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Polymorphisms in genes encoding dopamine signalling pathway and risk of alcohol dependence: a systematic review

Published online by Cambridge University Press:  18 June 2013

Lakkakula V. K. S. Bhaskar  and
Shanmugasundaram Arun Kumar
Lakkakula V. K. S. Bhaskar*
Affiliation:
Department of Biomedical Sciences, Sri Ramachandra University, Chennai, India
Shanmugasundaram Arun Kumar
Affiliation:
Department of Biomedical Sciences, Sri Ramachandra University, Chennai, India
*
Dr. L. V. K. S. Bhaskar, Department of Biomedical Sciences, Sri Ramachandra University, No. 1 Ramachandra Nagar, Porur, Chennai 600 116, India. Tel: +91-44-24768027-33, ext. 8296 or 8297; Fax: +91-44-2476 7008; E-mail: [email protected]
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Abstract

Background

Alcohol dependence (AD) is one of the major elements that significantly influence drinking pattern that provoke the alcohol-induced organ damage. The structural and neurophysiologic abnormalities in the frontal lobes of chronic alcoholics were revealed by magnetic resonance imaging scans. It is well known that candidate genes involved in dopaminergic pathway are of immense interest to the researchers engaged in a wide range of addictive disorders. Dopaminergic pathway gene polymorphisms are being extensively studied with respect to addictive and behavioral disorders.

Methods

From the broad literature available, the current review summarizes the specific polymorphisms of dopaminergic genes that play a role in alcohol dependence.

Results

No evidence indicating any strong association between AD and polymorphisms of dopamine pathway genes has emerged from the literature.

Discussion

Further studies are warranted, considering a range of alcohol-related traits to determine the genes that influence alcohol dependence.

Keywords

addictionalcoholdopaminegene polymorphisms
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 26 , Issue 2 , April 2014 , pp. 69 - 80
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2013 

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