Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-29T17:40:02.337Z Has data issue: false hasContentIssue false
  • English
  • Français

The platelet window: examining receptor regulated second messenger processes in psychosis and depression

Published online by Cambridge University Press:  24 June 2014

M Berk  and
G S Malhi
M Berk*
Affiliation:
Department of Psychiatry, University of Melbourne, Geelong, Victoria
G S Malhi
Affiliation:
Mood Disorders Unit at the Black Dog Institute, University of New South Wales, Sydney, Australia
*
Professor Michael Berk, Department of Psychiatry, University of Melbourne, Swanston Center, PO Box 281, Geelong, Victoria, 3220, Australia. Tel. + 61 35226 7410; Fax: + 61 352267436; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Peripheral markers of psychiatric illness provide a potentially important window into the pathophysiology of a number of psychiatric illnesses. Direct access to pathophysiological processes is fraught with difficulty. However, receptor-regulated second messenger-mediated calcium shifts are an accessible and practical method by which to examine changes in a clinical population. This is possible because platelets and neurons share some physiological features. The platelet intracellular calcium response to receptor stimulation has previously been used as a peripheral marker of psychiatric illness across a range of neurotransmitters, including serotonin, dopamine and glutamate. This review considers the specificity and selectivity of this response and its use in psychotic and mood disorders.

Keywords

intracellular calcium responsemajor depressionperipheral markersplateletpsychiatric illnesspsychosissecond messengers
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 6 , December 2003 , pp. 309 - 315
Copyright
Copyright © 2003 Blackwell Munksgaard

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Pearse, AGE. The diffuse neuroendocrine system: Peptides,amines,placodes and the APUD theory. Progr Brain Res 1986;68: 25–31. CrossRefGoogle ScholarPubMed
Lesch, KP, Wolozin, BL, Murphy, DLet al. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem 1993;60: 2319–2322.CrossRefGoogle ScholarPubMed
Stahl, SM. The human platelet. A disgnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Arch General Psychiatry 1977;34: 509–516. CrossRefGoogle Scholar
Da Prada, M, Cesura, AM, Launay, JMet al. Platelets as a model for neurones? Experentia 1988;44: 115–126. CrossRefGoogle ScholarPubMed
Berk, M, Bodemer, W, Van Oudenhove, Tet al. Dopamine increases platelet intracellular calcium in bipolar disorder and controls. Int Clin Pharmacol 1994;9: 291–293. Google ScholarPubMed
Plein, H, Berk, M. The platelet as a peripheral marker in psychiatric illness. Hum Psychopharmacol 2001;16: 229–236.CrossRefGoogle ScholarPubMed
Leonard, BE. Fundamentals of Psychopharmacology. Chichester: John Wiley, 1992. Google Scholar
Arolt, V, Rothermundt, M, Peters, M, Leonard, B. Immunological research in clinical psychiatry: report on the consensus debate during the 7th expert meeting on psychiatry and immunology. Mol Psychiatry 2002;7: 822–826.CrossRefGoogle ScholarPubMed
Dubovsky, SL, Christiano, J, Daniell, LCet al. Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch General Psychiatry 1989;46: 632–638. CrossRefGoogle ScholarPubMed
Bowden, CL, Huang, LG, Javors, MAet al. Calcium function in affective disorders and healthy controls. Biol Psychiatry 1988;23: 367–376.CrossRefGoogle ScholarPubMed
Dubovsky, SL, Lee, C, Christiano, J, Murphy, J. Elevated platelet intracellular calcium concentration in bipolar depression. Biol Psychiatry 1991;29: 441–450.CrossRefGoogle ScholarPubMed
Berk, M, Bodemer, W, Van Oudenhove, T, Butkow, N. The platelet intracellular calcium response to serotonin is augmented in bipolar manic and depressed patients. Hum Psychopharmacol Clin Exp 1995;10: 189–193. CrossRefGoogle Scholar
Dubovsky, SL, Murphy, J, Thomas, M, Rademacher, J. Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am J Psychiatry 1992;149: 118–120.Google ScholarPubMed
Emamghoreishi, M, Schlichter, L, Li, PPet al. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder. Am J Psychiatry 1997;154: 976–982.Google ScholarPubMed
Walton, SA, Berk, M, Brook, S. Superiority of lithium over verapamil in mania: a randomised controlled single blind trial. J Clin Psychiatry 1996;57: 543–546.CrossRefGoogle Scholar
Tan, Ch, Javors, MA, Seleshi, E, Lowrimore, PA, Bowden, CL. Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. Life Sci 1990;46: 1175–1180.CrossRefGoogle ScholarPubMed
Berk, M, Kirchmann, Nh, Butkow, N. Lithium blocks 45Ca2+ uptake into platelets in bipolar disorder and controls. Clin Neuropharmacol, 1996;19: 48–51.CrossRefGoogle ScholarPubMed
Arora, RC, Meltzer, HY. Increased serotonin 2 receptor binding as measured by 3H-LSD binding in blood platelets of depressed patients. Life Sci 1989;44: 725–734.CrossRefGoogle Scholar
Arora, RC, Meltzer, HY. Serotonin 2 receptor binding in blood platelets of schizophrenic patients. Psychiatr Res 1993;47: 111–119. CrossRefGoogle ScholarPubMed
Bakish, D, Cavazzoni, P, Chudzik, Jet al. Effects of serotonin reuptske inhibitors on platelet serotonin parameters in major depressive disorder. Biol Psychiatry 1997;41: 184–190.CrossRefGoogle ScholarPubMed
Biegon, A, Grinspoon, A, Blumenfeld, Bet al. Increased serotonin 5HT2 receptor binding on blood platelets of suicidal men. Psychopharmacol (Berl) 1990;100: 165–167. CrossRefGoogle Scholar
Butler, J, O'Halloran, A, Leonard, BE. The Galway study of panic disorder II. Changes in some peripheral markers of noradrenergic and serotonergic function in DSM III-R panic disorder. J Affect Disord 1992;26: 89–99.CrossRefGoogle ScholarPubMed
Nugent, DF, Dinan, TG, Leonard, BE. Further characterization of the inhibition of platelet aggregation by a plasma factor(s) in unmedicated unipolar depressed patients. J Affect Disord 1995;33: 227–231.CrossRefGoogle Scholar
Hrdina, PD, Bakish, D, Ravindran, Aet al. Platelet serotonergic indices in major depression: up-regulation of 5HT2A receptors unchanged by antidepressant treatment. Psychiatr Res 1997;66: 73–85. CrossRefGoogle Scholar
Alvarez, JC, Gluck, N, Arnulf, Iet al. Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine. Clin Pharmacol Therap 1999;66: 617–624. CrossRefGoogle ScholarPubMed
Mendelson, SD. The current status of the platelet 5-HT(2A) receptor in depression. J Affect Disord 2000;57: 13–24.CrossRefGoogle ScholarPubMed
Kusumi, I. Serotonin-2 receptor-mediated intraplatelet calcium mobilization in affective disorders: relevance to the pathophysiology of depression. Hokkaido Igaku Zasshi 1993;68: 325–336.Google ScholarPubMed
Mikuni, M, Kagaya, A, Takahashi, Ket al. Serotonin but not norepinephrine induced calcium mobilization of platelets is enhanced in affective disorders. Psychopharmacol 1992;106: 311–314. CrossRefGoogle Scholar
Grynkiewicz, G, Poenie, M, Tsien, RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260: 3440–3450.Google ScholarPubMed
Plein, H, Berk, M, Eppel, S, Butkow, N. Augmented platelet calcium uptake in response to serotonin stimulation in patients with major depression measured using Mn2+ influx and 45Ca2+ uptake. Life Sci 2000;66: 425–431.CrossRefGoogle Scholar
Tomiyoshi, R, Kamei, K, Muraoka, S, Muneoka, K, Takigawa, M. Serotonin-induced platelet intracellular Ca2+ responses in untreated depressed patients and imipramine responders in remission. Biol Psychiatry 1999;45: 1042–1048.CrossRefGoogle ScholarPubMed
Delisi, SM, Konopka, LM, O'Connor, FL, Crayton, JW. Platelet cytosolic calcium responses to serotonin in depressed patients and controls: relationship to symptomatology and medication. Biol Psychiatry 1998;43: 327–334.CrossRefGoogle ScholarPubMed
Kusumi, I, Koyama, T, Yamashita, I. Serotonin-induced platelet intracellular calcium mobilization in depressed patients. Psychopharmacol (Berl) 1994;113: 322–327. CrossRefGoogle ScholarPubMed
Kusumi, I, Suzuki, K, Sasaki, Y, Kameda, K, Koyama, T. Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin. Neuropsychopharmacology 2000;23: 690–696.CrossRefGoogle ScholarPubMed
Tollefson, GD, Heiligenstein, JH, Tollefson, SL, Birkett, MA, Knight, DL, Nemeroff, CB. Is there a relationship between baseline and treatment-associated changes in [3H]-IMI platelet binding and clinical response in depression? Neuropsychopharmacology 1996;14: 47–53.CrossRefGoogle Scholar
Figueras, G, Perez, V, San Martino, O, Alvarez, E, Grupo de, F. Pretreatment platelet 5HT concentration predicts the short term response to paroxetine in major depression. Biol Psychiatry 1999;46: 518–524.CrossRefGoogle Scholar
Neuger, J, Wisted, B, Sinner, B, Aberg-Wisted, A, Stain-Malmgren, R. The effect of citalopram treatment on platelet serotonin function in panic disorders. Int Clin Psychopharmacol 2000;15: 83–91.CrossRefGoogle ScholarPubMed
Markovitz, Jh, Shuster, JL, Chitwood, WS, May, RS, Tolbert, LC. Platelet activation in depression and effects of sertraline treatment: an open label study. Am J Psychiatry 2000;157: 1006–1008.CrossRefGoogle Scholar
Musselman, DL, Marzec, UM, Manatunga, Aet al. Platelet reactivity in depressed patients treated with paroxetine. Arch General Psychiatry 2000;57: 875–882. CrossRefGoogle ScholarPubMed
Berridge, MJ. Cytoplasmic calcium oscillations: a two pool model. Cell Calcium 1991;12: 63–72.CrossRefGoogle ScholarPubMed
Konopka, LM, Cooper, R, Crayton, JW. Serotonin-induced increases in platelet cytosolic calcium in depressives, schizophrenic, and substance abuse patients. Biol Psychiatry 1996;39: 708–713.CrossRefGoogle Scholar
Okamoto, Y, Kagaya, A, Tamiya, Set al. Serotonin-induced platelet calcium mobilisation is enhanced in bulimia nervosa but not anorexia nervosa. Biol Psychiatry 1995;38: 274–276.CrossRefGoogle Scholar
Berk, M, Mitchell, VS, Plein, H. The platelet intracellular calcium response to serotonin in subsyndromal depression. Int Clin Psychopharmacol 1998;13: 107–110.CrossRefGoogle ScholarPubMed
Kessler, RC, Zhao, S, Blazer, DG, Swartz, M. Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey. J Affect Disord 1997;45: 19–30.CrossRefGoogle ScholarPubMed
Peirson, AR, Heuchert, JW. Correlations for serotonin levels and measures of mood in a nonclinical sample. Psychol Rep 2000;87: 707–716.CrossRefGoogle Scholar
Suzuki, K, Kusumi, I, Sasaki, Y, Koyama, T. Serotonin-induced platelet intracellular calcium mobilization in various psychiatric disorders: is it specific to bipolar disorder? J Affect Disord 2001;64: 291–296.CrossRefGoogle ScholarPubMed
Yamawaki, S, Kagaya, A, Okamoto, Y, Shimizu, M, Nishida, A, Uchitomi, Y. Enhanced calcium response to serotonin in platelets from patients with affective disorders. J Psychiatry Neurosci 1996;21: 321–324.Google ScholarPubMed
Bothwell, RA, Eccleston, D, Marshall, E. Platelet intracellular calcium in patients with recurrent affective disorders. Psychopharmacology (Berl) 1994;114: 375–381.CrossRefGoogle ScholarPubMed
Plein, H, Berk, M. The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder. Eur Neuropsychopharmacol 1999;9: 107–110.CrossRefGoogle ScholarPubMed
Almazov, VA, Popov, YG, Gorodinskii, AIet al. Sites of high affinity binding of L-[3H]-glutamic acid in human platelets. New type of platelet receptors? Biokimiya 1988;53: 848–852. Google Scholar
Grant, ER, Bacskai, BJ, Pleasure, DEet al. N-methyl-D-aspartate receptors expressed in a non-neuronal cell line mediate subunit-specific increases in free intracellular calcium. J Biol Chem 1997;272: 647–656.CrossRefGoogle Scholar
Mangano, RM, Schwarcz, R. The human platelet as a model for the glutamatergic neuron: Platelet uptake of 1-glutamate. J Neurochem 1981;36: 1067–1076.CrossRefGoogle Scholar
Kim, JS, Kornhuber, Hh, Schmid- Burgk, Wet al. Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 1980;20: 379–382.CrossRefGoogle Scholar
Tsai, G, Passani, LA, Slusher, BSet al. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains Arch General Psychiatry 1995;52: 829–836. CrossRefGoogle ScholarPubMed
Berk, M, Plein, H, Czismadia, T. Supersensitive platelet glutamate receptors as a possible peripheral marker in schizophrenia. Int Clin Psychopharmacol 1999;14: 119–122.CrossRefGoogle Scholar
Berk, M, Plein, H, Belsham, B. The specificity of the platelet glutamate receptor supersensitivity in psychotic disorders. Life Sci 2000;66: 2427–2432.CrossRefGoogle ScholarPubMed
Berk, M, Plein, H, Ferreira, D. Platelet glutamate supersensitivity in depression. Int J Neuropsychopharmacol 2000;3: S112. Google Scholar
Sarges, R, Howard, HR, Browne, RG, Lebel, LA, Seymour, PA, Koe, BK. 4-amino[1,2,4]triazolo[4 3a] quinoxalines: a novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. J Med Chem 1990;33: 2240–2254.CrossRefGoogle ScholarPubMed
Williams, M. Adenosine: The prototypic neuromodulator. Neurochem Inter, 1989;14: 249–264. CrossRefGoogle ScholarPubMed
Stone, TW, Taylor, DA. Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex. Neurosci Lett, 1979;11: 93–97.CrossRefGoogle ScholarPubMed
Sheid, B. Trazodone, a non-tricyclic antidepressant, is an inhibitor of adenosine deaminease. Res Commum Chem Pathol Pharmacol 1985;47: 149–152. Google Scholar
Jonzon, B, Fredholm, BB. Adenosine mechanisms are not affected by antidepressant concentrations of desipramine. J Pharm Pharmacol, 1984;36: 846–848.CrossRefGoogle Scholar
Williams, M, Risley, EA, Robinson, JL. Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex. Neurosci Lett 1983;35: 47–51.CrossRefGoogle Scholar
Berk, M, Plein, H, Ferreira, D, Jersky, B. Blunted adenosine A2a receptor function in platelets in patients with major depression. Eur Neuropsychopharmacol 2001;11: 183–186.CrossRefGoogle ScholarPubMed