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Putting the brain in Jeopardy: a novel comprehensive and expressive language task?

Published online by Cambridge University Press:  24 June 2014

Erik Magnus Berntsen ,
Inge-Andre Rasmussen ,
Petter Samuelsen ,
Jian Xu ,
Olav Haraldseth ,
Jim Lagopoulos  and
Gin S. Malhi
Erik Magnus Berntsen
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Inge-Andre Rasmussen
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Petter Samuelsen
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Jian Xu
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Olav Haraldseth
Affiliation:
Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Jim Lagopoulos
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia Mayne Clinical Research Imaging Center, Sydney, Australia Neuroscience Research Group, Mood Disorders Unit, Black Dog Institute, Prince of Wales Hospital, Sydney, Australia
Gin S. Malhi*
Affiliation:
School of Psychiatry, University of New South Wales, Sydney, Australia Mayne Clinical Research Imaging Center, Sydney, Australia Neuroscience Research Group, Mood Disorders Unit, Black Dog Institute, Prince of Wales Hospital, Sydney, Australia
*
Dr Gin S. Malhi, Neuroscience Research Group, Mayne Clinical Research Imaging Center, Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia. Tel: +61 2 9382 3719; Fax: +61 2 9382 8208; E-mail: [email protected]
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Abstract

Objective:

To develop and test a novel fMRI compatible comprehensive and expressive language task that reliably and predictably activates both Wernicke's and Broca's cortical brain regions, respectively, and has utility for the determination of hemispheric language dominance.

Methods:

Ten healthy men (seven) and women (three) were administered a task based on the television game Jeopardy that was adapted for fMRI presentation. The task was programmed using E-PRIME software and designed to run as an event-related experiment. The study was conducted on 3 T MRI Phillips Intera scanner, and data was anlysed using Brain Voyager QX. All subjects provided written informed consent.

Results:

The Jeopardy task produced robust left hemisphere activation in regions corresponding to Wernicke's and Broca's areas.

Conclusion:

This novel fMRI compatible task (Jeopardy) reliably maps both Broca's and Wernicke's areas with robust hemispheric lateralization. It is potentially useful in language localization studies as it offers advantages over conventional procedures and other fMRI tasks by virtue of being non-invasive and mapping both language areas in one experiment.

Keywords

fMRIlanguage processingneurosurgical planningWernickeBroca
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 18 , Issue 2 , April 2006 , pp. 115 - 119
Copyright
Copyright © 2006 Blackwell Munksgaard

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References

Broca, P. Nouvelle observation d'aphemie par une lesion de la moitie posterieure deuxieme et troisieme circonvolution frontales gauches. Bull Soc Anat 1861;36: 398–407. Google Scholar
Broca, P. Localizations des functions cerebrales: siege de la faculte du language articule. Bull Soc Anthropol 1863;4: 200–208. Google Scholar
Wernicke, C. Der aphasische symptomenkomplex: eine psychologische studie auf anatomischer basis. Breslau: Max Cohn and Wegert, 1997. Google Scholar
Wada, JA. Clinical experimental observations of carotid artery injections of sodium amytal. Brain Cogn 1874;33: 11–13. CrossRefGoogle ScholarPubMed
Lurito, JT, Lowe, MJ, Sartorius, C, Mathews, VP. Comparison of fMRI and intraoperative direct cortical stimulation in localization of receptive language areas. J Comput Assist Tomogr 2000;24: 99–105. CrossRefGoogle ScholarPubMed
Binder, JR, Swanson, SJ, Hammeke, TAet al. Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology 1996;46: 978–984. CrossRefGoogle ScholarPubMed
Bookheimer, SY. Functional MRI applications in clinical epilepsy. Neuroimage 1996;4: S139–S146. CrossRefGoogle ScholarPubMed
McCarthy, G, Blamire, AM, Rothman, DL, Gruetter, R, Shulman, RG. Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proc Natl Acad Sci USA 1993;90: 4952–4956. CrossRefGoogle ScholarPubMed
Binder, JR, Rao, SM, Hammeke, TAet al. Lateralized human brain language systems demonstrated by task subtraction functional magnetic resonance imaging. Arch Neurol 1995;52: 593–601. CrossRefGoogle ScholarPubMed
Cuenod, CA, Bookheimer, SY, Hertz-Pannier, L, Zeffiro, TA, Theodore, WH, Bihan, D. Functional MRI during word generation, using conventional equipment: a potential tool for language localization in the clinical environment. Neurology 1995;45: 1821–1827. CrossRefGoogle ScholarPubMed
Talairach, J, Tournoux, P. Co-planar stereotactic atlas of the human brain. Stuttgart: Thieme, 1988. Google Scholar
Kriegeskorte, N, Goebel, R. An efficient algorithm for topologically correct segmentation of the cortical sheet in anatomical mr volumes. Neuroimage 2001;14: 329–346. CrossRefGoogle ScholarPubMed
Dale, AM, Fischl, B, Sereno, MI. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999;9: 179–194. CrossRefGoogle ScholarPubMed
Friston, KJ. Models of brain function in neuroimaging. Annu Rev Psychol 2005;56: 57–87. CrossRefGoogle ScholarPubMed
Hammeke, TA, Bellgowan, PS, Binder, JR. fMRI: methodology – cognitive function mapping. Adv Neurol 2000;83: 221–233. Google ScholarPubMed
Lee, CC, Ward, HA, Sharbrough, FWet al. Assessment of functional MR imaging in neurosurgical planning. AJNR Am J Neuroradiol 1999;20: 1511–1519. Google ScholarPubMed
Binder, J. Functional magnetic resonance imaging. Language mapping. Neurosurg Clin N Am 1997;8: 383–392. Google ScholarPubMed
Desmond, JE, Sum, JM, Wagner, ADet al. Functional MRI measurement of language lateralization in Wada-tested patients. Brain 1995;118 (Pt 6):1411–1419. CrossRefGoogle ScholarPubMed
Morris, GL, Mueller, WM, Yetkin, FZet al. Functional magnetic resonance imaging in partial epilepsy. Epilepsia 1994;35: 1194–1198. CrossRefGoogle ScholarPubMed
Engstrom, M, Ragnehed, M, Lundberg, P, Soderfeldt, B. Paradigm design of sensory-motor and language tests in clinical fMRI. Neurophysiol Clin 2004;34: 267–277. CrossRefGoogle ScholarPubMed