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Skin conductance and schizophrenic symptomatology

Published online by Cambridge University Press:  18 September 2015

J. à Campo ,
H.L.G.J. Merckelbach ,
H. Nijman ,
M. Yeates-Frederikx  and
W. Allertz
J. à Campo
Affiliation:
Psychiatrisch Centrum Weiterhof te Heerlen.
H.L.G.J. Merckelbach
Affiliation:
Faculteit Psychologie van de Universiteit Maastricht.
H. Nijman
Affiliation:
Psychiatrisch Centrum Weiterhof te Heerlen. Faculteit Psychologie van de Universiteit Maastricht.
M. Yeates-Frederikx
Affiliation:
Psychiatrisch Centrum Weiterhof te Heerlen.
W. Allertz
Affiliation:
Psychiatrisch Centrum Weiterhof te Heerlen.
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Summary

Skin conductance is a psychophysiological parameter that reflects fundamental processes such as attention and arousal. The present study explored whether deviations in skin conductance activity are associated with severity of schizophrenic symptoms. For this purpose, Skin Conductance Responses (SCRs) to discrete stimuli (80 dB noises) and Skin Conductance Levels (SCLs) of 37 schizophrenic patients and 31 healthy volunteers were recorded. In accordance with previous studies, schizophrenic patients were found to be hyporesponsive compared to healthy controls. More specifically, almost half of the patients (46%) did not react with any SCR to the first 3 stimuli, whereas only 10% of the control group exhibited such a non-responding. Accordingly, the mean amplitude of the first 3 SCRs – as measured in u Siemens – was found to be significantly lower in patients compared to controls. As well, mean SCL was found to be (marginally) elevated in the patient group. This was especially the case for patients who did exhibit SCRs. In the patient group, a negative correlation was found between amplitude of SCRs and symptom severity. This association was mainly carried by a significant correlation between positive symptoms and reduced SCRs. The clinical relevance of these findings is discussed in detail.

Keywords

skin conductanceschizophreniaSCRSCL
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 4 , December 2000 , pp. 177 - 182
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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References

Literatuur

1.Merekelbach, HLGJ. Nijman, HLI. Ravclli, DP. Kcncmans, L. Schizofrenie en huidgclciding: ecn litcratuuroverzicht. Tijdschr Psvchiatr 1995:37:475–487.Google Scholar
2.Öhman, A. The orienting response, attention, and learning: An information processing perspective. In: Kimmel, HD, van Olst, EH, Orlebeke, JF (eds.) The Orienting Reflex in Humans. Hillsdale. Erlbaum. 1979.Google Scholar
3.Szymanski, S. Kane, J. Lieberman, J. Trait markers in schizophrenia. Are they diagnostic? In: DSM-IV Sourcebook. Volume I. Wastingthon DC, American Psychiatric Association. 1994.Google Scholar
4.Bosch, RJ van den. Attentional Correlates of Schizophrenia and Related Disorders. Academisch proefschrilt; Maastricht, Rijksuniversiteit. 1982.Google Scholar
5.Braff, DL. Information processing and attention dysfunctions in schizophrenia. Schizophr Hull 1993:19:233–259.CrossRefGoogle ScholarPubMed
6.Ricksher, C. Jung, CG. Further investigations on the galvanic phenomenon and respiration in normal and insane individuals. J Abnorm Psychol 1997:2:189–217.CrossRefGoogle Scholar
7.Boucsein, W. Elektrodermale Aktivität: Grundlagen. Methoden und Anwendungen. Berlin. Springer, 1988.CrossRefGoogle Scholar
8.Lim, CL. Gordon, E. Harris, A. Bahramali, H, Li, WM. Manor, B, Rennie, C. Electrodermal activity in schizophrenia: A quantative study using a short interstimulus paradim. Biol Psychiatry 1999:45:127–135/CrossRefGoogle Scholar
9.Öhman, A, Hultman, CM. Electrodermal activity and obstetric complications in schizophrenia. J Abnorm Psychol 1998:107:228–237.CrossRefGoogle ScholarPubMed
10.Perry, W, Felger, T, Braff, D. The relationship between skin conductance hyporesponsivity and perseverations in schizophrenia patients. Biol Psychiatry 1998:44:459–465.CrossRefGoogle ScholarPubMed
11.Hazlett, EA. Dawson, ME. Filion, DL. Schell, AM, Nuechterlein, KH. Autonomic orienting and the allocation of processing resources in schizophrenia patients and putatively at-risk individuals. J Abnorm Psychol 1997:106:171–181.CrossRefGoogle ScholarPubMed
12.Zahn, TP. Jacobsen, LK. Gordon, CT, Mckenna, K. Frazier, JA. Rapoport, JL. Autonomic nervous system markers of psychopathology in childhood-onset schizophrenia. Arch Gen Psychiatry 1997:54:904–912.CrossRefGoogle ScholarPubMed
13.Schnur, DB, Bernstein, AS. Yeagcr, A. Smith, S. Bernstein, P. The relationship of the skin conductance and finger pulse amplitude components of the orienting response to season of birth in schizophrenia and depression. Biol Psychiatry 1995:37:34–41.CrossRefGoogle ScholarPubMed
14.Bernstein, AS. Frith, CD. Gruzelier, JH. Patterson, T. Straube, E. Venables, PH. Zahn, TP. An analysis of the skin conductance orienting response in samples of American. British, and German schizophrenics. Biol Psychol 1982:14:155–211.CrossRefGoogle ScholarPubMed
15.Simons, RF, Losito, BD. Rose, SC. MacMillan, FW. Electrodermal nonrcsponding among college undergraduates: Temporal stability, situational specificity, and relationship to heart rate change. Psychophysiol 1983:20:498–505.CrossRefGoogle ScholarPubMed
16.Iacono, WG, Lykken, DT. Peloquin, LJ, Lumry, AE. Valentine, RH, Tuason, V. Electrodermal activity in euthymic patients with affective disorders: A possible marker for depression. Arch Gen Psychiatry 1983:40:557–565.CrossRefGoogle ScholarPubMed
17.Gruzelier, JH. Clinical attributes of schizophrenic skin conductance responders and non-responders. Psychol Med 1976:6:246–249.CrossRefGoogle ScholarPubMed
18.Straube, ER. On the meaning of electrodermal non-responding in schizophrenia. J Nerv Ment Dis 1979:167:601–611.CrossRefGoogle Scholar
19.Dawson, ME. Nuechtcrlein, KH. Schell, A. Mintz, J. Concurrent and predictive electrodermal correlates of symptomatology in recent-onset schizophrenic patients. J Abnorm Psychol 1992:101:153–164.CrossRefGoogle ScholarPubMed
20.Öhman, A, Nordby, H. d'Elia, G. Orienting in schizophrenia: Habituation to auditory stimuli of constant and varying intensity in patients high and low in skin conductance responsivity. Psychophysiol 1989:26:48–61.CrossRefGoogle ScholarPubMed
21.Bernstein, AS. Orienting response research in schizophrenia: where we have come and where we might go. Schizophr Bull 1987:13:623–641.CrossRefGoogle ScholarPubMed
22.Fuentes, I. Merita, MG, Miquel, M. Rojo, J. Relationships between electrodermal activity and symptomatology in schizophrenia. Psychopathol 1993:26:47–82.CrossRefGoogle ScholarPubMed
23.Green, MRNuechtcrlein, KH, Satz, P. The relationship of symptomatology and medication to electrodermal activity in schizophrenia. Psychophysiol 1989:26:148–157.CrossRefGoogle ScholarPubMed
24.Schneider, SJ. Electrodermal activity and therapeutic response to neuroleptic treatment in chronic schizophrenic in-patients. Psychol Med 1982:12:607–613.CrossRefGoogle ScholarPubMed
25.Lindström, EM. Öhlund, LS. Lindström, LH. Öhman, A. Symptomatology and electrodermal activity as predictors of neuroleptic response in young male schizophrenic inpatients. Psychiatr Res 1992:42:145–158.CrossRefGoogle ScholarPubMed
26.Dawson, ME. Psychophysiology at the interface of clinical science, cognitive science, and neuroscience. Psychophysiol 1990:27:243–255.CrossRefGoogle ScholarPubMed
27.Dawson, ME. Nuechtcrlein, KU. Schell, A. Electrodermal anomalies in recent-onset schizophrenia: relationships to symptoms and prognosis. Schizophr Bull 1992:18:295–311.CrossRefGoogle ScholarPubMed
28.Kay, SR. Opler, LA. Fiszbein, A. Positive and Negative Syndrome Scale (PANSS) Rating Manual. New York, Department of Psychiatry. Albert Einstein College of Medicine. Montefiore Medical Center, and Schizophrenia Research Unit. Bronx Psychiatric Center. 1986Google Scholar
29.Öhman, A. Electrodermal activity and vulnerability to schizophrenia: A review. Biol Psychol 1981:12:87–145.CrossRefGoogle ScholarPubMed
30.Spohn, HE. Coyne, L, Wilson, JK. Hayes, K. Skin conductance orienting response in chronic schizophrenics: the role of neuroleptics. J Abnorm Psychol 1989:98:478–486.CrossRefGoogle ScholarPubMed
31.Wang, GH. Neural Control of Sweating. Madison. University of Winsconsin Press. 1964.Google Scholar
32.Cannon, TD. Fuhrmann, M. Mednick, SA. Machon, RA. Parnas, J. Schulsinger, F. Third ventricle enlargement and reduced electrodermal responsiveness. Psychophysiol 1988:25:153–156.CrossRefGoogle ScholarPubMed
33.Bosch, RJ van den. Schizofrenie: Subjectieve Ervaringen en Cognitief Onderzoek. Houten, Bohn. Stafleu & van Loghum. 1993.Google Scholar
34.Iacono, WG. Ficken, JW. Research strategies employing psychophysiological measures: Identifying and using psychophysiological markers. In: Turpin, G (ed.). Handbook of Clinical Psychophysiology. New York. Wiley. 1989.Google Scholar
35.Bosch, RJ van den. Psychofysiologische aspecten van schizofrenie. In: van den Bosch, RJ. van Meer, CR. Dingemans, PMAJ. Linszcn, DH. Schizofrenie: Recente Ontwikkelingen in Onderzoek en Behandeling. Deventer, van Loghum Slaterus. 1988.Google Scholar
36.Praag, H van. Diagnostiek en behandeling. De psycholoog 1991:26:515–519.Google Scholar
37.Straube, ER. Schied, HW, Rein, W. Breycr-Pfaff, U. Autonomie nervous system differences as predictors of short-term outcome in schizophrenics. Pharmacopsychiatry 1987:20:105–110.CrossRefGoogle Scholar
38.Csemansky, JG. Problems in the classification of schizophrenics as neuroleptic responders and nonresponders. J Nerv Ment Dis 1985:173:325–331.CrossRefGoogle Scholar