Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-09T22:56:41.706Z Has data issue: false hasContentIssue false
  • English
  • Français

Lithium als adjuvans bij een therapie-resistente depressie: een casus

Published online by Cambridge University Press:  18 September 2015

J. Dirkx
Get access Rights & Permissions [Opens in a new window]

Summary

Lithium was added to imipramine in case of a 55-year old depressed woman who didn't respond to imipramine alone. There was a clear improvement within a few days on 900 mg lithium carbonate a day (lithium plasmalevel 0.9 mmol/l). However when after two weeks the lithium dose was reduced to 600 mg a day (lithium plasmalevel 0.5 mmol/l), an almost immediate relapse followed. On resuming lithium in the old dose the depression disappeared again. After four weeks the second attempt at reducing and eventually stopping the lithium appeared to be successful. Half a year after cessation of lithium imipramine was also stopped. More than a year afterwards there hasn't been a depression again.

In this case, after a fast potentiation of imipramine by lithium, a relapse followed when the lithium dose was reduced. It seems to be that even a high and successful starting dose of lithium needs to be continued for some time in order to prevent a relapse.

Keywords

lithiumantidepressantaugmentationdoselength of therapylithiumantidepressivaadjuvansdoseringtherapieduur
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 3 , Issue 2 , June 1991 , pp. 30 - 33
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literatuur

1.De Montigny, C, Grunberg, F, Mayer, A. Deschenes, JP. Lithium induces rapid relief of depression in tricyclic drug non-responders. Br J Psychiat 1981; 138: 252–6.CrossRefGoogle ScholarPubMed
2.De Montigny, C, Cournoyer, G, Morissette, R. Langlois, R. Caille, G. Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression. Arch gen Psychiat 1983; 40: 1327–34.CrossRefGoogle ScholarPubMed
3.Heninger, GR, Charney, DS. Sternberg, DE. Lithium carbonate augmentation of antidepressant treatment. Arch gen Psychiat 1983;40: 1335–42.CrossRefGoogle ScholarPubMed
4.De Montigny, C, Elie, R, Caille, G. Rapid response to the addition of lithium in Inprindole-resistant unipolar depression: A pilot study. Am J Psychiat 1985; 142: 220–3.Google Scholar
5.Hooge, de JK. Lithium in combinatie met antidepressiva als behandeling van therapie-resistente depressies bij bejaarden. Tijdschr Psychiat 1988; 30: 365–75.Google Scholar
6.Price, LH, Charney, DS, Heninger, GR. Variability of response to lithium augmentation in refractory depression. Am J Psychiat 1986; 143: 1387–92.Google ScholarPubMed
7.Schöpf, J. Lithiumzugabe zu Thymoleptika als Behandlung therapieresistenter Depressionen. Nervenarzt 1989; 60: 200–5.Google Scholar
8.Kushnir, SL. Lithium-antidepressant combinations in the treatment of depressed, physically ill geriatric patients. Am J Psychiat 1986; 143: 378–9.Google ScholarPubMed
9. Diagnostic and Statistical Manual of Mental Disorders (Third Edition Revised). DSM-III-R. Washington. DC, American Psychiatric Association, 1987.Google Scholar
10.Bech, P, Kastrup, M, Rafaelsen, OJ. Mini-compendium van beoordelingsschalen in de psychiatric BrusselVUB-Press. 1989.Google Scholar
11.Birkhimer, LJ. Alderman, M, Schmitt, CE. Ednie, KJ. Combined trazodonlithium therapy for refractory depression. Am J Psychiat 1983; 140: 1382–3.Google ScholarPubMed
12.Pope, HG, McElroy, SL, Nixon, RA. Possible synergism between fluoxetine and lithium in refractory depression. Am J Psychiat 1988; 145: 1293–4.Google ScholarPubMed
13.Price, LH, Conwell, Y, Nelson, JC. Lithium augmentation of combined neuroleptic-tricyclic treatment in delusional depression. Am J Psychiat 1983: 140: 318–22.Google ScholarPubMed
14.Schrader, GD. Levien, HEM. Response to sequential administration of clomipramine and lithium carbonate in treatment resistant depression. Br J Psychiat 1985: 147: 573–5.CrossRefGoogle ScholarPubMed
15.Nelson, CJ, Byck, R. Rapid response to lithium in phenelzine nonresponders. Br J Psychiat 1982; 141: 85–6.CrossRefGoogle ScholarPubMed
16.Kramlinger, KG. Post, RM. The addition of lithium to carbamazepine. Antidepressant efficacy in treatment-resistant depression. Arch gen Psychiat 1989; 46: 794–800.Google ScholarPubMed
17.Van Praag, HM. Psychofarmaca. Assen/Maastricht: Van Gorcum 1988.Google Scholar
18.Nolen, WA. Behandeling van depressie. Strategieën bij de keuze van antidepressiva en andere biologische behandelmethoden. Assen/Maastricht: Van Gorcum 1986.Google Scholar
19.Nierenberg, M, Price, LH. Charney, DS. Heninger, GR. After lithium augmentation: a retrospective follow-up of patients with antide-pressant-refractory depression. J aff Dis 1990; 18: 167–75.CrossRefGoogle ScholarPubMed