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Neuroanatomical assessment of the impact of negative emotion on implicit memory in patients with obsessive compulsive disorder

Published online by Cambridge University Press:  15 January 2016

Shin-Eui Park ,
Jong-Chul Yang  and
Gwang-Woo Jeong
Shin-Eui Park
Affiliation:
Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, Republic of Korea
Jong-Chul Yang*
Affiliation:
Department of Psychiatry, Chonbuk National University Medical School, Jeonju, Republic of Korea
Gwang-Woo Jeong*
Affiliation:
Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, Republic of Korea Department of Radiology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea
*
Prof. Gwang-Woo Jeong, Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, # 42 Jebongro, Dong-gu, Gwangju 501-757, Republic of Korea. Tel: +(82-62) 220-5881; Fax: (82-62) 226-4380; E-mail: [email protected]
Prof. Gwang-Woo Jeong, Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, # 42 Jebongro, Dong-gu, Gwangju 501-757, Republic of Korea. Tel: +(82-62) 220-5881; Fax: (82-62) 226-4380; E-mail: [email protected]
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Abstract

Objective

We performed functional magnetic resonance imaging (fMRI) to discriminate the differential brain activation patterns in patients with obsessive compulsive disorder (OCD) and healthy controls during implicit retrieval tasks with emotionally neutral and unpleasant words.

Methods

Sixteen patients with OCD (mean age: 31.4±10.1 years) and 16 healthy controls (mean age: 32.6±5.8 years) with no history of neurological or psychiatric illness underwent 3-T fMRI. The stimulation paradigm consisted of the following cycle: rest, encoding of a string of two-syllable words, rest, and retrieval of the previously encoded words with the first consonant omitted.

Results

During the implicit retrieval task with emotionally neutral words, no distinct brain activity was observed in either the patients with OCD or healthy controls. On the other hand, during the retrieval task with unpleasant words, the patients with OCD showed predominant activity in the superior/middle temporal pole, medial superior frontal gyrus, and orbitofrontal cortex (uncorrected p<0.001, extent threshold: 30 voxels), whereas the healthy controls did not show any distinct regions of activation.

Conclusion

This study revealed the differential brain activation patterns between patients with OCD and healthy controls during implicit memory tasks with unpleasant words. Our results suggest that the impact of negative emotion on implicit memory task may be associated with the symptomatology of OCD. This finding may be helpful for understanding the neural mechanisms that underlie implicit memory retrieval, particularly the interaction between emotion and cognition, in patients with OCD.

Keywords

functional magnetic resonance imaging (fMRI)implicit memoryobsessive compulsive disorder (OCD)
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 28 , Issue 4 , August 2016 , pp. 206 - 213
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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References

1. Zohar, J, Chopra, M, Sasson, Y et al. Obsessive compulsive disorder: serotonin and beyond. World J Biol Psychiatry 2000;1:92–100.CrossRefGoogle ScholarPubMed
2. Greist, JH, Jefferson, JW, Kobak, KA et al. Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis. Arch Gen Psychiatry 1995;52:53–60.CrossRefGoogle ScholarPubMed
3. Kuelz, AK, Hohagen, F, Voderholzer, U. Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol 2004;65:185–236.CrossRefGoogle ScholarPubMed
4. Muller, J, Roberts, JE. Memory and attention in obsessive-compulsive disorder: review. J Anxiety Disord 2005;19:1–28.CrossRefGoogle Scholar
5. Manenti, R, Tettamanti, M, Cotelli, M, Miniussi, C, Cappa, SF. The neural bases of word encoding and retrieval: a fMRI-guided transcranial magnetic stimulation study. Brain Topogr 2010;22:318–332.CrossRefGoogle ScholarPubMed
6. Schacter, DL, Wagner, AD, Buckner, RL. Memory systems of 1999. In: Tulving E, Craik FI, editors. The Oxford handbook of memory. New York, US: Oxford University Press, 2000; p. 627–643.CrossRefGoogle Scholar
7. Schacter, DL. Implicit memory: history and current status. J Exp Psychol 1987;13:501–518.Google Scholar
8. Christensen, KJ, Kim, SW, Dysken, MW, Hoover, KM. Neuropsychological performance in obsessive-compulsive disorder. Biol Psychiatry 1992;31:4–18.CrossRefGoogle ScholarPubMed
9. Deckersbach, T, Savage, CR, Curran, T et al. A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorder. Am J Psychiatry 2002;159:1780–1782.CrossRefGoogle ScholarPubMed
10. Roth, RM, Baribeau, J, Milovan, D, O’Connor, K, Todorov, C. Procedural and declarative memory in obsessive-compulsive disorder. J Int Neuropsychol Soc 2004;10:647–654.CrossRefGoogle ScholarPubMed
11. Rauch, SL, Whalen, PJ, Curran, T et al. Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods. Adv Neurol 2001;85:207–224.Google ScholarPubMed
12. Komatsu, S, Naito, M, Fuke, T. Age-related and intelligence-related differences in implicit memory: effects of generation on a word-fragment completion test. J Exp Child Psychol 1996;62:151–172.CrossRefGoogle ScholarPubMed
13. Rauch, SL, Wedig, MM, Wright, CI et al. Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive–compulsive disorder: fMRI. Biol Psychiatry 2007;61:330–336.CrossRefGoogle Scholar
14. Valerius, G, Lumpp, A, Kuelz, AK et al. Reversal learning as a neuropsychological indicator for the neuropathology of obsessive compulsive disorder? A behavioral study. J Neuropsychiatry Clin Neurosci 2008;20:210–218.CrossRefGoogle ScholarPubMed
15. Goodman, WK, Price, LH, Rasmussen, SA et al. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry 1989;46:1012–1016.CrossRefGoogle ScholarPubMed
16. Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.CrossRefGoogle ScholarPubMed
17. Maier, W, Buller, R, Philipp, M, Heuser, I. The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders. J Affect Disord 1988;14:61–68.CrossRefGoogle ScholarPubMed
18. Jeong, GW, Park, K, Youn, G et al. Assessment of cerebrocortical regions associated with sexual arousal in premenopausal and menopausal women by using BOLD-based functional MRI. J Sex Med 2005;2:645–651.CrossRefGoogle ScholarPubMed
19. Fletcher, P, Stephenson, C, Bullmore, E, Donovan, T, Williams, E, Carpenter, A. Brain regions predicting subsequent episodic and implicit memory for words. A dissociation measured using fMRI. NeuroImage 2001;13(Supp1.):S666–S666.CrossRefGoogle Scholar
20. Milad, MR, Rauch, SL. Obsessive compulsive disorder: beyond segregated cortico striatal pathway. Trends Cogn Sci 2012;16:43–51.CrossRefGoogle Scholar
21. Shapira, NA, Liu, Y, He, AG et al. Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. Biol Psychiatry 2003;54:751–756.CrossRefGoogle ScholarPubMed
22. Valente, AA Jr, Miguel, EC, Castro, CC et al. Regional gray matter abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study. Biol Psychiatry 2005;58:479–487.CrossRefGoogle ScholarPubMed
23. du Boisgueheneuc, F, Levy, R, Volle, E et al. Functions of the left superior frontal gyrus in humans: a lesion study. Brain 2006;129:3315–3328.CrossRefGoogle ScholarPubMed
24. Corcoran, KM, Woody, SR, Tolin, DF. Recognition of facial expressions in obsessive-compulsive disorder. J Anxiety Disord 2008;22:56–66.CrossRefGoogle ScholarPubMed
25. Volkow, ND, Fowler, JS. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex 2000;10:318–325.CrossRefGoogle ScholarPubMed
26. Rule, RR, Shimamura, AP, Knight, RT. Orbitofrontal cortex and dynamic filtering of emotional stimuli. Cogn Affect Behav Neurosci 2002;2:264–270.CrossRefGoogle ScholarPubMed
27. Nelson, EE, McClure, EB, Monk, CS et al. Developmental differences in neuronal engagement during implicit encoding of emotional faces: an event-related fMRI study. J Child Psychol Psychiatry 2003;44:1015–1024.CrossRefGoogle ScholarPubMed
28. Dolan, RJ, Lane, R, Chua, P, Fletcher, P. Dissociable temporal lobe activations during emotional episodic memory retrieval. Neuroimage 2000;11:203–209.CrossRefGoogle ScholarPubMed
29. Weber, B, Kügler, F, Elger, CE. Comparison of implicit memory encoding paradigms for the activation of mediotemporal structures. Epilepsy Behav 2007;10:442–448.CrossRefGoogle ScholarPubMed
30. Gazzaniga, MS. The social brain. New York: Basic Books, 1985.Google Scholar
31. Scott, SK, Blank, CC, Rosen, S, Wise, RJ. Identification of a pathway for intelligible speech in the left temporal lobe. Brain 2000;123:2400–2406.CrossRefGoogle ScholarPubMed
32. Feygin, DL, Swain, JE, Leckman, JF. The normalcy of neurosis: evolutionary origins of obsessive-compulsive disorder and related behaviors. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:854–864.CrossRefGoogle ScholarPubMed