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Clinical, cognitive and neural correlates of self-monitoring deficits in schizophrenia: an update

Published online by Cambridge University Press:  24 June 2014

Vinodkumar Raveendran  and
Veena Kumari
Vinodkumar Raveendran*
Affiliation:
Departments of Psychology Neuroscience, Institute of Psychiatry, King’s College London, London, UK
Veena Kumari
Affiliation:
Departments of Psychology
*
Vinodkumar Raveendran, MB BS, MD, Department of Psychology, PO Box 78, Institute of Psychiatry, King’s College London, De Crespigny Park, London SE5 8AF, UK. Tel: 44 207 848 0978; Fax: 44 207 848 0646; E-mail: [email protected]
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Abstract

Background:

An area of recent interest in schizophrenia research is to investigate specific neural and cognitive abnormalities associated with symptoms of this disorder.

Objective:

To establish clinical, cognitive and neural correlates of self-monitoring deficits in schizophrenia, which according to various theoretical models can account for the first-rank symptoms of this disorder.

Methods:

Relevant data were identified from PubMed and PsycInfo searches up to July 2006 using combinations of keywords including ‘self-monitoring’, ‘symptoms’, ‘self-agency’, ‘neuropsychological’, ‘cognitive’, ‘brain activity’, ‘PET’ and ‘fMRI’.

Conclusions:

Self-monitoring deficit is most consistently observed in patients with schizophrenia with auditory hallucinations and passivity experiences. This deficit may not be schizophrenia specific. At present, there are insufficient direct data to reach meaningful conclusions about the cognitive correlates of this deficit. Functional neuroimaging studies in patients with schizophrenia with auditory hallucinations point to defective engagement of the neural regions known to be involved in self-monitoring in healthy people. Further multimodal studies using validated cognitive and clinical measures, self-monitoring paradigms and appropriate imaging tools to analyze patients with schizophrenia with and without self-monitoring deficits are required to increase our understanding of this topic.

Keywords

imagingneural regionsschizophreniaself-agencyself-monitoringsymptoms
Type
Review article
Information
Acta Neuropsychiatrica , Volume 19 , Issue 1 , February 2007 , pp. 27 - 37
Copyright
Copyright © 2007 Blackwell Munksgaard

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