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The clinical significance of atypical antipsychotics

Published online by Cambridge University Press:  18 September 2015

J.A. Den Boer ,
H.G.M. Westenberg ,
J.W. Louwerens  and
C.J. Slooff
J.A. Den Boer*
Affiliation:
psychiater en klinisch farmacoloog verbonden aan de Afdeling Biologische, Psychiatrie van het AZU
H.G.M. Westenberg
Affiliation:
psychiater en klinisch farmacoloog verbonden aan de Afdeling Biologische, Psychiatrie van het AZU
J.W. Louwerens
Affiliation:
psychiater verbonden aan de afdeling psychiatrie van het Academisch Ziekenhuis Groningen, alsmede Psychiatrisch Ziekenhuis Licht en Kracht te Assen
C.J. Slooff
Affiliation:
psychiater verbonden aan de afdeling psychiatrie van het Academisch Ziekenhuis Groningen, alsmede Psychiatrisch Ziekenhuis Licht en Kracht te Assen
*
Universitair Hoofddocent, Klinische en Biologische Psychiatrie Afdeling Biologische Psychiatric Academisch Ziekenhuis Utrecht Postbus 85500, 3508 GA Utrecht
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Summary

A concise review is given of the importance of the atypical antipsychotic drugs clozapine, sulpiride, remoxipride and raclopride. Both the concept of atypicality and the pharmacological profile of these compounds is discussed. The newly developed atypical antipsychotic remoxipride has been studied in several double blind studies. In virtually all of these studies a reduced propensity for the induction of extrapyramidal symptoms was found.

These findings implicate that atypical antipsychotics may also not induce tardive dyskinesia. In addition to the treatment of acute schizophrenia, these compounds might be of use in the treatment of treatment resistent schizophrenia (clozapine), tardive dyskinesia and psychosis during the course of Parkinson's disease.

Keywords

atypical antipsychoticsdopamine D2-receptorsschizophreniaextrapyramidal symptomsatypische antipsychoticadopamine D2-receptorenschizofrenieextrapiramidale Symptomen
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 3 , Issue 4 , December 1991 , pp. 55 - 60
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1991

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