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DNA fragment mass distributions following molecular recombination

Published online by Cambridge University Press:  01 July 2016

Thomas A. Darden  and
Michael A. Resnick
Thomas A. Darden*
Affiliation:
National Institute of Environmental Health Sciences
Michael A. Resnick*
Affiliation:
National Institute of Environmental Health Sciences
*
∗Postal address: Biometry and Risk Assessment Program, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
∗∗Postal address: Toxicology Research and Testing Program, NIEHS, P.O. Box 12233, Research Triangle Park, NC 27709, USA.
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Abstract

A mathematical model for the process of recombinational repair of DNA damage is presented. Based on the model, a method is proposed for analyzing fragment mass distributions from experiments designed to detect recombinational repair in cells. The procedures developed can be used to analyze experiments involving sucrose-gradient measurements of mass distributions. The model also provides a framework for discussion of various molecular models of this repair process.

Keywords

DNA DAMAGE
Type
Research Article
Information
Advances in Applied Probability , Volume 17 , Issue 3 , September 1985 , pp. 496 - 513
Copyright
Copyright © Applied Probability Trust 1985 

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