischen Zwecken geröntgt worden waren, morphologische Chromosomenalterationen der Leukozytenkulturen. Es handelte sich um vorübergehende Veränderungen, wie Unterbrechung des Chromatins auf den Eiweißfasern, welche man als achromatische Läsionen einer oder zweier Chromatiden bezeichnet, Chromatidenframmentierungen, Fragmente ohne Zentromer, Delektionen, ringförmige zwei- und dreizentrige Chromosomen und in einigen Fällen Erhöhung der polyploiden Mitosen und zwar sowohl durch Endoreduplikation als durch Ausfall der Zytoplasmaspaltung.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 14 , Issue 3 , July 1965 , pp. 282 - 294
Copyright
Copyright © The International Society for Twin Studies 1965

References

Bibliografia

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