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A decade of biological-psychiatric research in OCD (II): challenge-studies and neuroanatomical substrate

Published online by Cambridge University Press:  18 September 2015

A.S. De Leeuw ,
H.G.M. Westenberg  and
J.A. Den Boer
A.S. De Leeuw*
Affiliation:
afd. biologische psychiatrie, AZU
H.G.M. Westenberg
Affiliation:
afd. biologische psychiatrie, AZU
J.A. Den Boer
Affiliation:
afd. biologische psychiatrie, AZU
*
Academisch Ziekenhuis Utrecht, Afdeling Biologische Psychiatrie, Heidelberglaan 100, 3584 CX Utrecht
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Summary

In this second part of a review on OCD, challenge-tests are discussed and an overview is given of neuro-imaging studies. Subsequently some hypotheses concerning the pathogenesis of OCD are reviewed. The serotonin (5-HT) agonist metachloro-phenylpiperazine (mCPP) was found to lead to an increase in obsessive-compulsive symptoms. These studies revealed a dissociation between the behavioral and the neuroendocrine responses: OCD-patients showed a blunted hormonal respons compared to controls. Possibly different receptor subtypes are involved. One study is reported with a 5-HT1a agonist as a probe. This study lends no support to an involvement of the 5-HT1a receptor. Tests with noradrenergic probes showed unequivocal results.

Research on the neuroanatomic substrate of OCD is critically reviewed. PET-scan studies point to a possible role of the (orbito-)frontal cortex and the basal ganglia in OCD. Keywords: obsessive-compulsive disorder, OCD, challenge-test, serotonin (5-HT), mCPP, PET-scan.

Type
Research Article
Information
Acta Neuropsychiatrica , Volume 5 , Issue 1 , March 1993 , pp. 7 - 14
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1993

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References

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