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In Vivo X-Ray Fluorescence of Bone Lead in the Study of Human Lead Metabolism: Serum Lead, Whole Blood Lead, Bone Lead, and Cumulative Exposure

Published online by Cambridge University Press:  06 March 2019

K.M. Cake ,
D.R. Chettle ,
C.E. Webber ,
C.L. Gordon ,
R.J. Bowins ,
R.H. McNutt  and
C. Vaillancourt
K.M. Cake
Affiliation:
Department of Physics and Astronomy, McMaster University, Hamilton Ontario, LSS 4M1, Canada
D.R. Chettle
Affiliation:
Department of Physics and Astronomy, McMaster University, Hamilton Ontario, LSS 4M1, Canada
C.E. Webber
Affiliation:
Department of Nuclear Medicine, Chedoke-McMaster Hospitals, Box 2000 Station A, Hamilton, Ontario, L8N 3Z5, Canada
C.L. Gordon
Affiliation:
Department of Nuclear Medicine, Chedoke-McMaster Hospitals, Box 2000 Station A, Hamilton, Ontario, L8N 3Z5, Canada
R.J. Bowins
Affiliation:
Department of Geology, McMaster University
R.H. McNutt
Affiliation:
Department of Geology, McMaster University
C. Vaillancourt
Affiliation:
Medical Adviser, Nova Pb Inc., 1200 rue Gamier, Ville-Ste-Catherine Quebec, J0L 1E0, Canada
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Extract

Traditionally, clinical studies of lead's effect on health have relied on blood lead levels to indicate lead exposure. However, this is unsatisfactory because blood lead levels have a half-life of approximately 5 weeks (Rabinowitz et al., 1976), and thus reflect recent exposure. Over 90% of the lead body burden is in bone, and it is thought to have a long residence time, thus implying that measurements of bone lead reflect cumulative exposure (Barry, 1975). So, measurements of bone lead are useful m understanding the long-term health effects of lead.

Type
VIII. In Vivo Applications of XRS
Information
Advances in X-Ray Analysis , Volume 38: Forty-third Annual Conference on Applications of X-ray Analysis , 1994 , pp. 601 - 606
Copyright
Copyright © International Centre for Diffraction Data 1994

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