Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-30T15:36:11.299Z Has data issue: false hasContentIssue false
  • English
  • Français

Lack of association between BDNF Val66Met gene polymorphism and late-onset depression in a Chinese Han population

Published online by Cambridge University Press:  24 June 2014

Jiayong You ,
Yonggui Yuan ,
Yanyan Shi ,
Zhijun Zhang ,
Xiangrong Zhang  and
Hailin Li
Jiayong You
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China
Yonggui Yuan*
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China School of Clinical Medicine, Southeast University, Nanjing, 210009, China
Yanyan Shi
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China
Zhijun Zhang*
Affiliation:
Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, 210009, China
Xiangrong Zhang
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China
Hailin Li
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China
*
Yonggui Yuan, Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Guangzhou Road 264#, Nanjing 210029, PR China. Tel: +86 25 83700011-6209; Fax: +86 25 8370 9025; E-mail: [email protected]
Zhijun Zhang, Department of Neurology, Affiliated ZhongDa Hospital of Southeast University. DingJiaQiao Road 87#, Nanjing 210009, PR China. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been suggested to be associated with major depressive disorder (MDD). There were a few reports of the relationship between the variant and late-onset depression (LOD) in Chinese Han population.

Objective:

To investigate the relationship among BDNF Val66Met gene variants, BDNF plasma level and LOD.

Methods:

Chinese Han patients with LOD (n = 99) and control subjects (n = 110) were assessed for BDNF Val66Met gene polymorphism. BDNF plasma level was tested only in LOD.

Results:

There were no significant differences in genotypes and allele frequencies between cases and controls (p = 0.744 and p = 0.845, respectively). Plasma BDNF level also did not show significant differences in three genotypes in LOD (p = 0.860).

Conclusion:

The Val66Met polymorphism in BDNF gene may not confer susceptibility to LOD in Chinese Han population.

Keywords

brain-derived neurotrophic factor (BDNF)genelate-onset depression
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 21 , Issue 4 , August 2009 , pp. 186 - 190
Copyright
Copyright © 2009 John Wiley & Sons A/S

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Duman, RS, Monteggia, LM.A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006;59:1116–1127. CrossRefGoogle ScholarPubMed
Dwivedi, Y, Rizavi, HS, Conley, RRet al. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003;60:804–815. CrossRefGoogle ScholarPubMed
Shimizu, E, Hashimoto, K, Okamura, Net al. Alterations of serum levels of brain derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54:70–75. CrossRefGoogle ScholarPubMed
Karege, F, Bondolfi, G, Gervasoni, Net al. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005;57:1068–1072. CrossRefGoogle ScholarPubMed
Karege, F, Perret, G, Bondolfi, Get al. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002;109:143–148. CrossRefGoogle ScholarPubMed
Egan, MF, Kojima, M, Callicott, JHet al. The BDNF val66met polymorphism affects activity dependent secretion of BDNF and human memory and hippocampal function. Cell 2003;112:257–269. CrossRefGoogle ScholarPubMed
Ribeiro, L, Busnello, JV, Cantor, RMet al. The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Neuroreport 2007;18:1291–1293. CrossRefGoogle ScholarPubMed
Tsai, SJ, Cheng, CY, Yu, YWet al. Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response. Am J Med Genet B Neuropsychiatr Genet 2003;123:19–22. CrossRefGoogle Scholar
Hong, CJ, Huo, SJ, Yen, FCet al. Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 2003;48:186–189. CrossRefGoogle ScholarPubMed
Schumacher, J, Jamra, RA, Becker, Tet al. Evidence for a relationship between genetic variants at the brainderived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 2005;58:307–314. CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edn. Washington, DC: American Psychiatric Press, 1994. Google Scholar
Hamilton, M.A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62. CrossRefGoogle ScholarPubMed
Hamilton, M.The assessment of anxiety states by rating. Br J Med Psychol 1959;32:50–55. CrossRefGoogle ScholarPubMed
Huang, TL, Lee, CT, Liu, YL.Serum brain-derived neurotrophic factor levels in patients with major depression: effects of antidepressants. J Psychiatr Res 2008;42:521–525. CrossRefGoogle ScholarPubMed
Piccinni, A, Marazziti, D, Catena, Met al. Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments. J Affect Disord 2008;105:279–283. CrossRefGoogle ScholarPubMed
Gervasoni, N, Aubry, JM, Bondolfi, Get al. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode. Neuropsychobiology 2005;51:234–238. CrossRefGoogle ScholarPubMed
Yu, H, Zhang, ZJ, Shi, YMet al. The decreased serum BDNF concentrations of amnestic mild cognitive impairment is unrelated to the Val66Met polymorphism in Chinese Han. J Clin Psychiatry 2008;69:1104–1111. CrossRefGoogle Scholar
Pan, W, Banks, WA, Fasold, MBet al. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998;37:1553–1561. CrossRefGoogle ScholarPubMed
Lee, HY, Kim, YK.Plasma brain-derived neurotrophic factor as a peripheral marker for the action mechanism of antidepressants. Neuropsychobiology 2008;57:194–199. CrossRefGoogle ScholarPubMed
Kaija, H, Sami, A, Martti, Het al. Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder. Eur Arch Psychiatry Clin Neurosci 2007;257:31–35. CrossRefGoogle Scholar
Shimizu, E, Hashimoto, K, Iyo, M.Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am J Med Genet B Neuropsychiatr Genet 2004;126B:122–123. CrossRefGoogle ScholarPubMed
Hwang, JP, Tsai, SJ, Hong, CJet al. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 2006;27:1834–1837. CrossRefGoogle ScholarPubMed
Szeszko, PR, Lipsky, R, Mentschel, Cet al. Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry 2005;10:631–636. CrossRefGoogle ScholarPubMed
Hickie, I, Naismith, S, Ward, PBet al. Reduced hippocampal volumes and memory loss in patients with early and late-onset depression. Br J Psychiatry 2005;186:197–202. CrossRefGoogle ScholarPubMed
Shimizu, E, Hashimoto, K, Koizumi, Het al. No association of the brain-derived neurotrophic factor (BDNF) gene polymorphisms with panic disorder. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:708–712. CrossRefGoogle ScholarPubMed