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Meta-analysis of the HTR2A–1354C/T polymorphism in schizophrenia and bipolar disorder

Published online by Cambridge University Press:  23 May 2013

Lian Gu ,
Jinjing Tan ,
Li Su ,
Yuwang Qin ,
Jianxiong Long ,
Qing Chen ,
Juanjuan Xie ,
Baoyun liang ,
Yan Yan  and
Guangliang Wu
Lian Gu*
Affiliation:
Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Jinjing Tan
Affiliation:
Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Li Su
Affiliation:
School of Public Health of Guangxi Medical University, Nanning, Guangxi, China
Yuwang Qin*
Affiliation:
Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Jianxiong Long
Affiliation:
School of Public Health of Guangxi Medical University, Nanning, Guangxi, China
Qing Chen
Affiliation:
Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Juanjuan Xie
Affiliation:
Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Baoyun liang
Affiliation:
Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Yan Yan
Affiliation:
Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
Guangliang Wu
Affiliation:
Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China
*
Lian Gu, Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China. E-mail: [email protected]
Yuwang Qin, Guangxi University of Chinese Medicine, 179 Mingxiu East Road, Nanning, Guangxi, China. E-mail: [email protected]
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Abstract

Objective

Schizophrenia (SCZ) and bipolar disorder (BD) are common psychotic disorders, which show some overlaps in genetic aetiology. Researchers have conducted a number of studies to investigate the relationship between SCZ and the 1354C/T genetic polymorphism of 5-hydroxytryptamine receptor 2A (HTR2A–1354C/T), as well as the associations between BD and the HTR2A–1354C/T polymorphism. However, the results were conflicting. To provide a more robust estimate about the effects of the HTR2A–1354C/T polymorphism on the risk of these two psychotic disorders, we performed this meta-analysis.

Methods

We used the pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) to investigate the relationships between SCZ and the 1354C/T polymorphism of HTR2A, as well as the associations between BD and HTR2A–1354C/T. Publication bias was tested by Begg's test and inverted funnel plot, and heterogeneity was checked by Cochran's Q statistic and the inconsistency index (I2).

Results

Eight studies were concerned with SCZ, analysing a cumulative total of 2953 cases and 3153 controls; six papers studied BD, using a total of 923 cases and 928 controls. There was no significant association found between HTR2A–1354C/T and SCZ in the overall population (T allele vs. C allele, OR = 1.035, 95% CI 0.912–1.175, p = 0.596) or in the subgroups Caucasian population and Asian population. Moreover, there was no significant association between the HTR2A–1354C/T polymorphism and BD in the overall population (T allele vs. C allele, OR = 1.038, 95% CI = 0.607–1.772, p = 0.892).

Conclusion

On the basis of these results, the HTR2A–1354C/T polymorphism is unlikely to be a risk factor for SCZ and BD.

Keywords

bipolar disorderHTR2A–1354C/Tmeta-analysisschizophrenia
Type
Review article
Information
Acta Neuropsychiatrica , Volume 25 , Issue 6 , December 2013 , pp. 311 - 319
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2013 

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Footnotes

Lian Gu, Jinjing Tan and Li Su are co-first authors for this article.

Lian Gu and Yuwang Qin are co-corresponding authors for this article.

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