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Development of L-Line X-Ray Fluorescence Instrumentation and its Applications to In-Vivo Measurement of Lead in Bone

Published online by Cambridge University Press:  06 March 2019

John E. Rosen
John E. Rosen*
Affiliation:
Albert Einstein College of Medicine, Montefiore Medical Center Bronx, New York 10467
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Extract

Initially, Wielopolski (Wielopolski et al. 1981) used x-rays from either a 125I or a 105Cd source to estimate lead (Pb) in tibial cortical bone in intact legs, post-mortem. This system utilized the Lα and Lβ x-rays of Pb with energies of 10.5 and 12.6 keV, respectively. The minimum detection limit (MDL) was considered to be comparable with existing K-line x-ray fluorescence (KXRF) instruments, namely, 20-30 ppm. The feasibility of partially polarized radiation (Barkla, 1906) was assessed from a 125I source on Pb (No3)2 (10,000 ppm) dissolved in wa:er. Reduction of the detector total count rate was observed by a factor of two; and reduction in background by the same factor was appaent. This preliminary study suggested that, with improved design, tlie MDL might be lowered by a factor of five (Wielopolski et al., 1981).

Type
VIII. In Vivo Applications of XRS
Information
Advances in X-Ray Analysis , Volume 38: Forty-third Annual Conference on Applications of X-ray Analysis , 1994 , pp. 573 - 577
Copyright
Copyright © International Centre for Diffraction Data 1994

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