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Test-retest reliability of prepulse inhibition (PPI) and PPI correlation with working memory

Published online by Cambridge University Press:  12 August 2022

Florian Freudenberg Open the ORCID record for Florian Freudenberg [Opens in a new window] ,
Heike Althen ,
Kim Falk ,
Robert A. Bittner Open the ORCID record for Robert A. Bittner [Opens in a new window] ,
Andreas Reif Open the ORCID record for Andreas Reif [Opens in a new window]  and
Michael M. Plichta Open the ORCID record for Michael M. Plichta [Opens in a new window]
Florian Freudenberg*
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt Heinrich Hoffmann Straße 10, 60528 Frankfurt, Germany
Heike Althen
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt Heinrich Hoffmann Straße 10, 60528 Frankfurt, Germany
Kim Falk
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt Heinrich Hoffmann Straße 10, 60528 Frankfurt, Germany
Robert A. Bittner
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt Heinrich Hoffmann Straße 10, 60528 Frankfurt, Germany Ernst Strüngmann Institute for Neuroscience (ESI) in Cooperation with Max Planck Society, Deutschordenstraße 46, 60528 Frankfurt am Main, Germany
Andreas Reif
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt Heinrich Hoffmann Straße 10, 60528 Frankfurt, Germany
Michael M. Plichta
Affiliation:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital, Goethe University, Frankfurt Heinrich Hoffmann Straße 10, 60528 Frankfurt, Germany
*
Author for correspondence: Florian Freudenberg, Email: [email protected]
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Abstract

Objective:

Sensorimotor gating is experimentally operationalized by the prepulse inhibition (PPI) of the startle response (SR). Previous studies suggest high test-retest reliability of PPI and potential correlation with working memory (WM). Here, we aimed to validate and extend the test-retest reliability of PPI in healthy humans and its correlation with WM performance.

Methods:

We applied an acoustic startle PPI paradigm with four different prepulse intensities (64, 68, 72 and 76 dB) and two different WM tasks [n-back, change detection task (CDT)] in a group of 26 healthy adults (final sample size n = 23). To assess test-retest reliability, we performed all tests on two separate days ~27 days (range: 21–32 days) apart.

Results:

We were able to confirm high test-retest reliability of the PPI with a mean intraclass correlation (ICC) of > 0.80 and significant positive correlation of PPI with n-back but not with CDT performance. Detailed analysis showed that PPI across all prepulse intensities significantly correlated with both the 2-back and 0-back conditions, suggesting regulation by cross-conditional processes (e.g. attention). However, when removing the 0-back component from the 2-back data, we found a specific and significant correlation with WM for the 76-dB PPI condition.

Conclusion:

With the present study, we were able to confirm the high test-retest reliability of the PPI in humans and could validate and expand on its correlation with WM performance.

Keywords

PPIstartlesensorimotor gatingworking memorytest-retest
Type
Original Article
Information
Acta Neuropsychiatrica , Volume 34 , Issue 6 , December 2022 , pp. 344 - 353
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology

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Footnotes

#

These authors are contributed equally to this work (shared first-authorship).

References

Aasen, I, Kolli, L and Kumari, V (2005) Sex effects in prepulse inhibition and facilitation of the acoustic startle response: implications for pharmacological and treatment studies. Journal of Psychopharmacology (Oxford, England) 19, 39–45.CrossRefGoogle ScholarPubMed
Abel, K, Waikar, M, Pedro, B, Hemsley, D and Geyer, M (1998) Repeated testing of prepulse inhibition and habituation of the startle reflex: a study in healthy human controls. Journal of Psychopharmacology (Oxford, England) 12, 330–337.CrossRefGoogle ScholarPubMed
Ackenheil, M, Stotz, G, Dietz-Bauer, R and Vossen, A (1999) M.I.N.I, Mini international neuropsychiatric interview, German version 5.0.0 DSM-IV, Psychiatrische Universitätsklinik München. Google Scholar
Bak, N, Mann, J, Fagerlund, B, Glenthøj, BY, Jepsen, JRM and Oranje, B (2017) Testing a decades’ old assumption: Are individuals with lower sensory gating indeed more easily distracted? Psychiatry Research 255, 387–393.CrossRefGoogle ScholarPubMed
Barnes-Scheufler, CV, Passow, C, Rösler, L, Mayer, JS, Oertel, V, Kittel-Schneider, S, Matura, S, Reif, A and Bittner, RA (2021) Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia. International Journal of Bipolar Disorders 9, 12.CrossRefGoogle ScholarPubMed
Bitsios, P and Giakoumaki, SG (2005) Relationship of prepulse inhibition of the startle reflex to attentional and executive mechanisms in man. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology 55, 229–241.CrossRefGoogle ScholarPubMed
Bitsios, P, Giakoumaki, SG, Theou, K and Frangou, S (2006) Increased prepulse inhibition of the acoustic startle response is associated with better strategy formation and execution times in healthy males. Neuropsychologia 44, 2494–2499. doi: 10.1016/j.neuropsychologia.2006.04.001.CrossRefGoogle ScholarPubMed
Bittner, RA, Linden, DEJ, Roebroeck, A, Härtling, F, Rotarska-Jagiela, A, Maurer, K, Goebel, R, Singer, W and Haenschel, C (2015) The when and where of working memory dysfunction in early-Onset schizophrenia-A functional magnetic resonance imaging study. Cerebral Cortex (New York, N.Y.: 1991) 25, 2494–2506.CrossRefGoogle ScholarPubMed
Bouchacourt, F and Buschman, TJ (2019) A flexible model of working memory. Neuron 103(1), 147–160.e8.CrossRefGoogle ScholarPubMed
Braff, DL and Geyer, MA (1990) Sensorimotor gating and schizophrenia. Human and animal model studies. Archives of General Psychiatry 47, 181–188.CrossRefGoogle ScholarPubMed
Braff, DL, Grillon, C and Geyer, MA (1992) Gating and habituation of the startle reflex in schizophrenic patients. Archives of General Psychiatry 49, 206–215.CrossRefGoogle ScholarPubMed
Cadenhead, KS, Addington, J, Cannon, TD, Cornblatt, BA, de la Fuente-Sandoval, C, Mathalon, DH, Perkins, DO, Seidman, LJ, Tsuang, M, Walker, EF, Woods, SW, Bachman, P, Belger, A, Carrión, RE, Donkers, FCL, Duncan, E, Johannesen, J, León-Ortiz, P, Light, G, Mondragón, A, Niznikiewicz, M, Nunag, J, Roach, BJ, Solís-Vivanco, R and North American Prodromal Longitudinal Studies Consortium (2013) Between-site reliability of startle prepulse inhibition across two early psychosis consortia. Neuroreport 24, 626–630.CrossRefGoogle ScholarPubMed
Callicott, JH, Ramsey, NF, Tallent, K, Bertolino, A, Knable, MB, Coppola, R, Goldberg, T, van Gelderen, P, Mattay, VS, Frank, JA, Moonen, CT, Weinberger, DR (1998) unctional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 18, 186–196.CrossRefGoogle Scholar
Constantinidis, C, Forest, W, Carolina, N, Inserm, U and Fédératif, I (2004) Working memory networks. Cognitive, Affective, & Behavioral Neuroscience 4, 444–465.CrossRefGoogle ScholarPubMed
Constantinidis, C and Klingberg, T (2016) The neuroscience of working memory capacity and training. Nature Reviews Neuroscience 17(7), 438–449.CrossRefGoogle ScholarPubMed
Csomor, PA, Stadler, RR, Feldon, J, Yee, BK, Geyer, MA and Vollenweider, FX (2008) Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 33, 497–512.CrossRefGoogle ScholarPubMed
Csomor, PA, Vollenweider, FX, Feldon, J and Yee, BK (2005) On the feasibility to detect and to quantify prepulse-elicited reaction in prepulse inhibition of the acoustic startle reflex in humans. Behavioural Brain Research 162, 256–263.CrossRefGoogle ScholarPubMed
Cuthbert, BN (2014) The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry 13, 28–35.CrossRefGoogle ScholarPubMed
Dawson, ME, Hazlett, EA, Filion, DL, Nuechterlein, KH and Schell, AM (1993) Attention and schizophrenia: impaired modulation of the startle reflex. Journal of Abnormal Psychology 102, 633–641.CrossRefGoogle ScholarPubMed
Dias, EC, Butler, PD, Hoptman, MJ and Javitt, DC (2011) Early sensory contributions to contextual encoding deficits in schizophrenia. Archives of General Psychiatry 68, 654–664.CrossRefGoogle Scholar
Du, Y, Wu, X and Li, L (2011) Differentially organized top-down modulation of prepulse inhibition of startle. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 31, 13644–13653.CrossRefGoogle ScholarPubMed
Filion, DL, Dawson, ME and Schell, AM (1993) Modification of the acoustic startle-reflex eyeblink: a tool for investigating early and late attentional processes. Biological Psychology 35, 185–200.CrossRefGoogle ScholarPubMed
Flaten, MA (2002) Test-retest reliability of the somatosensory blink reflex and its inhibition. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology 45, 261–265.CrossRefGoogle ScholarPubMed
Fleiss, JL (1986) The Design and Analysis of Clinical Experiments. New York: John Wiley & Sons.Google Scholar
Ford, JM, Roth, WT, Isaacks, BG, White, PM, Hood, SH and Pfefferbaum, A (1995) Elderly men and women are less responsive to startling noises: N1, P3 and blink evidence. Biological Psychology 39, 57–80.CrossRefGoogle ScholarPubMed
Gajewski, PD, Hanisch, E, Falkenstein, M, Thönes, S and Wascher, E (2018) What does the n-Back task measure as we get older? Relations between working-Memory measures and other cognitive functions across the lifespan. Frontiers in Psychology 9, 2208.CrossRefGoogle ScholarPubMed
Grillon, C, Southwick, SM and Charney, DS (1996) The psychobiological basis of posttraumatic stress disorder. Molecular Psychiatry 1, 278–297.Google ScholarPubMed
Haenschel, C, Bittner, RA, Haertling, F, Rotarska-Jagiela, A, Maurer, K, Singer, W and Linden, DEJ (2007) Contribution of impaired early-stage visual processing to working memory dysfunction in adolescents with schizophrenia: a study with event-related potentials and functional magnetic resonance imaging. Archives of General Psychiatry 64, 1229–1240.CrossRefGoogle ScholarPubMed
Hahn, B, Robinson, BM, Kaiser, ST, Harvey, AN, Beck, VM, Leonard, CJ, Kappenman, ES, Luck, SJ and Gold, JM (2010) Failure of schizophrenia patients to overcome salient distractors during working memory encoding. Biological Psychiatry 68, 603–609.CrossRefGoogle ScholarPubMed
Hampson, E and Morley, EE (2013) Estradiol concentrations and working memory performance in women of reproductive age. Psychoneuroendocrinology 38, 2897–2904.CrossRefGoogle ScholarPubMed
Hessl, D, Berry-Kravis, E, Cordeiro, L, Yuhas, J, Ornitz, EM, Campbell, A, Chruscinski, E, Hervey, C, Long, JM, Hagerman, RJ (2009) Prepulse inhibition in fragile X syndrome: feasibility, reliability, and implications for treatment. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : The Official Publication of the International Society of Psychiatric Genetics 150B, 545–553.CrossRefGoogle ScholarPubMed
Hidalgo-Lopez, E and Pletzer, B (2021) Fronto-striatal changes along the menstrual cycle during working memory: Effect of sex hormones on activation and connectivity patterns. Psychoneuroendocrinology 125, 105108.CrossRefGoogle ScholarPubMed
Holstein, DH, Csomor, PA, Geyer, MA, Huber, T, Brugger, N, Studerus, E and Vollenweider, FX (2011) The effects of sertindole on sensory gating, sensorimotor gating, and cognition in healthy volunteers. Journal of Psychopharmacology (Oxford, England) 25, 1600–1613.CrossRefGoogle ScholarPubMed
Insel, T, Cuthbert, B, Garvey, M, Heinssen, R, Pine, DS, Quinn, K, Sanislow, C and Wang, P (2010) Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. The American Journal of Psychiatry 167, 748–751.CrossRefGoogle Scholar
Inui, K, Takeuchi, N, Sugiyama, S, Motomura, E and Nishihara, M (2018) GABAergic mechanisms involved in the prepulse inhibition of auditory evoked cortical responses in humans. PLoS ONE 13, 1–15.CrossRefGoogle ScholarPubMed
Jacobs, E and D’Esposito, M (2011) Estrogen shapes dopamine-dependent cognitive processes: Implications for women’s health. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 31, 5286–5293.CrossRefGoogle ScholarPubMed
Jafari, Z, Kolb, BE and Mohajerani, MH (2020) Prepulse inhibition of the acoustic startle reflex and P50 gating in aging and alzheimer’s disease. Ageing Research Reviews 59(Suppl.1), 101028.CrossRefGoogle ScholarPubMed
Joseph, JE, Swearingen, JE, Corbly, CR, Curry, TE and Kelly, TH (2012) Influence of estradiol on functional brain organization for working memory. NeuroImage 59, 2923–2931.CrossRefGoogle ScholarPubMed
Jovanovic, T, Szilagyi, S, Chakravorty, S, Fiallos, AM, Lewison, BJ, Parwani, A, Schwartz, MP, Gonzenbach, S, Rotrosen, JP, Duncan, EJ (2004) Menstrual cycle phase effects on prepulse inhibition of acoustic startle. Psychophysiology 41, 401–406.CrossRefGoogle ScholarPubMed
Kane, MJ, Conway, ARA, Miura, TK and Colflesh, GJH (2007) Working memory, attention control, and the N-back task: A question of construct validity. Journal of Experimental Psychology. Learning, Memory, and Cognition 33, 615–622.CrossRefGoogle ScholarPubMed
Kask, K, Bäckström, T, Gulinello, M and Sundström-Poromaa, I (2008) Lower levels of prepulse inhibition of startle response in pregnant women compared to postpartum women. Psychoneuroendocrinology 33, 100–107.CrossRefGoogle ScholarPubMed
Katsuki, F and Constantinidis, C (2014) Bottom-up and top-down attention: Different processes and overlapping neural systems. Neuroscientist 20, 509–521.CrossRefGoogle ScholarPubMed
Koch, M (1999) The neurobiology of startle. Progress in Neurobiology 59, 107–128.CrossRefGoogle ScholarPubMed
Koch, M and Schnitzler, HU (1997) The acoustic startle response in rats - circuits mediating evocation, inhibition and potentiation. Behavioural Brain Research 89, 35–49.CrossRefGoogle ScholarPubMed
Kohl, S, Heekeren, K, Klosterkötter, J and Kuhn, J (2013) Prepulse inhibition in psychiatric disorders - Apart from schizophrenia. Journal of Psychiatric Research 47, 445–452.CrossRefGoogle ScholarPubMed
Kuchenbecker, J and Broschmann, D (2016) Tafeln zur Prüfung des Farbensinnes / Farbensehens, 35th edn. Thieme.Google Scholar
Kumari, V, Aasen, I, Papadopoulos, A, Bojang, F, Poon, L, Halari, R and Cleare, AJ (2008) A comparison of prepulse inhibition in pre- and postmenopausal women and age-matched men. Neuropsychopharmacology 33, 2610–2618.CrossRefGoogle ScholarPubMed
Kumari, V, Konstantinou, J, Papadopoulos, A, Aasen, I, Poon, L, Halari, R and Cleare, AJ (2010) Evidence for a role of progesterone in menstrual cycle-related variability in prepulse inhibition in healthy young women. Neuropsychopharmacology 35, 929–937.CrossRefGoogle ScholarPubMed
Lehrl, S, Triebig, G and Fischer, B (1995) Multiple choice vocabulary test MWT as a valid and short test to estimate premorbid intelligence. Acta Neurologica Scandinavica 91, 335–345.CrossRefGoogle ScholarPubMed
Lim, S and Goldman, MS (2013) Balanced cortical microcircuitry for maintaining information in working memory. Nature Neuroscience 16, 1306–1314.CrossRefGoogle ScholarPubMed
Longenecker, RJ, Alghamdi, F, Rosen, MJ and Galazyuk, AV (2016) Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment. Hearing Research 339, 80–93.CrossRefGoogle ScholarPubMed
Ludewig, K, Geyer, MA, Etzensberger, M and Vollenweider, FX (2002) Stability of the acoustic startle reflex, prepulse inhibition, and habituation in schizophrenia. Schizophrenia Research 55, 129–137.CrossRefGoogle Scholar
Mao, Z, Bo, Q, Li, W, Wang, Z, Ma, X and Wang, C (2019) Prepulse inhibition in patients with bipolar disorder: A systematic review and meta-analysis. BMC Psychiatry 19, 282.CrossRefGoogle ScholarPubMed
Mishra, J, Fellous, JM and Sejnowski, TJ (2006) Selective attention through phase relationship of excitatory and inhibitory input synchrony in a model cortical neuron. Neural Networks 19, 1329–1346.CrossRefGoogle Scholar
Molina, JL, Voytek, B, Thomas, ML, Joshi, YB, Bhakta, SG, Talledo, JA, Swerdlow, NR and Light, GA (2020) Memantine effects on electroencephalographic measures of putative excitatory/inhibitory balance in schizophrenia. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging 5, 562–568.CrossRefGoogle Scholar
Murray, JD, Anticevic, A, Gancsos, M, Ichinose, M, Corlett, PR, Krystal, JH and Wang, XJ (2014) Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model. Cerebral Cortex 24, 859–872.CrossRefGoogle Scholar
Noble, S, Scheinost, D and Constable, RT (2019) A decade of test-retest reliability of functional connectivity: A systematic review and meta-analysis. NeuroImage 203, 116157.CrossRefGoogle ScholarPubMed
Oldfield, RC (1971) The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 9, 97–113.CrossRefGoogle ScholarPubMed
Oliveras, I, Río-Álamos, C, Cañete, T, Blázquez, G, Martínez-Membrives, E, Giorgi, O, Corda, MG, Tobeña, A and Fernández-Teruel, A (2015) Prepulse inhibition predicts spatial working memory performance in the inbred roman high- and low-avoidance rats and in genetically heterogeneous NIH-HS rats: relevance for studying pre-attentive and cognitive anomalies in schizophrenia. Frontiers in Behavioral Neuroscience 9, 127. doi: 10.3389/fnbeh.2015.00213.CrossRefGoogle Scholar
Peleg-Raibstein, D, Philipp, S, Feldon, J and Yee, BK (2015) Individual difference in prepulse inhibition does not predict spatial learning and memory performance in C57BL/6 mice. Cognitive, Affective & Behavioral Neuroscience 15, 878–888.CrossRefGoogle Scholar
Poje, AB and Filion, DL (2021) Effects of prepulse format and lead interval on the assessment of automatic and attention-modulated prepulse inhibition. Cognitive Processing 22, 559–567.CrossRefGoogle ScholarPubMed
Quednow, BB, Kühn, K-U, Beckmann, K, Westheide, J, Maier, W and Wagner, M (2006) Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions. Biological Psychology 71, 256–263.CrossRefGoogle ScholarPubMed
Rosenberg, L and Park, S (2002) Verbal and spatial functions across the menstrual cycle in healthy young women. Psychoneuroendocrinology 27, 835–841.CrossRefGoogle ScholarPubMed
Scholes, KE and Martin-Iverson, MT (2009) Relationships between prepulse inhibition and cognition are mediated by attentional processes. Behavioural Brain Research 205, 456–467.CrossRefGoogle ScholarPubMed
Schwarzkopf, SB, McCoy, L, Smith, DA and Boutros, NN (1993) Test-retest reliability of prepulse inhibition of the acoustic startle response. Biological Psychiatry 34, 896–900.CrossRefGoogle ScholarPubMed
Shrout, PE and Fleiss, JL (1979) Intraclass correlations: Uses in assessing rater reliability. Psychological Bulletin 86, 420–428. doi: 10.1037//0033-2909.86.2.420.CrossRefGoogle ScholarPubMed
Singer, P, Hauser, J, Llano Lopez, LH, Peleg-Raibstein, D, Feldon, J, Gargiulo, PA and Yee, BK (2013) Prepulse inhibition predicts working memory performance whilst startle habituation predicts spatial reference memory retention in C57BL/6 mice. Behavioural Brain Research 242(Suppl. 1), 166–177.CrossRefGoogle ScholarPubMed
Snyder, AC, Morais, MJ and Smith, MA (2016) Dynamics of excitatory and inhibitory networks are differentially altered by selective attention. Journal of Neurophysiology 116, 1807–1820.CrossRefGoogle ScholarPubMed
Sohal, VS and Rubenstein, JLR (2019) Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders. Molecular Psychiatry 24, 1248–1257.CrossRefGoogle ScholarPubMed
Squire, LR and Dede, AJO (2015) Conscious and unconscious memory systems. Cold Spring Harbor Perspectives in Biology 7, a021667.CrossRefGoogle ScholarPubMed
Storozheva, ZI, Akhapkin, RV, Bolotina, OV, Korendrukhina, A, Novototsky-Vlasov, VY, Shcherbakova, IV and Kirenskaya, AV (2021) Sensorimotor and sensory gating in depression, anxiety, and their comorbidity. The World Journal of Biological Psychiatry: The Official Journal of the World Federation of Societies of Biological Psychiatry 22, 183–193.CrossRefGoogle ScholarPubMed
Swerdlow, NR, Auerbach, P, Monroe, SM, Hartston, H, Geyer, MA and Braff, DL (1993) Men are more inhibited than women by weak prepulses. Biological Psychiatry 34, 253–260.CrossRefGoogle ScholarPubMed
Swerdlow, NR, Bhakta, S, Chou, H-H, Talledo, JA, Balvaneda, B and Light, GA (2016) Memantine effects on sensorimotor gating and mismatch negativity in patients with chronic psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 41, 419–430.CrossRefGoogle ScholarPubMed
Swerdlow, NR, Bhakta, SG, Rana, BK, Kei, J, Chou, H-H and Talledo, JA (2017) Sensorimotor gating in healthy adults tested over a 15 year period. Biological Psychology 123, 177–186.CrossRefGoogle Scholar
Swerdlow, NR, Hartman, PL and Auerbach, PP (1997) Changes in sensorimotor inhibition across the menstrual cycle: Implications for neuropsychiatric disorders. Biological Psychiatry 41, 452–460.CrossRefGoogle ScholarPubMed
Swerdlow, NR, Koob, GF, Geyer, MA, Mansbach, R and Braff, DL (1988) A cross-species model of psychosis: sensorimotor gating deficits in schizophrenic patients and dopaminergically activated rats . In An Inquiry into Schizophrenia and Depression, pp. 1–18.Google Scholar
Takahashi, H, Iwase, M, Canuet, L, Yasuda, Y, Ohi, K, Fukumoto, M, Iike, N, Nakahachi, T, Ikezawa, K, Azechi, M, Kurimoto, R, Ishii, R, Yoshida, T, Kazui, H, Hashimoto, R, Takeda, M (2010) Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy japanese subjects. Psychophysiology 47, 831–837.Google ScholarPubMed
Togay, B, Çıkrıkçılı, U, Bayraktaroglu, Z, Uslu, A, Noyan, H and Üçok, A (2020) Lower prepulse inhibition in clinical high-risk groups but not in familial risk groups for psychosis compared with healthy controls. Early Intervention in Psychiatry 14, 196–202.CrossRefGoogle Scholar
Valle-León, M, Callado, LF, Aso, E, Cajiao-Manrique, MM, Sahlholm, K, López-Cano, M, Soler, C, Altafaj, X, Watanabe, M, Ferré, S, Fernández-Dueñas, V, Menchón, JM, Ciruela, F (2021) Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia. Neuropsychopharmacology 46, 665–672.CrossRefGoogle Scholar
Vitale, F, Capozzo, A, Mazzone, P and Scarnati, E (2019) Neurophysiology of the pedunculopontine tegmental nucleus. Neurobiology of Disease 128, 19–30.CrossRefGoogle ScholarPubMed
Wake, N, Ishizu, K, Abe, T and Takahashi, H (2021) Prepulse inhibition predicts subjective hearing in rats. Scientific Reports 11, 1–10.CrossRefGoogle ScholarPubMed
Wesemann, W (2002) [Visual acuity measured via the Freiburg visual acuity test (FVT), Bailey Lovie chart and Landolt Ring chart]. Klinische Monatsblatter fur Augenheilkunde 219, 660–667.CrossRefGoogle Scholar
Wu, Z-M, Ding, Y, Jia, H-X and Li, L (2016) Different effects of isolation-rearing and neonatal MK-801 treatment on attentional modulations of prepulse inhibition of startle in rats. Psychopharmacology 233, 3089–3102.CrossRefGoogle ScholarPubMed
Yang, N-B, Tian, Q, Fan, Y, Bo, Q-J, Zhang, L, Li, L and Wang, C-Y (2017) Deficits of perceived spatial separation induced prepulse inhibition in patients with schizophrenia: relationships to symptoms and neurocognition. BMC Psychiatry 17, 135.CrossRefGoogle ScholarPubMed
Yeomans, JS, Bosch, D, Alves, N, Daros, A, Ure, RJ and Schmid, S (2010) GABA receptors and prepulse inhibition of acoustic startle in mice and rats. European Journal of Neuroscience 31, 2053–2061.CrossRefGoogle ScholarPubMed
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