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Selection for milk fat and milk protein composition

Published online by Cambridge University Press:  30 July 2013

H. Bovenhuis*
Affiliation:
Animal Breeding and Genomics Centre, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
M. H. P. W. Visker
Affiliation:
Animal Breeding and Genomics Centre, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
A. Lundén
Affiliation:
Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics, PO Box 7023, SE-75007 Uppsala, Sweden
*
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Abstract

The suitability of milk for specific dairy products might be improved by changing milk fat or milk protein composition. In the RobustMilk project, we showed that milk fat composition is determined by genetic factors. In addition, recent studies indicate that milk protein composition is strongly affected by genetic factors. This suggests that there are opportunities to change milk composition by means of selective breeding. Traditional selection is based on large-scale phenotyping and not all analytical methods are suited for this purpose. The RobustMilk project team has shown that several fatty acids can be predicted on the basis of IR spectra. Accuracy of predicting individual milk proteins based on IR spectra is low. In addition to phenotypic records, selection might be based on genotypic information. DGAT1 and SCD1 genotypes are strongly associated with fat composition. β-Lactoglobulin, β-casein and κ-casein protein variants are strongly associated with protein composition. We conclude that tools are now available for changing detailed milk fat or milk protein composition by means of selective breeding.

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Full Paper
Copyright
Copyright © The Animal Consortium 2013 

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References

Aschaffenburg, R, Drewry, J 1955. Occurrence of different beta-lactoglobulins in cow's milk. Nature 30, 218219.Google Scholar
Bastin, C, Gengler, N, Soyeurt, H 2011. Phenotypic and genetic variability of production traits and milk fatty acid contents across days in milk for Walloon Holstein first-parity cows. Journal of Dairy Science 94, 41524163.Google Scholar
Bauman, DE, Griinari, JM 2003. Nutritional regulation of milk fat synthesis. Annual Review of Nutrition 23, 203227.Google Scholar
Bernard, L, Leroux, C, Hayes, H, Gautier, M, Chilliard, Y, Martin, P 2001. Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3′-UTR sequence arising from a single exon. Gene 281, 5361.Google Scholar
Bersaglieri, T, Sabeti, PC, Patterson, N, Vanderploeg, T, Schaffner, SF, Drake, JA, Rhodes, M, Reich, DE, Hirschhorn, JN 2004. Genetic signatures of strong recent positive selection at the lactase gene. American Journal of Human Genetics 74, 11111120.CrossRefGoogle ScholarPubMed
Bonfatti, V, Di Martino, G, Cecchinato, A, Degano, L, Carnier, P 2010. Effects of β-κ-casein (CSN2-CSN3) haplotypes, β-lactoglobulin (BLG) genotypes, and detailed protein composition on coagulation properties of individual milk of Simmental cows. Journal of Dairy Science 93, 38093817.Google Scholar
Bonfatti, V, Cecchinato, A, Gallo, L, Blasco, A, Carnier, P 2011. Genetic analysis of detailed milk protein composition and coagulation properties in Simmental cattle. Journal of Dairy Science 94, 51835193.Google Scholar
Bouwman, AC, Bovenhuis, H, Visker, MHPW, van Arendonk, JAM 2011. Genome-wide association of milk fatty 1 acids in Dutch dairy cattle. BMC Genetics 12, 43.Google Scholar
Bouwman, AC, Visker, MHPW, van Arendonk, JAM, Bovenhuis, H 2012. Genomic regions associated with bovine milk fatty acids in both summer and winter milk samples. BMC Genetics 13, 9.Google Scholar
Chilliard, Y, Ferlay, A, Doreau, M 2001. Effect of different types of forages, animal fat or marine oils in cow's diet on milk fat secretion and composition, especially conjugated linoleic acid (CLA) and polyunsaturated fatty acids. Livestock Production Science 70, 3148.Google Scholar
Comin, A, Cassandro, M, Chessa, S, Ojala, M, Dal Zotto, R, De Marchi, M, Carnier, P, Gallo, L, Pagnacco, G, Bittante, G 2008. Effects of composite β- and κ-casein genotypes on milk coagulation, quality, and yield traits in Italian Holstein cows. Journal of Dairy Science 91, 40224027.CrossRefGoogle ScholarPubMed
Craninx, M, Steen, A, Van Laar, H, Van Nespen, T, Martin-Tereso, J, De Baets, B, Fievez, V 2008. Effect of lactation stage on the odd- and branched-chain milk fatty acids of dairy cattle under grazing and indoor conditions. Journal of Dairy Science 91, 26622677.Google Scholar
EFSA 2009. Scientific Report of EFSA prepared by a DATEX Working Group on the potential health impact of β-casomorphins and related peptides. EFSA Scientific Report 231, pp. 1–107.Google Scholar
Elliott, RB, Harris, DP, Hill, JP, Bibby, NJ, Wasmuth, HE 1999. Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consumption. Diabetologia 42, 292296.Google Scholar
Elofsson, UM, Paulsson, MA, Sellers, P, Arnebrant, T 1996. Adsorption during heat treatment related to the thermal unfolding/aggregation of β-lactoglobulins A and B. Journal of Colloid and Interface Science 183, 408415.Google Scholar
Feagan, JT 1979. Factors affecting protein composition of milk and their significance to dairy processing. Australian Journal of Dairy Technology 34, 7781.Google Scholar
Garnsworthy, PC, Feng, S, Lock, AL, Royal, MD 2010. Short communication: heritability of milk fatty acid composition and stearoyl-CoA desaturase indices in dairy cows. Journal of Dairy Science 93, 17431748.Google Scholar
German, JB, Dillard, CJ, Ward, RE 2002. Bioactive components in milk. Current Opinion in Clinical Nutrition and Metabolic Care 5, 653658.Google Scholar
Grisart, B, Coppieters, W, Farnir, F, Karim, L, Ford, C, Berzi, P, Cambisano, N, Mni, M, Reid, S, Simon, P, Spelman, R, Georges, M, Snell, R 2002. Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Research 12, 222231.Google Scholar
Hallén, E, Wedholm, A, Andrén, A, Lundén, A 2008. Effect of β-casein, κ-casein and β-lactoglobulin genotypes on concentration of milk protein variants. Journal of Animal Breeding and Genetics 125, 119129.Google Scholar
Heck, JML, Schennink, A, van Valenberg, HJF, Bovenhuis, H, van Arendonk, JAM, van Hooijdonk, ACM 2009. Effects of milk protein variants on the protein composition of bovine milk. J Dairy Sci 92, 11921202.Google Scholar
Jabed, A, Wagner, S, McCracken, J, Wells, DN, Laible, G 2012. Targeted microRNA expression in dairy cattle directs production of β-lactoglobulin-free, high-casein milk. PNAS 109, 1681116816.Google Scholar
Jensen, RG 2002. The composition of bovine milk lipids: January 1995 to December 2000. Journal of Dairy Science 85, 295350.Google Scholar
Lundén, A, Nilsson, M, Janson, L 1997. Marked effect of β-lactoglobulin polymorphism on the ratio of casein to total protein in milk. Journal of Dairy Science 80, 29963005.Google Scholar
MacGibbon, AKH, Taylor, MW 2006. Composition and structure of bovine milk lipids. In Advanced dairy chemistry: lipids, Vol. 2. (ed. PF Fox, PLH McSweeney), pp. 142. Springer, New York.Google Scholar
Maurice-Van Eijndhoven, MHT, Hiemstra, SJ, Calus, MPL 2011. Short communication: milk fat composition of 4 cattle breeds in the Netherlands. Journal of Dairy Science 94, 10211025.Google Scholar
Maurice-Van Eijndhoven, MHT, Soyeurt, H, Dehareng, F, Calus, MPL 2013. Validation of fatty acid predictions in milk using mid-infrared spectrometry across cattle breeds. Animal 7, 348354.Google Scholar
McClenaghan, M, Springbett, A, Wallace, RM, Wilde, CJ, Clark, AJ 1995. Secretory proteins compete for production in the mammary-gland of transgenic mice. Biochemical Journal 310, 637641.Google Scholar
Mele, M, Dal Zotto, R, Cassandro, M, Conte, G, Serra, A, Buccioni, A, Bittante, G, Secchiari, P 2009. Genetic parameters for conjugated linoleic acid, selected milk fatty acids, and milk fatty acid unsaturation of Italian Holstein–Friesian cows. Journal of Dairy Science 92, 392400.Google Scholar
Mele, M, Conte, G, Castiglioni, B, Chessa, S, Macciotta, NP, Serra, A, Buccioni, A, Pagnacco, G, Secchiari, P 2007. Stearoyl-coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins. Journal of Dairy Science 90, 44584465.Google Scholar
Mensink, RP, Zock, PL, Kester, ADM, Katan, MB 2003. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. American Journal of Clinical Nutrition 77, 11461155.Google Scholar
Miglior, F, Muir, BL, Van Doormaal, BJ 2005. Selection indices in Holstein cattle of various countries. Journal of Dairy Science 88, 12551263.Google Scholar
Moioli, B, Contarini, G, Avalli, A, Catillo, G, Orru, L, De Matteis, G, Masoero, G, Napolitano, F 2007. Short communication: effect of stearoyl-coenzyme A desaturase polymorphism on fatty acid composition of milk. Journal of Dairy Science 90, 35533558.Google Scholar
Ng-Kwai-Hang, KF, Kim, S 1996. Different amounts of β-lactoglobulin A and B in milk from heterozygous AB cows. International Dairy Journal 6, 689695.Google Scholar
Palmquist, DL 2006. Milk fat: origin of fatty acids and influence of nutritional factors thereon. In Advanced dairy chemistry: lipids, Vol. 2. (ed. PF Fox, PLH McSweeney), pp. 4392. Springer, New York.Google Scholar
Peterson, DG, Kelsey, JA, Bauman, DE 2002. Analysis of variation in cis-9, trans-11 conjugated linoleic acid (CLA) in milk fat of dairy cows. Journal of Dairy Science 85, 21642172.Google Scholar
Rutten, MJM, Heck, JML, Bovenhuis, H, van Arendonk, JAM 2011. Predicting bovine milk protein composition based on milk FTIR spectra. Journal of Dairy Science 94, 56835690.Google Scholar
Rutten, MJM, Bovenhuis, H, Hettinga, KA, van Valenberg, HJF, van Arendonk, JAM 2009. Predicting bovine milk fat composition using infrared spectrometry based on milk samples collected in Winter and Summer. Journal of Dairy Science 92, 62026209.Google Scholar
Schennink, A, Heck, JML, Bovenhuis, H, Visker, MHPW, Van Valenberg, HJF, Van Arendonk, JAM 2008. Milk fatty acid unsaturation: genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: diacylglycerol acyltransferase (DGAT1). Journal of Dairy Science 91, 21352143.Google Scholar
Schennink, A, Stoop, WM, Visker, MHPW, Heck, JML, Bovenhuis, H, van der Poel, JJ, van Valenberg, HJF, van Arendonk, JAM 2007. DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Animal Genetics 38, 467473.Google Scholar
Schopen, GCB, Heck, JML, Bovenhuis, H, Visker, MHPW, van Valenberg, HJF, van Arendonk, JAM 2009. Genetic parameters for major milk proteins in Dutch Holstein–Friesians. Journal of Dairy Science 92, 11821191.Google Scholar
Schopen, GCB, Visker, MHPW, Koks, PD, Mullaart, E, van Arendonk, JAM, Bovenhuis, H 2011. Whole genome association study for milk protein composition in dairy cattle. Journal of Dairy Science 94, 31483158.Google Scholar
Stoop, WM, Bovenhuis, H, Heck, JML, van Arendonk, JAM 2009. Effect of lactation stage and energy status on milk fat composition of Holstein–Friesian cows. Journal of Dairy Science 92, 14691478.Google Scholar
Stoop, WM, van Arendonk, JAM, Heck, JML, van Valenberg, HJF, Bovenhuis, H 2008. Genetic parameters for milk fatty acids and milk production traits of Dutch Holstein Friesians. Journal of Dairy Science 91, 385394.Google Scholar
Soyeurt, H, Dardenne, P, Dehareng, F, Bastin, C, Gengler, N 2008. Genetic parameters of saturated and monounsaturated fatty acid content and the ratio of saturated to unsaturated fatty acids in bovine milk. Journal of Dairy Science 91, 36113626.Google Scholar
Soyeurt, H, Dardenne, P, Gillon, A, Croquet, C, Vanderick, S, Mayeres, P, Bertozzi, C, Gengler, N 2006a. Variation in fatty acid contents of milk and milk fat within and across breeds. Journal of Dairy Science 89, 48584865.Google Scholar
Soyeurt, H, Dehareng, F, Gengler, N, McParland, S, Wall, E, Berry, DP, Coffey, M, Dardenne, P 2011. Mid-infrared prediction of bovine milk fatty acids across multiple breeds, production systems and countries. J Dairy Sci 94, 16571667.Google Scholar
Soyeurt, H, Dardenne, P, Dehareng, F, Lognay, G, Veselko, D, Marlier, M, Bertozzi, C, Mayeres, P, Gengler, N 2006b. Estimating fatty acid content in cow milk using mid-infrared spectrometry. Journal of Dairy Science 89, 36903695.Google Scholar
Thaller, G, Kramer, W, Winter, A, Kaupe, B, Erhardt, G, Fries, R 2003. Effects of DGAT1 variants on milk production traits in German cattle breeds. Journal of Animal Science 81, 19111918.Google Scholar
Vallas, M, Kaart, T, Varv, S, Parna, K, Joudu, I, Viinalass, H, Parna, E 2012. Composite beta-kappa-casein genotypes and their effect on composition and coagulation of milk from Estonian Holstein cows. Journal of Dairy Science 95, 67606769.Google Scholar
Van den Berg, G, Escher, JTM, de Koning, PJ, Bovenhuis, H 1992. Genetic polymorphism of kappa-casein and beta-lactoglobulin in relation to milk composition and processing properties. Netherlands Milk and Dairy Journal 46, 145168.Google Scholar
Vlaeminck, B, Fievez, V, Cabrita, ARJ, Fonseca, AJM, Dewhurst, RJ 2006a. Factors affecting odd- and branched-chain fatty acids in milk: a review. Animal Feed Science and Technology 131, 389417.Google Scholar
Vlaeminck, B, Fievez, V, Tamminga, S, Dewhurst, RJ, van Vuuren, A, De Brabander, D, Demeyer, D 2006b. Milk odd- and branched-chain fatty acids in relation to the rumen fermentation pattern. Journal of Dairy Science 89, 39543964.Google Scholar
Visker, MHPW, Dibbits, BW, Kinders, SM, Van Valenberg, HJF, Van Arendonk, JAM, Bovenhuis, H 2011. Association of bovine β-casein protein variant I with milk production and milk protein composition. Animal Genetics 42, 212218.Google Scholar
Walstra, P, Jennes, R 1984. Dairy chemistry and physics. John Wiley, New York.Google Scholar
Wedholm, A, Larsen, LB, Lindmark-Månsson, H, Karlsson, AH, Andrén, A 2006. Effect of protein composition on the cheese-making properties of milk from individual dairy cows. Journal of Dairy Science 89, 23963305.Google Scholar
Winter, A, Kramer, W, Werner, FA, Kollers, S, Kata, S, Durstewitz, G, Buitkamp, J, Womack, JE, Thaller, G, Fries, R 2002. Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Proceedings of the National Academy of Sciences of the United States of America 99, 93009305.CrossRefGoogle Scholar
Wit De, JN 1998. Nutritional and functional characteristics of whey proteins and food products. Journal of Dairy Science 81, 597608.Google Scholar