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Structural brain network differences in bipolar disorder using with similarity-based approach

Published online by Cambridge University Press:  22 December 2020

Miho Ota Open the ORCID record for Miho Ota [Opens in a new window] ,
Takamasa Noda ,
Noriko Sato ,
Shinsuke Hidese ,
Toshiya Teraishi ,
Hiroshi Matsuda  and
Hiroshi Kunugi
Miho Ota*
Affiliation:
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo187-8502, Japan
Takamasa Noda
Affiliation:
Department of Psychiatry, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo187-8502, Japan
Noriko Sato
Affiliation:
Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo187-8502, Japan
Shinsuke Hidese
Affiliation:
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo187-8502, Japan
Toshiya Teraishi
Affiliation:
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo187-8502, Japan
Hiroshi Matsuda
Affiliation:
Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo187-8502, Japan
Hiroshi Kunugi
Affiliation:
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo187-8502, Japan
*
Author for correspondence: Miho Ota, Email: [email protected]
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Abstract

Objective: Previous studies have shown differences in the regional brain structure and function between patients with bipolar disorder (BD) and healthy subjects, but little is known about the structural connectivity between BD patients and healthy subjects. In this study, we evaluated the disease-related changes in regional structural connectivity derived from gray matter magnetic resonance imaging (MRI) scans. Methods: The subjects were 73 patients with BD and 80 healthy volunteers who underwent 3-Tesla MRI. Network metrics, such as the small world properties, were computed. We also performed rendering of the network metric images such as the degree, betweenness centrality, and clustering coefficient, on individual brain image. Then, we estimated the differences between them, and evaluate the relationships between the clinical symptoms and the network metrics in the patients with BD. Results: BD patients showed a lower clustering coefficient in the right parietal region and left occipital region, compared with healthy subjects. A weak negative correlation between Young mania rating scale and clustering coefficient was found in left anterior cingulate cortex. Conclusions: We found differences in gray matter structural connectivity between BD patients and healthy subjects by a similarity-based approach. These points may provide objective biological information as an adjunct to the clinical diagnosis of BD.

Keywords

bipolar disorderclustering coefficientdegreesmall world propertystructural brain network
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 33 , Issue 3 , June 2021 , pp. 121 - 125
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Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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