Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-24T06:40:25.908Z Has data issue: false hasContentIssue false
  • English
  • Français

Functional polymorphism of the myeloperoxidase gene (G-463A) in depressive patients

Published online by Cambridge University Press:  24 June 2014

Piotr Gałecki ,
Antoni Florkowski ,
Kinga Bobińska ,
Janusz Śmigielski ,
Małgorzata Bieńkiewicz  and
Janusz Szemraj
Piotr Gałecki*
Affiliation:
Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
Antoni Florkowski
Affiliation:
Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
Kinga Bobińska
Affiliation:
Department of Adult Psychiatry, Medical University of Lodz, Lodz, Poland
Janusz Śmigielski
Affiliation:
Department of Informatics and Medical Statistics, Medical University of Lodz, Lodz, Poland
Małgorzata Bieńkiewicz
Affiliation:
Department of Quality Control and Radiological Protection, Medical University of Lodz, Lodz, Poland
Janusz Szemraj
Affiliation:
Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland
*
Piotr Gałecki, Department of Adult Psychiatry, Medical University of Lodz, Aleksandrowska 159, Lodz 91-229, Poland. Tel: +48 426521289; Fax: +48 426405058; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Gałecki P, Florkowski A, Bobińska K, Śmigielski J, Bieńkiewicz M, Szemraj J. Functional polymorphism of the myeloperoxidase gene (G-463A) in depressive patients.

Objective:

Myeloperoxidase (MPO) is an enzyme involved in the production of hypochloric acid as well as other reactive oxygen species. This enzyme plays a significant role in inflammatory processes. In view of the observed associations between depression and such inflammatory processes, as well as of the reports that confirm the presence of oxidative stress in depression, this study was designed to assess the correlation, if any, between the single nucleotide polymorphism G-463A of the MPO gene and the risk of recurrent depressive disorders (DD).

Methods:

The study was carried out in a group of 149 patients with recurrent DD and 149 healthy control subjects. Genotyping was performed by PCR/restriction fragment length polymorphism.

Results:

A comparison between healthy controls and depressive patients showed a statistically significant difference in genotype distribution and allele frequency in the studied groups. Genotype distribution and allele frequency did not correlate with clinical variables of the patients.

Conclusion:

The obtained results of the study allow us to draw a cautious conclusion about the role of the analysed G-463A MPO polymorphism in recurrent DD development, which, however, requires eventual confirmation in further studies.

Keywords

depressiongene polymorphismmyeloperoxidase
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 22 , Issue 5 , October 2010 , pp. 218 - 222
Copyright
Copyright © 2010 John Wiley & Sons A/S

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Raison, CL, Capuron, L, Miller, AH.Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006;27:24–31. CrossRefGoogle ScholarPubMed
Maes, M.Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 1995;19:11–38. CrossRefGoogle ScholarPubMed
Leonard, BE.Inflammation, depression and dementia: are they connected?. Neurochem Res 2007;32:1749–1756. CrossRefGoogle ScholarPubMed
Nauseef, WM.Contribution of myeloperoxidase to proinflammatory events: more than an antimicrobial system. Int J Hematol 2001;74:125–133. CrossRefGoogle ScholarPubMed
Yap, YW, Whiteman, M, Cheung, NS.Chlorinative stress: an under appreciated mediator of neurodegeneration? Cell Signal 2007;19:219–228. CrossRefGoogle ScholarPubMed
Green, PS, Mendez, AJ, Jacob, JSet al. Neuronal expression of myeloperoxidase is increased in Alzheimer's disease. J Neurochem 2004;90:724–733. CrossRefGoogle ScholarPubMed
Hansson, M, Olsson, I, Nauseef, WM.Biosynthesis, processing, and sorting of human myeloperoxidase. Arch Biochem Biophys 2006;445:214–224. CrossRefGoogle ScholarPubMed
Malle, E, Furtmüller, PG, Sattler, W, Obinger, C.Myeloperoxidase: a target for new drug development? Br J Pharmacol 2007;152:838–854. CrossRefGoogle ScholarPubMed
Spickett, CM, Jerlich, A, Panasenko, OMet al. The reactions of hypochlorous acid, the reactive oxygen species produced by myeloperoxidase, with lipids. Acta Biochim Pol 2000;47:889–899. CrossRefGoogle ScholarPubMed
Khanzode, SD, Dakhale, GN, Khanzode, SS, Saoji, A, Palasodkar, R.Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors. Redox Rep 2003;8:365–370. CrossRefGoogle ScholarPubMed
Lucca, G, Comim, CM, Valvassori, SSet al. Effects of chronic mild stress on the oxidative parameters in the rat brain. Neurochem Int 2009;54:358–362. CrossRefGoogle ScholarPubMed
Yanik, M, Erel, O, Kati, M.The relationship between potency of oxidative stress and severity of depression. Acta Neuropsychiatry 2004;16:200–203. CrossRefGoogle ScholarPubMed
Monkul, ES, Malhi, GS, Soares, JC.Mood disorders – review of structural MRI studies. Acta Neuropsychiatry 2003;15:368–380. CrossRefGoogle Scholar
Bachis, A, Cruz, MI, Nosheny, RL, Mocchetti, I.Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex. Neurosci Lett 2008;442:104–108. CrossRefGoogle ScholarPubMed
Lefkowitz, DL, Lefkowitz, SS.Microglia and myeloperoxidase: a deadly partnership in neurodegenerative disease. Free Radic Biol Med 2008;45:726–731. CrossRefGoogle ScholarPubMed
Ekdahl, CT, Claasen, JH, Bonde, S, Kokaia, Z, Lindvall, O.Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA 2003;100:13632–13637. CrossRefGoogle ScholarPubMed
Xu, H, Chen, Z, He, Jet al. Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus. Hippocampus 2006;16:551–559. CrossRefGoogle ScholarPubMed
Leonard, BE.The immune system, depression and the action of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:767–780. CrossRefGoogle ScholarPubMed
Maes, M, Smith, RS.Fatty acid, cytokines, and major depression. Biol Psychiatry 1998;43:313–314. Google ScholarPubMed
Peet, M, Murphy, B, Shay, J, Horrobin, D.Depletion of omega-3 fatty acids levels in red blood cells membranes of depressive patients. Biol Psychiatry 1998;43:315–319. CrossRefGoogle ScholarPubMed
Tomàs, C, Cañellas, F, Rodríguez, Vet al. Genetic linkage study for bipolar disorders on chromosomes 17 and 18 in families with a high expression of mental illness from the Balearic Islands. Psychiatr Genet 2006;16:145–151. CrossRefGoogle ScholarPubMed
Piedrafita, FJ, Molander, RB, Vansant, G, Orlova, EA, Pfahl, M, Reynolds, WF.An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element. J Biol Chem 1996;271: 14412–14420. CrossRefGoogle ScholarPubMed
Hoy, A, Trégouët, D, Leininger-Muller, Bet al. Serum myeloperoxidase concentration in a healthy population: biological variations, familial resemblance and new genetic polymorphisms. Eur J Hum Genet 2001;9:780–786. CrossRefGoogle Scholar
Hoy, A, Leininger-Muller, B, Kutter, D, Siest, G, Visvikis, S.Growing significance of myeloperoxidase in non-infectious diseases. Clin Chem Lab Med 2002;40:2–8. CrossRefGoogle ScholarPubMed
Vaccarino, V, Brennan, ML, Miller, AHet al. Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Biol Psychiatry 2008;64:476–483. CrossRefGoogle Scholar
ICD 10. The international statistical classification of diseases and related health problems, 10th revision. Geneva: WHO, 1992. Google Scholar
Bland, JM, Altman, DG.Statistics notes: the odds ratio. BMJ 2000;320:1468. Google ScholarPubMed
Shi, M, Hu, J, Dong, Xet al. Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese. Acta Neuropsychiatry 2008;20:139–144. CrossRefGoogle ScholarPubMed
Lee, HY, Kang, RH, Han, SWet al. Association of glucocorticoid receptor polymorphisms with the susceptibility to major depressive disorder and treatment responses in Korean depressive patients. Acta Neuropsychiatry 2009;21: 11–17. CrossRefGoogle ScholarPubMed
Hallingbäck, HR, Gabdoulline, RR, Wade, RC.Comparison of the binding and reactivity of plant and mammalian peroxidases to indole derivatives by computational docking. Biochemistry 2006;45:2940–2950. CrossRefGoogle Scholar
Crawford, FC, Freeman, MJ, Schinka, JAet al. Association between Alzheimer's disease and a functional polymorphism in the myeloperoxidase gene. Exp Neurol 2001;167:456–459. CrossRefGoogle Scholar
Reynolds, WF, Rhees, J, Maciejewski, Det al. Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease. Exp Neurol 1999;155:31–41. CrossRefGoogle ScholarPubMed
Zappia, M, Manna, I, Serra, Pet al. Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms. Arch Neurol 2004;61:341–344. CrossRefGoogle ScholarPubMed
Usui, C, Shibata, N, Ohnuma, Tet al. No genetic association between the myeloperoxidase gene -463 polymorphism and estrogen receptor-alpha gene polymorphisms and Japanese sporadic Alzheimer's disease. Dement Geriatr Cogn Disord 2006;21:296–299. CrossRefGoogle ScholarPubMed
Combarros, O, Infante, J, Llorca, J, Peña, N, Fernández-Viadero, C, Berciano, J.The myeloperoxidase gene in Alzheimer's disease: a case-control study and meta-analysis. Neurosci Lett 2002;326:33–36. CrossRefGoogle ScholarPubMed
Gohier, B, Ferracci, L, Surguladze, SAet al. Cognitive inhibition and working memory in unipolar depression. J Affect Disord 2009;116:100–105. CrossRefGoogle ScholarPubMed
Pope, SK, Kritchevsky, SB, Ambrosone, Cet al. Myeloperoxidase polymorphism and cognitive decline in older adults in the health, aging, and body composition study. Am J Epidemiol 2006;163:1084–1090. CrossRefGoogle ScholarPubMed
Manna, I, Valentino, P, La Russa, Aet al. Genetic variation in the myeloperoxidase gene and cognitive impairment in multiple sclerosis. J Negat Results Biomed 2006;5:3. CrossRefGoogle ScholarPubMed
Marrie, R, Horwitz, R, Cutter, G, Tyry, T, Campagnolo, D, Vollmer, T.The burden of mental comorbidity in multiple sclerosis: frequent, underdiagnosed, and undertreated. Mult Scler 2009;15:385–392. CrossRefGoogle ScholarPubMed
Kantarci, OH, Atkinson, EJ, Hebrink, DD, McMurray, CT, Weinshenker, BG.Association of a myeloperoxidase promoter polymorphism with multiple sclerosis. J Neuroimmunol 2000;105:189–194. CrossRefGoogle ScholarPubMed
Nagra, RM, Becher, B, Tourtellotte, WWet al. Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis. J Neuroimmunol 1997;78: 97–107. CrossRefGoogle ScholarPubMed
Nikpoor, B, Turecki, G, Fournier, C, Théroux, P, Rouleau, GA.A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians. Am Heart J 2001;142:336–339. CrossRefGoogle ScholarPubMed
Wulsin, LR, Singal, BM.Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review. Psychosom Med 2003;65:201–210. CrossRefGoogle ScholarPubMed
McCaffery, JM, Frasure-Smith, N, Dubé, MPet al. Common genetic vulnerability to depressive symptoms and coronary artery disease: a review and development of candidate genes related to inflammation and serotonin. Psychosom Med 2006;68:187–200. CrossRefGoogle ScholarPubMed
Carr, AC, McCall, MR, Frei, B.Oxidation of LDL by myeloperoxidase and reactive nitrogen species: reaction pathways and antioxidant protection. Arterioscler Thromb Vasc Biol 2000;20:1716–1723. CrossRefGoogle ScholarPubMed
Jun, TY, Pae, CU, Hoon-Han, Set al. Possible association between -G308A tumor necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population. Psychiatr Genet 2003;13:179–181. CrossRefGoogle ScholarPubMed
Pae, CU, Yu, HS, Kim, TSet al. Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population. Psychiatry Res 2004;127:279–281. CrossRefGoogle Scholar
Wong, ML, Dong, C, Maestre-Mesa, J, Licinio, J.Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. Mol Psychiatry 2008;13:800–812. CrossRefGoogle ScholarPubMed
Sullivan, PF.Spurious genetic associations. Biol Psychiatry 2007;61:1121–1126. CrossRefGoogle ScholarPubMed
Atzeni, F, Boiardi, L, Casali, Bet al. Lack of association of the -463 G/A myeloperoxidase promoter polymorphism with Behcet's disease in Italian patients. Rheumatology (Oxford) 2007;46:1547–1550. CrossRefGoogle ScholarPubMed
Feyler, A, Voho, A, Bouchardy, Cet al. Point: myeloperoxidase -463G–> a polymorphism and lung cancer risk. Cancer Epidemiol Biomarkers Prev 2002;11:1550–1554. Google ScholarPubMed
Osterreicher, CH, Datz, C, Stickel, Fet al. Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis. J Hepatol 2005;42:914–919. CrossRefGoogle ScholarPubMed
Rajp, A, Adu, D, Savage, CO.Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis. Clin Exp Immunol 2007;149:251–256. CrossRefGoogle ScholarPubMed