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HPLC analysis and pharmacokinetics of the enantiomers of R,S-oxazepam and R,S-temazepam with their corresponding glucuronide conjugates in urine and plasma of man

Published online by Cambridge University Press:  18 September 2015

T.B. Vree ,
A.M. Baars  and
E.W. Wuis
T.B. Vree*
Affiliation:
Afdeling Klinische Farmacie en Anesthesiologie, Academisch Ziekenhuis Nijmegen Sint Radboud, Geert Grooteplein Zuid 8, 6525 GA Nijmegen Anesthesiologie, Academisch Ziekenhuis Nijmegen Sint Radboud, Geert Grooteplein Zuid 8, 6525 GA Nijmegen
A.M. Baars
Affiliation:
Afdeling Klinische Farmacie en Anesthesiologie, Academisch Ziekenhuis Nijmegen Sint Radboud, Geert Grooteplein Zuid 8, 6525 GA Nijmegen
E.W. Wuis
Affiliation:
Afdeling Klinische Farmacie en Anesthesiologie, Academisch Ziekenhuis Nijmegen Sint Radboud, Geert Grooteplein Zuid 8, 6525 GA Nijmegen
*
Afdeling Klinische Farmacie, Academisch Ziekenhuis Nijmegen Sint Radboud Ziekenhuis, Geert Grooteplein Zuid 8, 6525 GA Nijmegen
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Summary

R,S-Oxazepam and R,S-temazepam can be separated in their enantiomers by means of a chiral AGP column. The corresponding R- and S-glucuronide conjugates can be separated on a normal reversed-phase C18 column. Man conjugates the S-enantiomer of oxazepam and temazepam both better than the R-enantiomer. The urinary recovery of the glucuronides following either R,S,-oxazepam or R,S-temazepam almost amounts to 100% of the dose administered.

Keywords

HPLC analysisoxazepamtemazepamenantiomersglucuronidespharmacokineticsHPLC analyseoxazepamtemazepamenantiomerenglucuronidenfarmacokinetiek
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 2 , Issue 4 , December 1990 , pp. 95 - 100
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1990

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