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Quetiapine in relapsing schizophrenia: clinical efficacy and effect on monoaminergic parameters

Published online by Cambridge University Press:  24 June 2014

F. M. M. A. van der Heijden ,
W. M. A. Verhoeven ,
D. Fekkes ,
A. E. S. Sijben  and
S. Tuinier
F. M. M. A. van der Heijden*
Affiliation:
Vincent van Gogh Institute for Psychiatry, Venray
W. M. A. Verhoeven
Affiliation:
Vincent van Gogh Institute for Psychiatry, Venray Erasmus University Medical Center, Department of Psychiatry, Rotterdam, the Netherlands
D. Fekkes
Affiliation:
Erasmus University Medical Center, Department of Psychiatry, Rotterdam, the Netherlands
A. E. S. Sijben
Affiliation:
Vincent van Gogh Institute for Psychiatry, Venray
S. Tuinier
Affiliation:
Vincent van Gogh Institute for Psychiatry, Venray
*
Vincent van Gogh Institute for Psychiatry, Stationsweg 46, 5803 AC Venray, the Netherlands. Tel. 31 478527339; Fax: 31 478527110; E-mail: [email protected]
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Abstract

Methods:

Tolerability, safety and effectiveness of quetiapine in an in-patient group with a relapse of schizophrenia and the possible role of plasma amino acid concentrations, 5-HT parameters and HVA in the prediction of response to treatment were investigated in an open-label baseline-controlled trial of 14 weeks in 21 hospitalized schizophrenic patients. Responders were defined as those patients who exhibit at least a 40% reduction of BPRS total scores. Secondary efficacy measures were the PANSS, the Clinical Global Impression (CGI)-severity scale and the MADRS. Extrapyramidal side-effects were evaluated with the AIMS. Other side-effects were monitored at regular intervals. Amino acids and the derived tryptophan and tyrosine ratios, as well as monoaminergic parameters, were assessed in plasma at baseline and at weeks 3, 6 and 14.

Results:

Treatment with quetiapine resulted in the predefined treatment effect in 10 out of the 17 patients who completed at least 4 weeks of treatment. Effect in responders was observed on all efficacy parameters, including lower MADRS scores. No extrapyramidal side-effects emerged. Clinical and biochemical parameters did not predict response to treatment.

Conclusions:

This study demonstrates the moderate antipsychotic efficacy of quetiapine on preferentially positive symptoms in a group of relatively young schizophrenics. Some observed changes in biochemical parameters are discussed.

Keywords

amino acidsmonoaminesquetiapineschizophrenia
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 3 , June 2003 , pp. 133 - 139
Copyright
Copyright © 2003 Blackwell Munksgaard

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