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High frequency of clinical conditions commonly associated with mitochondrial disorders in schizophrenia

Published online by Cambridge University Press:  24 April 2020

Yolanda Alonso ,
Alba Valiente-Pallejà Open the ORCID record for Alba Valiente-Pallejà [Opens in a new window] ,
Begoña Verge ,
Elisabet Vilella  and
Lourdes Martorell Open the ORCID record for Lourdes Martorell [Opens in a new window]
Yolanda Alonso
Affiliation:
University Hospital Institut Pere Mata, Health Research Institute Pere Virgili (IISPV), Rovira i Virgili University (URV), Reus, Spain Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Alba Valiente-Pallejà
Affiliation:
University Hospital Institut Pere Mata, Health Research Institute Pere Virgili (IISPV), Rovira i Virgili University (URV), Reus, Spain Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Begoña Verge
Affiliation:
University Hospital Institut Pere Mata, Health Research Institute Pere Virgili (IISPV), Rovira i Virgili University (URV), Reus, Spain Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Elisabet Vilella
Affiliation:
University Hospital Institut Pere Mata, Health Research Institute Pere Virgili (IISPV), Rovira i Virgili University (URV), Reus, Spain Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
Lourdes Martorell*
Affiliation:
University Hospital Institut Pere Mata, Health Research Institute Pere Virgili (IISPV), Rovira i Virgili University (URV), Reus, Spain Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain
*
Author for correspondence: Lourdes Martorell, Email: [email protected]
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Abstract

Objective:

It has been hypothesised that neuropsychiatric symptoms, including psychosis, can be the result of a milder brain bioenergetic defect produced by mitochondrial dysfunction; however, mitochondrial dysfunction can be present in other organs or systems. The aim of the study was to investigate whether clinical conditions associated with mitochondrial disorders (CAMDs) were frequently present in schizophrenia.

Methods:

A previously used questionnaire regarding the CAMDs was administered to patients and controls in a direct interview with a trained psychiatrist. The frequencies of CAMDs in 164 patients with schizophrenia were compared to those in 156 age- and sex-matched controls.

Results:

Severe fatigue, seizures, constipation and diabetes were significantly more frequent in patients with schizophrenia than in control subjects and apparently not related to pharmacological treatment.

Conclusion:

The results of the present study suggest that multi-systemic mitochondrial dysfunction may be an underlying mechanism involved in schizophrenia.

Keywords

schizophreniamitochondrial diseasescomorbidityfatigueseizures
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 32 , Issue 5 , October 2020 , pp. 265 - 269
Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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