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Benzodiazepinen in perspectief (I): De GABAA-benzodiazepine-receptor

Published online by Cambridge University Press:  18 September 2015

P.J.L. Vermeulen  and
F.G. Zitman
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Summary

In this first part of a review on recent insights into the structure and function of the γ-aminobuty rie acid type A - benzodiazepine receptor system, the γ-aminobutyric acid type A (GABAA) receptor and the different types of benzodiazepine (BDZ) receptors known at this moment are dicussed. GABAA- and BDZ receptors are coupled in a supramolecular GABAA-BDZ-ionophore receptor complex, each consisting of five acidic glycoprotein molecules called subunits. These subunits can be classified into five groups: α, β, γ, σ and ρ. Present evidence indicates the existence of multiple subtypes of these subunits. Multiple GABAA-BDZ receptors exist in the brain that show differential distribution and developmental patterns. These receptors differ from their subunit composition. The final functional properties of the receptor are determined by the different subunits constituting this receptor. Heterogeneity among α- subunits may determine the diversity of BDZ pharmacology in different regions of the nervous system.

Keywords

GABAA receptorsbenzodiazepine receptorsmacromolecular systemprotein conformationmodulationligandscentral nervous systemGABAA-receptorsbenzodiazepine-receptorsmacromoleculair systeemproteïne conformanemodulatieligandencentraal zenuwstelsel
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 8 , Issue 3 , September 1996 , pp. 48 - 55
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1996

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