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The significance of the expression of Fos protein in the brain for the classification of antipsychotics

Published online by Cambridge University Press:  18 September 2015

J. Korf  and
J.B. Sebens
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Samenvatting

In de afgelopen zes jaar is veel onderzoek verficht naar de effecten van antipsychotica op de regionale c-fos-expressie in de hersenen. Deze benadering biedt in een dierexperimentele proefopzet de mogelijkheid op cellulair niveau de effecten van psychofarmaca te bestuderen. Het fos-gen behoort tot de groep ‘immediate early genes’. Dit zijn genen die de transcriptie van andere, vaak onbekende genen reguleren. Een aantal aspecten van dit mechanisme wordt in deze bijdrage beschreven. Het onderzoek naar de effecten van antipsychotica op c-fos-expressie wordt samengevat en de betekenis voor de classificatie van antipsychotica benadrukt. Het blijkt dat deze farmaca effectief zijn in zowel de (meso)limbische gebieden (als nucleus accumbens, septum en amygdala) als ook in de basale ganglia. De relatieve effecten, wat betreft de c-fos-reactie, van de atypische antipsychotica (als clozapine en risperidon) zijn hoger in de limbische structuren, vergeleken met de effecten van de typische (als haloperidol). De potentie van de c-fos-methodiek voor verdere ontwikkelingen in dit gebied wordt aangegeven.

Keywords

AntipsychoticaFos-eiwittengen-expressielimbische structurenbasale gangliaimmunohistochemieAntipsychotic drugsFos proteinsgene expressionlimbic systembasal gangliaimmunohistochemistry
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 9 , Issue 4 , December 1997 , pp. 143 - 150
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1997

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