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The effect of stress and psychosocial variables on natural killer cells: a review

Published online by Cambridge University Press:  18 September 2015

P. Gerits  and
B. de Brabander
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Summary

In this review we discuss the results of studies about the effect of stress, depression, anxiety, social support and various psychosocial treatments on numbers and activity of Natural Killer (NK) cells. In general a suppressive effect is observed among depressive persons and persons who react to stressfull events with feelings of helplessness and anxiety. Lack of social support also seems to engender immunosuppression including NK suppression. Various forms of psychosocial care seem to be able to undo these negative consequences. However, the real clinical relevance of these findings is still a matter of dispute.

Keywords

NK cellsNK activitystressdepressionsocial supportpsychosocial treatmentNK-cellenNK-activiteitstressdepressieangstsociale ondersteuningpsychotherapeutische interven-tieprogramma's
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 4 , Issue 3 , September 1992 , pp. 63 - 68
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1992

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References

Literatuur

5.Whiteside, TL, Herberman, RB.Short analytical review: the role of natural killer cells in human disease. Clin Immunol Immunopath 1989;53:1–23.CrossRefGoogle Scholar
9.Locke, SE, Kraus, L, Leserman, J, et al.Life change stress, psychiatric symptoms, and natural killercell activity. Psychosom Med 1984;46:441–53.CrossRefGoogle Scholar
11.Jemmott, JB, Hellman, C, McClelland, DC, et al.Motivational syndromes associated with natural killer cell activity. J beh Med 1990;13:53–73.CrossRefGoogle ScholarPubMed
13.Irwin, M, Daniels, M, Smith, TL, Bloom, E, Weiner, H.Impaired natural killer cell activity during bereavement. Brain Beh Immun 1987;1:81–7.CrossRefGoogle ScholarPubMed
14.Kiecolt-Glaser, J, Fisher, L, Ogrocki, P, Stout, J, Speicher, C, Glaser, R.Marital quality, marital disruption, and immune function. Psychosom Med 1987;49:13–34.CrossRefGoogle ScholarPubMed
15.Kiecolt-Glaser, J, Garner, W, Speicher, C, Penn, GM, Holliday, J, Glaser, R.Psychosocial modifiers of immunocompetence in medical students. Psychosom Med 1984;46:7–14.CrossRefGoogle ScholarPubMed
16.Kiecolt-Glaser, J, Ricker, D, George, J, et al.Urine Cortisol levels, cellular immunocompetency, and loneliness in psychiatric inpatients. Psychosom Med 1984;46:15–23.CrossRefGoogle ScholarPubMed
17.Kiecolt-Glaser, J, Glaser, R, Strain, E, et al.Modulation of cellular immunity in medical students. J beh Med 1986;9:5–21.CrossRefGoogle ScholarPubMed
20.Moss, RB, Moss, HB, Peterson, RP.Microstress, mood and natural killer-cell activity. Psychosomatics 1989;30:279–83.CrossRefGoogle ScholarPubMed
21.McKinnon, W, Weisse, CS, Reynolds, PC, Bowles, CA, Baum, A.Chronic stress, leukocyte subpopulations, and humoral response to latent viruses. Health Psychol 1989;8:389–402.CrossRefGoogle ScholarPubMed
22.Kiecolt-Glaser, J.Glaser, R, Dyer, C, Shuttleworth, E, Ogrocki, P, Speicher, CE.Chronic stress and immunity in family caregivers of Alzheimer's disease victims. Psychosom Med 1987;49:523–35.CrossRefGoogle ScholarPubMed
23.Naliboff, BD, Benton, D, Solomon, GF, et al.Immunological changes in young and old adults during brief laboratory stress. Psychosom Med 1991;53:121–32.CrossRefGoogle Scholar
26.Irwin, M, Patterson, T, Smith, TL, et al.Reduction of immune function in life stress and depression. Biol Psychiat 1990;27:22–30.CrossRefGoogle ScholarPubMed
27.Irwin, M, Caldwell, C, Smith, TL, Brown, S, Schuckit, MA, Gillin, JC.Major depressive disorder, alcoholism, and reduced natural killer cell cytotoxicity. Arch gen Psychiat 1990;47:713–8.CrossRefGoogle ScholarPubMed
30.Nerozzi, D, Santoni, A, Bersani, G, et al.Reduced natural killer cell activity in major depression: neuroendocrine implications. Psychoneuroendocrinol 1989;14:295–301.CrossRefGoogle ScholarPubMed
33.Ironson, G, LaPerriere, A, Antoni, M, et al.Changes in immune and psychological measures as a function of anticipation and reaction to news of HIV-1 antibody status. Psychosom Med 1990;52: 247–70.CrossRefGoogle ScholarPubMed
34.Fawzy, I, Fawzy, MD, Norman, C, et al.A structured psychiatric intervention for cancer patients: changes over time in methods of coping and affective disturbance. Arch gen Psychiat 1990,47:720–5.CrossRefGoogle ScholarPubMed
35.Glaser, G, Kiecolt-Glaser, J, Speicher, GJM, Holliday, JE.Stress, loneliness, and changes in herpes virus latency. J behav Med 1985;8:249–60.CrossRefGoogle Scholar
38.Levy, S, Herberman, RB, Whiteside, T, Sanzo, K, Lee, JRN, Kirkwood, J.Perceived social support and tumor estrogen/progesterone receptor status as predictors of natural killer cell activity in breast cancer patients. Psychosom Med 1990;52:73–85.CrossRefGoogle ScholarPubMed
39.Baron, RS, Cutrona, CE, Hicklin, D, Russell, DW, Lubaroff, DM.Social support and immune function among spouses of cancer patients. J Pers soc Psychol 1990;59:344–52.CrossRefGoogle ScholarPubMed
40.Kiecolt-Glaser, J, Glaser, R Williger, et al.Psychosocial enhancement of immunocompetence in a geriatric population. Health Psychol 1985;4:25–41.CrossRefGoogle Scholar
43.Fawzy, I, Fawzy, MD, Kemeny, ME, et al.A structured psychiatric intervention for cancer patients: changes over time in immunological measures. Arch gen Psychiat 1990;47:729–35.CrossRefGoogle ScholarPubMed
45.Levy, S, Herberman, RB, Rodin, J, Seligman, M.Psychological and immunological effects of a randomized psychosocial treatment trial for colon cancer and malignant melanoma patients. In: Balner, H, van Rood, Y, eds. Publications of the Helen Dowling Institute for biopsychosocial Medicine; vol III. Lisse: Swets & Zeitlinger, 1989:75–88.Google Scholar
46.Manuck, SB, Cohen, S, Rabin, BS, et al.Individual differences in cellular immune response to stress. Psychol Sci 1991;2:111–115.CrossRefGoogle Scholar
49.Van Tits, LJH, Michel, MC, Grosse-Wilde, H, et al.Catecholamines increase lumphocyte β2-adrenergic receptors via a β2 acrenergic, spleen-dependent process. Am J Physiol 1990;258:E191–E202.Google Scholar