Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-10T18:57:07.169Z Has data issue: false hasContentIssue false
  • English
  • Français

Nutritional manipulation and psychiatric conditions: focus on mood and cognition

Published online by Cambridge University Press:  24 June 2014

W. J. Riedel ,
B. L. Jorissen  and
E. Hogervorst
W. J. Riedel*
Affiliation:
Experimental Psychopharmacology Unit, Brain and Behavior Institute, Universiteit Maastricht
B. L. Jorissen
Affiliation:
Experimental Psychopharmacology Unit, Brain and Behavior Institute, Universiteit Maastricht
E. Hogervorst
Affiliation:
Oxford Project to Investigate Memory and Aging (OPTIMA), Radcliffe Infirmary, Department of Pharmacology, Oxford, UK
*
Wim Riedel, GSK, Addenbrooke's Hospital, Box 128, Hills Road, Cambridge CB2 2GG, UK. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

In this paper, several experimental models of human depression and cognitive dysfunction, which are designed specifically to mimic the proposed mechanisms of action of many nutritional supplements, are illustrated. These mechanisms of interest are antioxidant effects, glucose utilization, neuronal membrane function and neurotransmitter effects, with particular reference to nutrient-based amino acid manipulations of neurotransmission, such as tryptophan depletion. It is concluded that the application of experimental human models of altered mood and cognitive function may illuminate substantially the quest for nutritional enhancement of human mood and cognitive function.

Keywords

nutritioncognitionmoodhuman models of psychopathology
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 1 , February 2003 , pp. 4 - 7
Copyright
Copyright © 2003 Blackwell Munksgaard

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Riedel, WJ & Jorissen, BL. Nutrients, age and cognitive function. Curr Opin Clin Nutr Metab Care 1998; 1: 579–585.CrossRefGoogle ScholarPubMed
Ames, BN. Micronutrients prevent cancer and delay aging. Toxicol Lett 1998;102–103: 5–18. CrossRefGoogle ScholarPubMed
Saletu, B & Grünberger, J. The hypoxia model in human psychopharmacology: neuropsychological and psychometric studies with aniracetam. Hum Neurobiol 1984;3: 171–181.Google Scholar
Hogervorst, E. Age-related cognitive decline and cognition enhancers. Maastricht: Neuropsych Publishers, 1998. Google Scholar
Saletu, B, Grunberger, J, Anderer, R. On brain protection of co-dergocrine mesylate (Hydergine) against hypoxic hypoxidosis of different severity: double-blind placebo-controlled quantitative EEG and psychometric studies. Int J Clin Pharmacol Ther Toxicol 1990; 28: 510–524.Google ScholarPubMed
Bahrke, MS & Shukitt, HB. Effects of altitude on mood, behaviour and cognitive functioning. A review. Sports Med 1993;16: 97–125.CrossRefGoogle ScholarPubMed
Scholey, AB, Moss, MC, Wesnes, K. Oxygen and cognitive performance: the temporal relationship between hyperoxia and enhanced memory. Psychopharmacology 1998;140: 123–126.CrossRefGoogle ScholarPubMed
Scholey, AB, Moss, MC, Neave, N, Wesnes, K. Cognitive performance, hyperoxia, and heart rate following oxygen administration in healthy young adults. Physiol Behav 1999;67: 783–789.CrossRefGoogle ScholarPubMed
Riedel, WJ, Jolles, J. Cognition enhancers in age-related cognitive decline. Drugs Aging 1996;8: 245–274.CrossRefGoogle ScholarPubMed
Kaplan, RJ & Greenwood, CE. Dietary saturated fatty acids and brain function. Neurochem Res 1995; 23: 615–626. CrossRefGoogle ScholarPubMed
Benton, D, Owens, DS. Blood glucose and human memory. Psychopharmacology 1993;113: 83–88.CrossRefGoogle ScholarPubMed
Breier, A, Buchanan, RW. The effects of metabolic stress on plasma progestrone in healthy volunteers and shizofrenic patients. Life Sci 1992;51: 1527–1534.CrossRefGoogle Scholar
Breier, A, Davis, OR, Buchanan, RW, Moricle, LA, Munson, RC. Effects of metabolic pertubation on plasma homovanillic acid in schizophrenia. Relationship to prefrontal cortex volume. Arch Gen Psychiatry 1993;50: 541–550.CrossRefGoogle Scholar
Fowler, B, Hofer, K, Lipitkas, J. The exhaustive additivity displayed by nitrous oxide has implications for cognitive–energetical theory. Biol Psychol 2000;52: 161–180.CrossRefGoogle ScholarPubMed
Jorissen, B, Brouns, F, Van Boxtel, MPJ, Ponds, RWH M, Verhey, FRJ, Jolles, J, Riedel, WJ. The influence of plant-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci 2002;4: 121–134. CrossRefGoogle Scholar
Yehuda, S, Rabinovitz, S, Mostofsky, DI. Essential fatty acids are mediators of brain biochemistry and cognitive functions. J Neurosci Res 1999;56: 565–570.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Kalmijn, S, Feskens, EJM, Launer, LJ, Kromhout, D. Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 1997;145: 33–41.CrossRefGoogle ScholarPubMed
Riedel, WJ, Klaassen, T, Schmitt, JAJ. Tryptophan, mood and cognitive function. Brain Behav Immun 2002;16: 581–589.CrossRefGoogle ScholarPubMed
Markus, CR, Panhuysen, G, Tuiten, A, Koppeshaar, H, Fekkes, D, Peters, ML. Does carbohydrate-rich, protein-poor food prevent a deterioration of mood and cognitive performance of stress-prone subjects when subjected to a stressful task? Appetite 1998; 31: 49–65.CrossRefGoogle ScholarPubMed
Markus, CR, Olivier, B, Panhuysen, GEMet al. The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr 2000; 71: 1536–1544.Google Scholar
Moja, EA, Lucini, V, Benedetti, F, Lucca, A. Decrease in plasma phenylalanine and tyrosine after phenylalanine-tyrosine free amino acid solutions in man. Life Sci 1996; 58: 2389–2395.CrossRefGoogle ScholarPubMed
Leyton, M, Young, SN, Pihl, ROet al. Effects on mood of acute phenylalanine/ tyrosine depletion in healthy women. Neuropsychopharmacology 2002;22: 52–63. CrossRefGoogle ScholarPubMed
McTavish, SF, McPherson, MH, Harmer, CJet al. Antidopaminergic effects of dietary tyrosine depletion in healthy subjects and patients with manic illness. Br J Psychiatry 2001;179: 356–360.CrossRefGoogle ScholarPubMed
Deijen, JB, Wientjes, CJ, Vullinghs, HF, Cloin, PA, Langefeld, JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull 1999;48: 203–209.CrossRefGoogle ScholarPubMed