Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-24T09:17:17.988Z Has data issue: false hasContentIssue false
  • English
  • Français

Monoamines and CSF: relevance to neuropsychiatric disorders

Published online by Cambridge University Press:  18 September 2015

W.M.A. Verhoeven
Get access Rights & Permissions [Opens in a new window]

Summary

Over the past 25 years much effort has been put into the research of the relationship between neuropsychiatric disorders and the concentrations of CSF-monoamine metabolites. Most of this research has beenfocused on the relation between CSF-concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) and specific symptomatological entities, particularly schizophrenia, Alzheimer's dementia and endogenous depression. It appeared that specific relations between diseases and CSF-concentrations of monoamine metabolites cannot be longer maintained and that a more functional psychopathology should be considered as the future research strategy.

Keywords

DementiadepressionschizophreniaHVA5-HIAACSFDementiedepressieschizofrenieHVZ5-HIAZliquor
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 4 , Issue 3 , September 1992 , pp. 47 - 51
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literatuur

1.Van Praag, HM.De plaats van de biologische psychiatrie binnen de psychiatrische wetenschappen. Ned Tijdsch Geneesk 1970; 114: 834–8.Google Scholar
2.Van Praag, HM, Korf, J en Puite, J.5-Hydroxyindoleacetic acid levels in the cerebrospinal fluid of depressive patients treated with probenecid. Nature 1970; 225: 1259–60.CrossRefGoogle ScholarPubMed
3.Post, RM en Goodwin, FK.Effects of amitriptyline and imipramine on amine metabolites in the cerebrospinal fluid of depressed patients. Arch gen Psychiat 1974; 30: 234–9.CrossRefGoogle ScholarPubMed
4.Asberg, M, Bertilsson, L, Tuck, D, Cronholm, B en Sjöqvist, F.Indoleamine metabolites in the cerebrospinal fluid of depressed patients before and during treatment with nortriptyline. Clin Pharmacol Ther 1973; 14: 277–86.CrossRefGoogle ScholarPubMed
5.Martensson, B, Wagner, A, Beck, O, Brodin, K, Montero, D en Asberg, M.Effects of clomipramine treatment on cerebrospinal fluid monoamine metabolites and platelet H-imipramine binding and serotonin uptake and concentration in major depressive disorder. Acta psychiat scand 1991; 83: 125–33.CrossRefGoogle Scholar
6.Van Praag, HM, Verhoeven, WMA en Kahn, RS.Psychofarmaca, een Leidraad voor de praktiserende Medicus. Assen/Maastricht, Van Gorcum 1988; 154–62.Google Scholar
7.Gottfries, CG, Gottfries, I, Johansson, B, Olsson, R, Persson, T, Roos, BE en Sjöström, R.Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex. Neuropharmacol 1971; 10: 665–72.CrossRefGoogle ScholarPubMed
8.Westenberg, HGM en Verhoeven, WMA.CSF monoamine metabolites in dementia of the Alzheimer type and controls: evidence for lower levels of homovanillic acid and 5-hydroxyindole-acetic acid in patients. Int J geriatr Psychiat 1988; 3: 281–8.CrossRefGoogle Scholar
9.Van Praag, HM en Leijnse, B.Neubewertung des Syndroms. Skizze einer functionellen Pathologic Psychiat Neurol Neurochir 1965; 68: 50–66.Google Scholar
10.Van Praag, HM, Asnis, GM, Kahn, GS, Brown, SL, Harkavy, JM, Friedman, JMH en Wetzler, S.Monoamines and abnormal behaviour, a multi-aminergic perspective. Br J Psychiat 1990; 157: 723–34.CrossRefGoogle ScholarPubMed
11.Van Praag, HM.Two-tier Diagnosing in Psychiatry. Psychiat Res 1990; 34: 1–11.CrossRefGoogle ScholarPubMed
12.Bowers, MB.Central dopamine turnover in schizophrenic syndromes. Arch gen Psychiat 1974; 31: 50–4.CrossRefGoogle ScholarPubMed
13.Lindstrom, LA.Low HVA and normal 5-HIAA CSF levels in drug-free schizophrenic patients compared to healthy volunteers: correlations to symptomatology and family history. Psychiat Res 1985; 41: 265–73.CrossRefGoogle Scholar
14.Csernansky, JG, King, RJ, Faustman, WO, Moses, JA Jr, Poscher, ME en Faull, KM.5-HIAA in cerebrospinal fluid and deficit schizophrenic characteristics. Br J Psychiat 1990; 156: 501–7.CrossRefGoogle ScholarPubMed
15.Van Praag, HM, Korf, J, Lakke, JPWF en Schut, T.Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. Psychol Med 1975; 5: 138–46.CrossRefGoogle Scholar
16.Gattaz, WF, Waldmijer, P en Beckman, H.CSF monoamine metabolites in schizoprenic patients. Acta psychiat scand 1982; 66: 350–60.CrossRefGoogle Scholar
17.Gottfries, CG, Gottfries, I en Roos, BD.Homovanilic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid related to rated mental and motor impairment in senile and presenile dementia. Acta psychiat scand 1970; 46: 99–105.Google ScholarPubMed
18.Agren, H, Mefford, IN, Rudorfer, MV, Linnoila, M en Potter, WZ.Interacting neurotransmitter systems. A non- experimental approach to the 5 HIAA-HVA correlation in human CSF. J psychiat Res 1986; 20: 175–93.CrossRefGoogle Scholar
19.Van Praag, HM en Korf, J.Endogenous depressions with and without disturbances in the 5-hydroxytryptamine metabolism: a biochemical classification? Psychopharmacol 1971; 19: 148–52.CrossRefGoogle Scholar
20.Banki, CM.Correlation between CSF metabolites and psychomotor activity in affective disorders. J Neurochem 1977; 28: 255–7.CrossRefGoogle Scholar
21.Ashcroft, GW, Carwford, TBB en Eccleston, D.5-Hydroxyindole compounds in the cerebrospinal fluid of patients with psychiatric or neurological diseases. Lancet 1966; 2: 1049–50.CrossRefGoogle ScholarPubMed
22.Van Praag, HM en De Haan, S.Central serotonin metabolism and the frequency of depression. Psychiat Res 1979; 1: 219–24.CrossRefGoogle ScholarPubMed
23.Asberg, M, Thoren, P, Träskman, LH, Bertilsson, L en Ringbergen, V. ‘Serotonin depression’- A biochemical subgroup within the affective disorders? Science 1976; 191: 478–80.CrossRefGoogle ScholarPubMed
24.Asberg, M, Träskman, L en Thoren, P.5-HIAA cerebrospinal fluid. A biochemical suicide predictor? Arch gen Psychiat 1976; 33: 1193–7.CrossRefGoogle ScholarPubMed
25.Westenberg, HGM en Verhoeven, WMA.CSF monoamine metabolites in patients and controls: support for bimodal distribution in major affective disorders. Acta psychiatr scand 1988; 78: 541–49.CrossRefGoogle ScholarPubMed
26.Gibbons, RD en Davis, JM.Consistent evidence for a biological subtype of depression characterized by low CSF monoamine levels. Acta psychiat scand 1986; 74: 8–12CrossRefGoogle ScholarPubMed