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Accepted manuscript

Investigation of the Relationship of Sleep Disorder Occurring in Fibromyalgia with Central Nervous System and Pineal Gland Volume

Published online by Cambridge University Press:  11 November 2024

İlyas UÇAR Open the ORCID record for İlyas UÇAR [Opens in a new window] ,
Fatih ÇİÇEK Open the ORCID record for Fatih ÇİÇEK [Opens in a new window] ,
Turgut SEBER Open the ORCID record for Turgut SEBER [Opens in a new window] ,
Fatma Gül ÜLKÜ DEMİR Open the ORCID record for Fatma Gül ÜLKÜ DEMİR [Opens in a new window]  and
Ali Türker ÇİFTÇİ Open the ORCID record for Ali Türker ÇİFTÇİ [Opens in a new window]
İlyas UÇAR*
Affiliation:
Department of Anatomy, Faculty of Medicine, Erciyes University, TR-38030 Kayseri, Türkiye.
Fatih ÇİÇEK
Affiliation:
Department of Anatomy, Faculty of Medicine, Institute of Health Sciences, Erciyes University, TR-38030 Kayseri, Türkiye, E-mail: [email protected].
Turgut SEBER
Affiliation:
Department of Radiology, Kayseri City Education and Research Hospital, E-mail: [email protected]
Fatma Gül ÜLKÜ DEMİR
Affiliation:
Department of Physical Medicine and Rehabilitation, Kayseri City Hospital, Kayseri, Turkey, E-mail: [email protected]
Ali Türker ÇİFTÇİ
Affiliation:
Department of Biostatistics and Medical Information, Faculty of Medicine, Niğde Ömer Halisdemir University, TR-51240 Niğde, Türkiye, E-mail: [email protected].
*
Corresponding author: İlyas UÇAR, Adress: Erciyes University Faculty of Medicine, 38030, Melikgazi/KAYSERİ, E-mail: [email protected] Work Telephone Numbers: +90 (352) 437 49 10 Fax: +90 (352) 437 52 85
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Abstract

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Objective:

Mechanisms of sleep disorders in fibromyalgia (FM) patients, such as insomnia, early morning awakenings and poor quality sleep, have not yet been proven and no consistent and effective treatment is yet available. The aim of this study was to investigate the pineal gland volume and the relationship between total fiber count, total fiber volume and total fiber length of the spinoreticular tract involved in regulation of sleep and wakefulness in terms of the mechanism of sleep disturbance.

Methods:

This study included only female cases, 31 with fibromyalgia and 31 controls. Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Tractography of targeted pathway from brain diffusion MR images was calculated in DSI Studio program and the volume of the pineal gland was calculated in ITK-SNAP program.

Results:

The mean volume of the pineal gland was higher in control group (218.84±64.45 mm3) than in fibromyalgia group (174.77±48.65 mm3), which was statistically significant (p=0.004). However, there was no statistically significant difference between two groups in total spinoreticular tract (TSRT), total volume (TSRTV), TSRT FA, TSRT MD, TSRT AD and TSRT RD of spinoreticular tract, which is involved in the regulation of sleep and wakefulness (p>0.05).

Conclusion:

In conclusion, it is thought that the endocrine system may be more related to sleep disturbance in individuals with FM than central nervous system. Therefore, we believe that it may be more appropriate to work on the endocrine system rather than neural system in the treatment of sleep disturbance in patients with FM.

Keywords

FibromiyalgiaSleepTractographyPineal glandSpinoreticular tract
Type
Original Article
Information
Acta Neuropsychiatrica , Accepted manuscript , pp. 1 - 17
Copyright
© Scandinavian College of Neuropsychopharmacology 2024