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Differential impairment of working memory performance in first-degree relatives of individuals with schizophrenia

Published online by Cambridge University Press:  24 June 2014

Aaron R. Kent ,
Allison M. Fox ,
Patricia T. Michie  and
Assen V. Jablensky
Aaron R. Kent*
Affiliation:
Centre for Clinical Research in Neuropsychiatry/School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Mt Claremont, Western Australia School of Psychology, The University of Western Australia, Crawley, Western Australia Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD), Darlinghurst, New South Wales, Australia
Allison M. Fox
Affiliation:
School of Psychology, The University of Western Australia, Crawley, Western Australia Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD), Darlinghurst, New South Wales, Australia
Patricia T. Michie
Affiliation:
Centre for Clinical Research in Neuropsychiatry/School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Mt Claremont, Western Australia School of Psychology, The University of Western Australia, Crawley, Western Australia Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD), Darlinghurst, New South Wales, Australia
Assen V. Jablensky
Affiliation:
Centre for Clinical Research in Neuropsychiatry/School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Mt Claremont, Western Australia
*
Aaron Kent, Centre for Clinical Research in Neuropsychiatry, Gascoyne House Graylands Hospital, Private Mail Bag no. 1, Mt Claremont 6010, Australia. Tel: + 61 (8) 9347 6429; Fax: + 61 (8) 9384 5128; E-mail: [email protected]
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Abstract

Background:

Numerous studies have reported neuropsychological impairment in schizophrenia and increasing evidence suggests that individuals with schizophrenia or schizophrenia spectrum disorders and their unaffected first-degree family members exhibit similar deficits in some neuropsychological domains. Substantial modifications to the Wechsler Memory Scale (WMS) have resulted in more sensitive and reliable indicators of various aspects of memory functioning in the WMS-III, which enables generation of auditory, visual and working memory indices.

Objective:

The aim of the present study was to examine the memory profile of individuals with schizophrenia or schizophrenia spectrum disorder (n = 19), their unaffected first-degree family members (n = 11), and healthy controls (n = 9).

Methods:

The study involved neuropsychological testing, including the immediate and working memory subtests of the WMS-III, utilizing both auditory and visual domains. Symptom assessment was performed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN), version 2.0. Two multivariate analyses of covariance (mancova) were conducted: (i) comparing patients, relatives and controls; and (ii) comparing relatives and controls only.

Results:

The first analysis indicated that the patient group obtained significantly lower index scores than both relatives and controls on all three indices. The second analysis indicated that the performance of relatives was significantly lower than controls on the working memory index, although there were no significant differences on the auditory and visual immediate index scores.

Conclusions:

The differential impairment in working memory performance in clinically asymptomatic family members suggests that the WMS-III working memory index score may be a potential phenotypic marker of schizophrenia.

Keywords

first-degree relativesschizophreniaWMS-IIIworking memory
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 16 , Issue 3 , June 2004 , pp. 149 - 153
Copyright
Copyright © 2004 Blackwell Munksgaard

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References

Barch, DM, Carter, CS. Selective attention in schizophrenia: Relationship to verbal working memory. Schizophr Res 1998;33: 53–61.CrossRefGoogle ScholarPubMed
Cannon, TD, Huttenen, MO, Lonnquist, Jet al. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 2000;67: 369–382.CrossRefGoogle ScholarPubMed
Egan, MF, Goldberg, TE, Kolachana, BSet al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001;98: 6917–6922.CrossRefGoogle ScholarPubMed
Abi-Dargham, A, Mawlawi, O, Lombardo, Iet al. Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci 2002;22: 3708–3719.CrossRefGoogle ScholarPubMed
Hallmayer, JF, Jablensky, AV, Michie, PTet al. Linkage analysis of candidate regions using a composite neurocognitive phenotype correlated with schizophrenia. Mol Psychiatry 2003;8: 511–523.CrossRefGoogle ScholarPubMed
Gold, JM, Randolph, C, Carpenter, CJ, Goldberg, TE, Weinberger, DR. Forms of memory failure in schizophrenia. J Abnorm Psychol 1992;101: 487–494.CrossRefGoogle ScholarPubMed
McKenna, PJ, Tamlyn, D, Lund, CE, Mortimer, AM, Hammond, S, Baddeley, AD. Amnesic syndrome in schizophrenia. Psychol Med 1990;20: 967–972.CrossRefGoogle ScholarPubMed
Goldman-Rakic, PS. Functional architecture of working memory and disordered cognition in schizophrenia. Biol Psychiatry 1999;46: 650–661.CrossRefGoogle ScholarPubMed
Callicott, JH, Bertolino, A, Mattay, VSet al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 2000;10: 1078–1092.CrossRefGoogle ScholarPubMed
Weinberger, DR, Egan, MF, Bertolino, Aet al. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 2001;50: 825–844.CrossRefGoogle ScholarPubMed
Baddeley, A. Working Memory. Oxford, England: Claredon Press, 1986. Google ScholarPubMed
Perry, W, Heaton, RK, Potterat, E, Roebuck, T, Minassian, A, Braff, DL. Working memory in schizophrenia: transient ‘online’ storage versus executive functioning. Schizophr Bull 2001;27: 157–176.CrossRefGoogle ScholarPubMed
Goldberg, TE, Torrey, EF, Gold, JM, Ragland, JD, Bigelow, LB, Weinberger, DR. Learning and memory in monozygotic twins discordant for schizophrenia. Psychol Med 1993;23: 71–85.CrossRefGoogle ScholarPubMed
Conklin, HM, Curtis, CE, Katsanis, J, Iacono, WG. Verbal working memory impairment in schizophrenia patients and their first-degree relatives: evidence from the digit span task. Am J Psychiatry 2000;157: 275–277.CrossRefGoogle ScholarPubMed
Goldberg, TE, Weinberger, DR. Thought disorder, working memory and attention: interrelationships and the effects of neuroleptic medications. Int Clin Psychopharmacol 1995;10: 99–104.Google ScholarPubMed
Kremen, WS, Seidman, LJ, Pepple, JR, Lyons, MJ, Tsuang, MT, Faraone, SV. Neuropsychological risk indicators for schizophrenia: a review of family studies. Schizophr Bull 1994;20: 103–119.CrossRefGoogle ScholarPubMed
Shedlack, K, Lee, G, Sakuma, Met al. Language processing and memory in ill and well siblings from multiplex families affected with schizophrenia. Schizophr Res 1997;25: 43–52.CrossRefGoogle ScholarPubMed
Harris, JG, Adler, LE, Young, DAet al. Neuropsychological dysfunction in parents of schizophrenics. Schizophr Res 1996;20: 253–260.CrossRefGoogle ScholarPubMed
Laurent, A, Saoud, M, Bougerol, Tet al. Attentional deficits in patients with schizophrenia and in their non-psychotic first-degree relatives. Psychiatry Res 1999;89: 147–159.CrossRefGoogle ScholarPubMed
Wechsler, D. Wechsler Memory Scale, 3rd edn. San Antonio, TX: The Psychological Corporation, 1997. Google Scholar
Wing, JK, Babor, T, Brugha, Tet al. Schedules for clinical assessment in neuropsychiatry. Arch General Psychiatry 1990;47: 589–593. CrossRefGoogle ScholarPubMed
World Health Organization. The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. Geneva: WHO, 1993. Google Scholar
American Psychiatric Association CoNaS. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Washington, DC: American Psychiatric Association, 1994. Google Scholar
Nelson, HE & Willison, JR. The Revised National Adult Reading Test-Test Manual. Windsor: NFER- Nelson, 1991. Google Scholar
Michie, PT, Kent, A, Stienstra, Ret al. Phenotypic markers as risk factors in schizophrenia: neurocognitive functions. Aust NZ J Psychiatry 2000;34: S74–S85. CrossRefGoogle ScholarPubMed
Gold, JM, Carpenter, C, Randolph, C, Goldberg, TE, Weinberger, DR. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry 1997;54: 159–165.CrossRefGoogle ScholarPubMed
Park, S, Holzman, PS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry 1992;49: 975–982.CrossRefGoogle ScholarPubMed
Hartman, M, Steketee, MC, Silva, S, Lanning, K, McCann, H. Working memory and schizophrenia: evidence for slowed encoding. Schizoph Res 2002;59: 99–113. CrossRefGoogle Scholar
Kremen, WS, Faraone, SV, Seidman, LJ, Pepple, JR, Tsuang, MT. Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probands. Psychiatry Res 1998;79: 227–240.CrossRefGoogle ScholarPubMed