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Effect of vitamin E on cisplatin-induced memory impairment in male rats

Published online by Cambridge University Press:  15 October 2020

Masoud Hosseinzadeh ,
Amir Alizadeh ,
Parnian Heydari ,
Marzieh Kafami Open the ORCID record for Marzieh Kafami [Opens in a new window] ,
Mahmoud Hosseini ,
Farimah Beheshti ,
Narges Marefati  and
Moustafa Ghanbarabadi
Masoud Hosseinzadeh
Affiliation:
Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
Amir Alizadeh
Affiliation:
Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
Parnian Heydari
Affiliation:
Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
Marzieh Kafami*
Affiliation:
Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
Mahmoud Hosseini
Affiliation:
Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Farimah Beheshti
Affiliation:
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
Narges Marefati
Affiliation:
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Moustafa Ghanbarabadi
Affiliation:
Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
*
Author for correspondence: Marzieh Kafami, E-mail: [email protected]
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Abstract

Objective:

Neurotoxicity is an adverse effect caused by cisplatin due to inflammation and oxidative stress in the central nervous system. The present study aimed to assess the effects of vitamin E injection on the learning and memory of rats with cisplatin-induced cognitive impairment.

Methods:

Male rats were administered with cisplatin (2 mg/kg/7 day; intraperitoneally [i i.p.]) and/or vitamin E (200 mg/kg/7 day; i.p.) for 1 week, and the control group received saline solution. Spatial memory was evaluated using Morris water maze (MWM). In addition, the hippocampal concentrations of malondialdehyde (MDA), thiol, and superoxide dismutase (SOD) were measured using biochemical methods.

Results:

According to the findings, cisplatin significantly increased the escape latency, while decreasing the time spent and travelled pathway in the target quadrant on the final trial day compared to the control group. Furthermore, pre-treatment with vitamin E significantly reversed all the results in the spatial memory test. The biochemical data indicated that vitamin E could decrease MDA activity and increase thiol and SOD activity compared to the control group.

Conclusion:

According to the results, vitamin E could improve cisplatin-induced memory impairment possibly through affecting the hippocampal oxidative status.

Keywords

vitamin Ecisplatinmemorymalondialdehydesuperoxide dismutase
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 33 , Issue 1 , February 2021 , pp. 43 - 48
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Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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References

Abou-Elghait, A, El-Gamal, DA, Abdel-Sameea, AR, and Mohamed, AA (2010) Effect of cisplatin on the cerebellar cortex and spinal cord of adult male albino rat and the possible role of vitamin E: light and electron microscopic study. Journal of Histology & Histopathology 33, 202–212.Google Scholar
Ahles, TA and Saykin, AJ (2007) Candidate mechanisms for chemotherapy-induced cognitive changes. Nature Reviews Cancer 7, 192–201.CrossRefGoogle ScholarPubMed
Ajith, TA, Abhishek, G, Roshny, D and Sudheesh, NP (2009) Co-supplementation of single and multi doses of vitamins C and E ameliorates cisplatin-induced acute renal failure in mice. Experimental and Toxicologic Pathology 61, 565–571.CrossRefGoogle Scholar
Ajith, TA, Usha, S, and Nivitha, V (2007) Ascorbic acid and α-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice: a comparative study. Clinica Chimica Acta, 375, 82–86.CrossRefGoogle ScholarPubMed
Argyriou, AA, Chroni, E, Koutras, A, Iconomou, G, Papapetropoulos, S, Polychronopoulos, P and Kalofonos, HP (2006) A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results. Support Care Cancer 14, 1134–1140.CrossRefGoogle ScholarPubMed
Baghcheghi, Y, Beheshti, F, Shafei, MN, Salmani, H, Sadeghnia, HR, Soukhtanloo, M, Anaeigoudari, A and Hosseini, M (2018) The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats. Metabolic Brain Disease 33, 713–724.CrossRefGoogle ScholarPubMed
Bost, F, Sahra, IB, Marchand-Brustel, YL and Tanti, J-F (2012) Metformin and cancer therapy. Current Opinion in Oncology 24, 103–108.CrossRefGoogle ScholarPubMed
Bove, L, Picardo, M, Maresca, V, Jandolo, B and Pace, A. (2001) A pilot study on the relation between cisplatin neuropathy and vitamin E. Journal of Experimental and Clinical Cancer Research 20, 277–280.Google ScholarPubMed
Catalgol, B and Nesrin, KO (2012) Protective effects of vitamin E against hypercholesterolemia-induced age-related diseases. Genes & Nutrition 7, 91.CrossRefGoogle ScholarPubMed
Chen, Y, Jungsuwadee, P, Vore, M, Allan Butterfield, D and St Clair, DK (2007) Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues. Molecular Interventions 7, 147.CrossRefGoogle ScholarPubMed
Chun, J, Lee, J, Ye, L, Exler, J and Eitenmiller, RR (2006) Tocopherol and tocotrienol contents of raw and processed fruits and vegetables in the United States diet. Journal of Food Composition and Analysis 19, 196–204.CrossRefGoogle Scholar
Council National Research (2010) Guide for the Care and Use of Laboratory Animals. National Academies Press.Google Scholar
da Silva Machado, C, Mendonça, LM, de Paula Venancio, V, Bianchi, MLP and Antunes, LMG (2013) Coenzyme Q10 protects Pc12 cells from cisplatin-induced DNA damage and neurotoxicity. Neurotoxicology 36, 10–16.CrossRefGoogle ScholarPubMed
Dietrich, J, Han, R, Yang, Y, Mayer-Pröschel, M and Noble, M (2006) CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. Journal of Biology 5, 22.CrossRefGoogle ScholarPubMed
Green, RM, Hodges, NJ, Chipman, JK, O’Donovan, MR and Graham, M (2008) Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls. Mutagenesis 23, 457–463.CrossRefGoogle ScholarPubMed
Halliwell, B and Gutteridge, JMC (2015) Free radicals in biology and medicine (Oxford University Press, USA). Sem Hop 58(45), 2670–2675.Google Scholar
Hassan, I, Chibber, S, Khan, AA and Naseem, I (2013) Cisplatin-induced neurotoxicity in vivo can be alleviated by riboflavin under photoillumination. Cancer Biotherapy and Radiopharmaceuticals 28, 160–168.CrossRefGoogle ScholarPubMed
Hinduja, S, Kraus, KS, Manohar, S and Salvi, RJ (2015) d-Methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotoxicity Research 27, 199–204.CrossRefGoogle ScholarPubMed
Jain, SK and Palmer, M (1997) The effect of oxygen radicals metabolites and vitamin E on glycosylation of proteins. Free Radical Biology and Medicine 22, 593–596.CrossRefGoogle ScholarPubMed
Jang, J-H and Young-Joon, S (2002) β-Amyloid induces oxidative DNA damage and cell death through activation of c-Jun N terminal kinase. Annals of the New York Academy of Sciences 973, 228–236.CrossRefGoogle ScholarPubMed
Jilanchi, S, Nematbakhsh, M, Bahadorani, M, Talebi, A, Eshraghi-Jazi, F, Mansouri, A and Ashrafi, F (2013) Vitamin E is a nephroprotectant agent in male but not in female in a model of Cisplatin-induced nephrotoxicity. ISRN Nephrology, 2013.CrossRefGoogle ScholarPubMed
John, T, Lomeli, N and Bota, DA (2017) Systemic cisplatin exposure during infancy and adolescence causes impaired cognitive function in adulthood. Behavioural Brain Research 319, 200–206.CrossRefGoogle ScholarPubMed
Kaasa, S, Olsnes, BT, Thorud, E and Høst, H (1988) Reduced short-term neuropsychological performance in patients with nonsmall-cell lung cancer treated with cisplatin and etoposide1.’ Antibiotics and Chemotherapy 41, 226–231.CrossRefGoogle Scholar
Kiasalari, Z, Khalili, M, Shafiee, S and Roghani, M (2016) The effect of Vitamin E on learning and memory deficits in intrahippocampal kainate-induced temporal lobe epilepsy in rats. Indian Journal of Pharmacology 48, 11.Google ScholarPubMed
Madesh, M and Balasubramanian, KA (1998) Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide. Indian Journal of Biochemistry and Biophysics (IJBB) 35, 184–188.Google ScholarPubMed
Manohar, S, Jamesdaniel, S and Salvi, R (2014) Cisplatin inhibits hippocampal cell proliferation and alters the expression of apoptotic genes. Neurotoxicity Research 25, 369–380.CrossRefGoogle ScholarPubMed
Mejia, JAA (2020) Evaluation of the cytoprotective effects of isolated compounds of Copaifera langsdorffii Desf against cytotoxicity induced by exposure to methylmercury and lead. Natural Product Research 34(17), 2528–2532.Google Scholar
Mendonça, LM, da Silva Machado, C, Teixeira, CCC, de Freitas, LAP, de Lourdes Pires Bianchi, M and Antunes, LMG (2013) Curcumin reduces cisplatin-induced neurotoxicity in NGF-differentiated PC12 cells. Neurotoxicology 34, 205–211.CrossRefGoogle ScholarPubMed
Nakagawa, H, Fujita, T, Kubo, S, Tokiyoshi, K, Yamada, M, Kanayama, T, Hagiwara, Y, Nakanomyo, H and Hiraoka, M (1996) Difference in CDDP penetration into CSF between selective intraarterial chemotherapy in patients with malignant glioma and intravenous or intracarotid administration in patients with metastatic brain tumor. Cancer Chemotherapy and Pharmacology 37, 317–126.CrossRefGoogle ScholarPubMed
Nicolson, GL and Ash, ME (2014) Lipid replacement therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function. Biochimica et Biophysica Acta 1838, 1657–1679.CrossRefGoogle ScholarPubMed
O’Farrell, E, MacKenzie, J and Collins, B (2013) Clearing the air: a review of our current understanding of “chemo fog”. Current Oncology Reports 15, 260–269.CrossRefGoogle ScholarPubMed
Oz, M, Atalik, KEN, Yerlikaya, FH and Demir, EA (2015) Curcumin alleviates cisplatin-induced learning and memory impairments. Neurobiology of Learning and Memory 123, 43–49.CrossRefGoogle ScholarPubMed
Park, SA, Choi, KS, Bang, JH, Huh, K and Kim, SU (2000) Cisplatin-induced apoptotic cell death in mouse hybrid neurons is blocked by antioxidants through suppression of cisplatin-mediated accumulation of p53 but not of Fas/Fas ligand. Journal of Neurochemistry 75, 946–953.CrossRefGoogle Scholar
Pourganji, M, Hosseini, M, Soukhtanloo, M, Zabihi, H and Al-reza Hadjzadeh, M (2014) Protective role of endogenous ovarian hormones against learning and memory impairments and brain tissues oxidative damage induced by lipopolysaccharide. Iranian Red Crescent Medical Journal 16(3), e13954.CrossRefGoogle ScholarPubMed
Radhi, M, Fulbright, JM, Ginn, KF and Guest, EM (2015) Childhood cancer for the primary care physician. Primary Care: Primary Care 42, 43–55.CrossRefGoogle ScholarPubMed
Sakat, MS, Kilic, K, Akdemir, FNE, Yildirim, S, Eser, G and Kiziltunc, A (2018) The effectiveness of eugenol against cisplatin-induced ototoxicity. Brazilian Journal of Otorhinolaryngology 85(6), 766–773.CrossRefGoogle ScholarPubMed
Schneider, C (2009) An update on products and mechanisms of lipid peroxidation. Molecular Nutrition & Food Research 53, 315–321.CrossRefGoogle ScholarPubMed
Sen, S, De, B, Devanna, N and Chakraborty, R (2013) Cisplatin-induced nephrotoxicity in mice: protective role of Leea asiatica leaves. Renal Failure 35(10), 1412–1417.CrossRefGoogle ScholarPubMed
Simó, M, Rifà-Ros, X, Rodriguez-Fornells, A and Bruna, J (2013) Chemobrain: a systematic review of structural and functional neuroimaging studies. Neuroscience & Biobehavioral Reviews 37, 1311–1321.CrossRefGoogle ScholarPubMed
Snyder, JS, Hong, NS, McDonald, RJ and Wojtowicz, JM (2005) A role for adult neurogenesis in spatial long-term memory. Neuroscience, 130, 843–852.CrossRefGoogle ScholarPubMed
Song, T-Y, Chen, C-L, Liao, J-W, Ou, H-C and Tsai, M-S (2010) Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo. Food and Chemical Toxicology 48, 3492–3499.CrossRefGoogle ScholarPubMed
Sponne, I, Fifre, A, Drouet, B, Klein, C, Koziel, V, Pinçon-Raymond, M, Olivier, J-L, Chambaz, J and Pillot, T (2003) Apoptotic neuronal cell death induced by the non-fibrillar amyloid-β peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation. Journal of Biological Chemistry 278, 3437–3445.CrossRefGoogle ScholarPubMed
Thomas, RG, and Gebhardt, SE (2006) Nuts and seeds as sources of alpha and gamma tocopherols. USDA-ARS Nutrient Data Laboratory. (USDA-abstract). http://www.ars.usda.gov/SP2UserFiles/Place/12354500/Articles/AICR06NutSeed.pdf Google Scholar
Troy, L, McFarland, K, Littman-Power, S, Kelly, BJ, Walpole, ET, Wyld, D and Thomson, D (2000) Cisplatin-based therapy: a neurological and neuropsychological review. Psychooncology 9, 29–39.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Tucker, JM and Townsend, DM (2005) Alpha-tocopherol: roles in prevention and therapy of human disease. Biomedicine & Pharmacotherapy 59, 380–387.CrossRefGoogle ScholarPubMed
Vafaee, F, Hosseini, M, Sadeghinia, HR, Al-reza Hadjzadeh, M, Soukhtanloo, M and Rahimi, M (2014) The effects of soy extract on spatial learning and memory damage induced by global ischemia in ovariectomised rats. Malaysian Journal of Medical Sciences, MJMS 21, 19.Google ScholarPubMed
Waseem, M, and Suhel, P (2013) Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin. Food and Chemical Toxicology 53, 334–342.CrossRefGoogle ScholarPubMed
Weijl, NI, Wipkink-Bakker, A, Lentjes, EGWM, Berger, HM, Cleton, FJ and Osanto, S (1998) Cisplatin combination chemotherapy induces a fall in plasma antioxidants of cancer patients. Annals of Oncology 9, 1331–1337.CrossRefGoogle ScholarPubMed
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