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Measuring interference in the chiasma renewal formation process

Published online by Cambridge University Press:  01 July 2016

Samuel Karlin*
Affiliation:
Stanford University
Uri Liberman*
Affiliation:
Tel-Aviv University
*
Postal address: Department of Mathematics, Stanford University, Stanford, CA 94305, U.S.A.
∗∗Postal address: Department of Statistics, Tel-Aviv University, Ramat Aviv, Tel-Aviv, Israel.

Abstract

Multilocus recombination structure is introduced using recombination and linkage values. The notion of chiasma interference is discussed and the coincidence measure of interference is defined. The global nature of positive, negative or non-interference is characterized using linkage values. In the case of the renewal chiasma formation process with interdistance distribution F it is shown that the nature of interference depends on the ‘ageing' properties of F such as IFR, NBU, NBUE and DMRL.

Type
Research Article
Copyright
Copyright © Applied Probability Trust 1983 

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Footnotes

Research supported in part by NSF Grant MCS79-24310 and NIH Grants GM10452-18 and GM28016.

References

Bailey, N. T. J. (1961) Introduction to the Mathematical Theory of Genetic Linkage. Clarendon Press, Oxford.Google Scholar
Barlow, R. E. and Proschan, F. (1975) Statistical Theory of Reliability and Life Testing: Probability Models. Holt, Rinehart and Winston, New York.Google Scholar
Brown, M. (1981) Further monotonicity properties for specialized renewal processes. Ann. Prob. 9, 891895.Google Scholar
Fisher, R. A., Lyon, M. F. and Owen, A. R. G. (1947) The sex chromosome in the house mouse. Heredity 1, 355365.Google Scholar
Haldane, J. B. S. (1919) The combination of linkage values, and the calculation of distance between the loci of linked factors. J. Genet. 8, 299309.Google Scholar
Jennings, H. S. (1923) The numerical relations in the crossing over of the genes with a critical examination of the theory that the genes are arranged in a linear series. Genetics 8, 393457.CrossRefGoogle Scholar
Karlin, S. and Taylor, H. M. (1975) A First Course in Stochastic Processes, Academic Press, New York.Google Scholar
Mather, K. (1936) The determination of position in crossing over. J. Genet. 33, 207235.Google Scholar
Mather, K. (1937) The determination of position in crossing over. II. The chromosome length-chiasma frequency relation. Cytologia Jub. Vol., 514526.Google Scholar
Owen, A. R. G. (1950) The theory of genetical recombination. Adv. Genet. 3, 127157.Google ScholarPubMed
White, R. L. and Fox, M. S. (1974) On the molecular basis of high negative interference. Proc. Nat. Acad. Sci. USA 71, 15441548.Google Scholar