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Optimal sampling for pedigree analysis: tracing a single gene

Published online by Cambridge University Press:  01 July 2016

E. A. Thompson*
Affiliation:
University of Cambridge
*
Postal address: Statistical Laboratory, 16 Mill Lane, Cambridge, CB2 1SB, U.K.

Abstract

In fitting genetic models on the basis of observations on an interrelated structure, sequential procedures can enhance efficiency. In this paper we consider the case of a rare gene segregating in a single large pedigree. The sampling rule is dictated by the effect of observations on the genotypic probability distribution of unobserved relatives; this effect is investigated.

Type
Research Article
Copyright
Copyright © Applied Probability Trust 1982 

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References

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