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Adjunctive use of interferon γ inducer for treatment of patients with schizophrenia

Published online by Cambridge University Press:  16 November 2015

Tamara Parfenovna Vetlugina ,
Olga Anatolyevna Lobacheva ,
Svetlana Alexandrovna Sergeeva ,
Valentina Borisovna Nikitina ,
Tatiana Ivanovna Nevidimova  and
Arkady Valentinovich Semke
Tamara Parfenovna Vetlugina*
Affiliation:
Department of Biological Psychiatry and Narcology, Mental Health Research Institute, Tomsk, Russian Federation
Olga Anatolyevna Lobacheva
Affiliation:
Laboratory of Psychoneuroimmunology, Mental Health Research Institute, Tomsk, Russian Federation
Svetlana Alexandrovna Sergeeva
Affiliation:
Open Joint-Stock Company ‘Russian Scientific Center for the Safety of Biologically Active Compounds’, Moscow, Russian Federation
Valentina Borisovna Nikitina
Affiliation:
Laboratory of Psychoneuroimmunology, Mental Health Research Institute, Tomsk, Russian Federation
Tatiana Ivanovna Nevidimova
Affiliation:
Laboratory of Psychoneuroimmunology, Mental Health Research Institute, Tomsk, Russian Federation
Arkady Valentinovich Semke
Affiliation:
Endogenous Disorders Department, Mental Health Research Institute, Tomsk, Russian Federation
*
Professor Tamara P. Vetlugina, Department of Biological Psychiatry and Narcology, Mental Health Research Institute, Tomsk, Russian Federation. Tel: +7 3822 724 415; Fax: +7 3822 724 425; E-mail: [email protected]
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Abstract

Objective

The present paper is devoted to evaluation of clinical and immunomodulatory effect of ultra-high dilutions of antibodies to human interferon γ, included in the complex therapy of patients with schizophrenia.

Materials and methods

The study was carried out at the Mental Health Research Institute, Tomsk, Russian Federation. This double-blind, placebo-controlled randomised in parallel-group study enrolled 40 patients. As a part of complex therapy, patients from the main group (n=20) received anaferon, a drug containing ultra-high dilutions of affinity-purified antibodies to human interferon γ as the active pharmaceutical ingredient; patients from the comparative group (n=20) received placebo. Duration of the therapy was 30±5 days. Assessment of severity of symptoms and changes in them were made using clinical scales: Positive and Negative Syndrome Scale, Clinical Global Impression, Abnormal Involuntary Movements Scale. Spontaneous and phytohemagglutinin-induced production of interferon γ by immunocompetent cells in supernatants of 48 h whole blood culture of patients was measured by enzyme-linked immunosorbent assay (ELISA) method.

Results

The reduction of interferon-producing potential by immunocompetent cells in comparison with reference normal value was shown in total group of patients (n=40) before combined therapy. During the treatment, increase of spontaneous interferon γ production and favourable changes in psychopathological symptoms as compared with placebo were shown in subjects receiving anaferon. It was found that favourable changes in clinical symptoms assessed using clinical scales with a high degree of confidence correlated with high level of spontaneous interferon γ production.

Conclusion

Anaferon as a part of complex therapy of patients with schizophrenia contributes to enhancement of its efficacy acting via mechanism of psychoimmunomodulation.

Keywords

interferon γpsychoneuroimmunologyschizophreniaultra-high dilutions of antibodies to human interferon γ
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 28 , Issue 3 , June 2016 , pp. 149 - 156
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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