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Plasma homocysteine but not MTHFR gene polymorphism is associated with geriatric depression in the Chinese population

Published online by Cambridge University Press:  24 June 2014

Yong-Gui Yuan ,
Zhi-Jun Zhang  and
Jing-Jing Li
Yong-Gui Yuan*
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, China Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China
Zhi-Jun Zhang
Affiliation:
Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China
Jing-Jing Li
Affiliation:
Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, China
*
Department of Psychiatry, Nanjing Brain Hospital, Nanjing Medical University, No. 264, Guangzhou Road, Nanjing 210029, China. Tel: +86 25 8370 9025; Fax: +86 25 8370 9025; E-mail: [email protected]
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Abstract

Background:

Epidemiological studies suggested that elevated plasma homocysteine (Hcy) is associated with an increased risk of depression and cerebrovascular disease (CVD). There were few published reports of Hcy levels and methylenetetrahydrofolate reductase (MTHFR) C677T genotype in geriatric depression.

Objective:

To investigate the relationship among plasma Hcy level, MTHFR C677T polymorphism and geriatric depression in the Chinese population.

Methods:

The plasma Hcy level measured by capillary electrophoresis with ultraviolet detection and the C667T polymorphism of MTHFR detected using polymerase chain reaction-restriction fragment length polymorphism assay were determined in 116 patients with geriatric depression and in 80 healthy controls.

Results:

The plasma Hcy level in the patients with geriatric depression was significantly higher than that in controls (p < 0.001). The age of first episode and comorbid CVD were significantly correlated with plasma Hcy levels in geriatric patients (p = 0.014 and 0.008, respectively). The Hamilton Rating Scale for Depression total score and plasma Hcy level at baseline showed no significant correlation in the patients (r = −0.111, p = 0.397). There were no significant differences in the MTHFR C677T polymorphism genotypes and alleles between the patients and the healthy controls (p = 0.654 and 0.573, respectively).

Conclusion:

The elevated plasma Hcy level is a risk factor for geriatric depression. MTHFR C667T genotype is not associated with geriatric depression in the Chinese population.

Keywords

geriatric depressionhomocysteineN5N10-methylenetetrahydrofolate reductase
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 20 , Issue 5 , October 2008 , pp. 251 - 255
Copyright
Copyright © 2008 Blackwell Munksgaard

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References

Lewis, SJ, Lawlor, DA, Davey Smith, Get al. The thermolabile variant of MTHFR is associated with depression in the British Women’s Heart and Health Study and a meta-analysis. Mol Psychiatry 2006;11:352–360. CrossRefGoogle ScholarPubMed
Mattson, MP, Shea, TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 2003;26:137–146. CrossRefGoogle ScholarPubMed
Tiemeier, H, Van Tuijl, HR, Hofman, A, Meijer, J, Kiliaan, AJ, Breteler, MM. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry 2002;159:2099–2101. CrossRefGoogle ScholarPubMed
Reutens, S, Sachdev, P. Homocysteine in neuropsychiatric disorders of the elderly. Int J Geriatr Psychiatry 2002;17:859–864. CrossRefGoogle ScholarPubMed
Bjelland, I, Tell, GS, Vollset, SE, Refsum, H, Ueland, PM. Folate, vitamin B12, homocysteine, and the MTHFR 677C>T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry 2003;60:618–626. CrossRefGoogle ScholarPubMed
Papakostas, GI, Petersen, T, Lebowitz, BDet al. The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol 2005;8:523–528. CrossRefGoogle Scholar
Bottiglieri, T, Laundy, M, Crellin, R, Toone, BK, Carney, MW, Reynolds, EH. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 2000;69:228–232. CrossRefGoogle ScholarPubMed
American Psychiatry Association. Diagnostic and statistical manual of mental disorders, Fourth Edition (DSM-IV). Washington: APA, 1994. Google ScholarPubMed
Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62. CrossRefGoogle Scholar
Zhang, YD, Zhu, ZG, Liu, Y. Association of plasma homocysteine level and N5,N10-methylenetrtrahydrofolate reductase gene polymorphism with cerebral infarction. Chin Med Sci J 2001;18:198–200. Google Scholar
Reif, A, Pfuhlmann, B, Lesch, KP. Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:1162–1168. CrossRefGoogle ScholarPubMed
Almeida, OP, Flicker, L, Lautenschlager, NT, Leedman, P, Vasikaran, S, Van Bockxmeer, FM. Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life. Neurobiol Aging 2005;26:251–257. CrossRefGoogle ScholarPubMed
Papakostas, GI, Petersen, T, Mischoulon, Det al. Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 2: predictors of relapse during the continuation phase of pharmacotherapy. J Clin Psychiatry 2004;65:1096–1098. CrossRefGoogle ScholarPubMed
Papakostas, GI, Petersen, T, Mischoulon, Det al. Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression. J Clin Psychiatry 2004;65:1090–1095. CrossRefGoogle ScholarPubMed
Fraguas, R Jr, Papakostas, GI, Mischoulon, D, Bottiglieri, T, Alpert, J, Fava, M. Anger attacks in major depressive disorder and serum levels of homocysteine. Biol Psychiatry 2006;60:270–274. CrossRefGoogle ScholarPubMed
Hickie, I, Scott, E, Naismith, Set al. Late-onset depression: genetic, vascular and clinical contributions. Psychol Med 2001;31:1403–1412. CrossRefGoogle ScholarPubMed
Arinami, T, Yamada, N, Yamakawa-Kobayashi, K, Hamaguchi, H, Toru, M. Methylenetetrahydrofolate reductase variant and schizophrenia/depression. Am J Med Genet 1997;74:526–528. 3.0.CO;2-E>CrossRefGoogle ScholarPubMed
Tan, EC, Chong, SA, Lim, LCet al. Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders. Psychiatr Genet 2004;14:227–231. CrossRefGoogle ScholarPubMed
Trinh, BN, Ong, CN, Coetzee, GA, Yu, MC, Laird, PW. Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels. Hum Genet 2002;111:299–302. CrossRefGoogle ScholarPubMed
Chang, HA, Lu, RB, Lin, WWet al. Lack of association between dopamine D3 receptor Ser9Gly polymorphism and schizophrenia in Han Chinese population. Acta Neuropsychiatrica 2007;19:344–350. CrossRefGoogle ScholarPubMed