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Simulation study of stimulation parameters in desynchronisation based on the Hodgkin-Huxley small-world neural networks and its possible implications for vagus nerve stimulation

Published online by Cambridge University Press:  24 June 2014

Yan-Long Li ,
Zhao-Yang Chen ,
Jun Ma  and
Yu-Hong Chen
Yan-Long Li*
Affiliation:
Institute of Theoretical Physics, Lanzhou University of Technology, Lanzhou, China
Zhao-Yang Chen
Affiliation:
Department of Mechanical Engineering, University of California, Berkeley, CA, USA
Jun Ma
Affiliation:
Institute of Theoretical Physics, Lanzhou University of Technology, Lanzhou, China
Yu-Hong Chen
Affiliation:
Institute of Theoretical Physics, Lanzhou University of Technology, Lanzhou, China
*
Professor Yan-Long Li, Lanzhou University of Technology, Lanzhou 730050, China. Tel: +86 0931 2973365; Fax: +86 0931 2976040; E-mail: [email protected]
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Abstract

Adopting small-world neural networks of the Hodgkin-Huxley (HH) model, the stimulation parameters in desynchronisation and its possible implications for vagus nerve stimulation (VNS) are numerically investigated. With the synchronisation status of networks to represent epilepsy, then, adding pulse to stimulations to 10% of neurons to simulate the VNS, we obtain the desynchronisation status of networks (representing antiepileptic effects). The simulations show that synchronisation evolves into desynchronisation in the HH neural networks when a part (10%) of neurons are stimulated with a pulse current signal. The network desynchronisation appears to be sensitive to the stimulation parameters. For the case of the same stimulation intensity, weakly coupled networks reach desynchronisation more easily than strongly coupled networks. The network desynchronisation reduced by short-stimulation interval is more distinct than that of induced by long stimulation interval. We find that there exist the optimal stimulation interval and optimal stimulation intensity when the other stimulation parameters remain certain.

Keywords

desynchronisationEEGHodgkin-Huxley modelvagus nerve stimulation
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 20 , Issue 1 , February 2008 , pp. 25 - 32
Copyright
Copyright © 2007 Blackwell Munksgaard

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