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A review of EEG and ERP studies in bipolar disorder

Published online by Cambridge University Press:  24 June 2014

Racheal Degabriele  and
Jim Lagopoulos
Racheal Degabriele
Affiliation:
Discipline of Psychological Medicine, University of Sydney, Sydney, NSW, Australia CADE Clinic, Royal North Shore Hospital, Sydney, NSW, Australia
Jim Lagopoulos*
Affiliation:
Discipline of Psychological Medicine, University of Sydney, Sydney, NSW, Australia CADE Clinic, Royal North Shore Hospital, Sydney, NSW, Australia Advanced Research and Clinical High-field Imaging (ARCHI), Northern Clinical School, University of Sydney, Sydney, NSW, Australia
*
Associate Professor Jim Lagopoulos, Department of Psychological Medicine, Level 5, Building 36, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. Tel: +61 2 99267746; Fax: +61 2 99267730; E-mail: [email protected]
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Abstract

Objective:

The electroencephalogram (EEG) can be a useful tool in determining differences in general neural activity and specific waveforms in individuals with a number of psychiatric disorders. This paper aims to outline and discuss significant findings in EEG and event-related potential (ERP) research into bipolar disorder (BD).

Methods:

A literature review was performed through searches of MedLine, EMBASE, CINAHL and PsycInfo medical research databases for papers published from 1985 onwards. References of selected articles were also examined for other relevant studies.

Results:

Differences in general EEG data were found in subjects with BD, namely increased theta and delta and decreased alpha wave bands. Changes in EEG were also found in euthymic BD subjects and those undergoing medication programmes. ERP studies commonly report prolonged latencies and reduced amplitudes in the P300 component. Hyperfunctioning of the right hemisphere in BD was also reported in some studies, although further confirmation of this finding is required. Finally, the effects of medication and the role that genetics plays in EEG still remain unclear.

Conclusions:

The literature reviewed demonstrates supporting evidence for the presence of significant differences in EEG and ERP data in subjects with BD. However, methodological considerations such as varying mood states and medication status of the patients need to be followed more stringently for future research to bring about a robust model of the cognitive deficits of BD.

Keywords

bipolar disorderEEGelectrophysiologyERPP300
Type
Review article
Information
Acta Neuropsychiatrica , Volume 21 , Issue 2 , April 2009 , pp. 58 - 66
Copyright
Copyright © 2009 Blackwell Munksgaard

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