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Clinical and neurochemical characteristics of pediatric multiple sclerosis – CSF analysis as knowledge base for differential diagnosis and pathophysiology

Published online by Cambridge University Press:  24 June 2014

Kevin Rostasy  and
Hansotto Reiber
Kevin Rostasy
Affiliation:
Department of Pediatrics IV, Division of Pediatric Neurology, Inborn Errors of Metabolism and Developmental Neurology, Medical University of Innsbruck, Innsbruck, Austria
Hansotto Reiber
Affiliation:
Neurochemistry Laboratory, Department of Neurology, Georg-August University Göttingen, Germany
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Abstract:

Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system affecting young adults. Although adults and children share important features of the disease, they also differ in some clinical, radiological and laboratory aspects. This review focuses on the neuroimmunological findings in the cerebrospinal fluid of children with MS pointing out that there is already at earliest time of clinical manifestation a neuroimmunological pattern, which differs only in intensity of the humoral immune response but not in frequency and does not support a neuroimmunological difference between early onset from adult onset MS. The humoral immune response with intrathecal IgG and IgM class response and the polyspecific production of antibodies against a wide range of antigens (MRZ antibody response) further helps to differentiate childhood MS from ADEM as the main differential diagnostic challenge.

Type
Main Theme: Multiple Sclerosis
Information
Acta Neuropsychiatrica , Volume 21 , Issue S2: Special Issue: Abstracts of 49th Neuropsychiatric Pula Congress, 17-20 June 2009, Pula, Croatia , June 2009 , pp. 20 - 21
Copyright
Copyright © 2009 John Wiley & Sons A/S

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