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Contribution of nociceptin/orphanin FQ receptors to the anti-nociceptive and hypothermic effects of dipyrone

Published online by Cambridge University Press:  03 December 2014

Ismet Hande Ertin ,
Ozgur Gunduz  and
Ahmet Ulugol
Ismet Hande Ertin
Affiliation:
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey
Ozgur Gunduz
Affiliation:
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey
Ahmet Ulugol*
Affiliation:
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, Edirne, Turkey
*
Prof. Ahmet Ulugol, Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030-Edirne, Turkey. Tel/Fax: +90 284 235 3925 E-mail: [email protected]; [email protected]
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Abstract

Background

Dipyrone is one of the most commonly used non-opioid analgesic and antipyretic drug. Its anti-nociceptive and hypothermic effects have long been suspected to be centrally mediated. The involvement of the most recently discovered opioid peptide, nociceptin/orphanin FQ (N/OFQ), and its receptor (NOP) in pain transmission is controversial. It appears to be pro-nociceptive when administered supra-spinally, but exerts anti-nociceptive effects when injected spinally or systemically.

Objective

Investigation of the role of the N/OFQ system in paracetamol-induced anti-nociception and hypothermia led us to determine its role in the anti-nociceptive and hypothermic effects of dipyrone.

Material and Methods

Hot-plate and tail-flick tests were used to assess nociception, and a rectal thermometer was used to measure rectal temperature in mice.

Results

Mice injected with dipyrone (150, 300, 600 mg/kg, i.p.) displayed dose-related anti-nociception and hypothermia. The NOP receptor antagonist JTC-801 (3 mg/kg, i.p.), at a dose that exerted no effect when used alone, alleviated dipyrone-induced anti-nociception but did not reverse dipyrone-induced hypothermia.

Conclusion

We conclude that NOP receptors participate in the anti-nociceptive, but not in the hypothermic, effects of dipyrone.

Keywords

anti-nociceptiondipyronehypothermiaJTC-801N/OFQ
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 27 , Issue 1 , February 2015 , pp. 48 - 52
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Copyright
© Scandinavian College of Neuropsychopharmacology 2014 

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