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Acute administration of GLP-1 receptor agonists induces hypolocomotion but not anxiety in mice

Published online by Cambridge University Press:  24 June 2014

Maarja Krass ,
Kertu Rünkorg ,
Eero Vasar  and
Vallo Volke
Maarja Krass
Affiliation:
Department of Physiology, University of Tartu, 50411 Tartu, Estonia
Kertu Rünkorg
Affiliation:
Department of Physiology, University of Tartu, 50411 Tartu, Estonia
Eero Vasar
Affiliation:
Department of Physiology, University of Tartu, 50411 Tartu, Estonia
Vallo Volke*
Affiliation:
Department of Physiology, University of Tartu, 50411 Tartu, Estonia
*
Dr Vallo Volke, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia. Tel: +3727374338; Fax: +3727374332; E-mail: [email protected]
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Extract

Krass M, Rünkorg K, Vasar E, Volke V. Acute administration of GLP-1 receptor agonists induces hypolocomotion but not anxiety in mice.

Objective: The aim of this study was to compare the behavioural and hormonal effects of systemic (subcutaneous) treatment with glucaemically equipotent doses of exenatide and liraglutide in mice.

Methods: The effects of glucagon-like peptide-1 (GLP-1) receptor agonists were determined on anxiety level in the light–dark compartment test, the motor activity in automated activity cages and finally the forced swimming test was performed.

Results: Both exenatide (1–20 µg/kg) and liraglutide (200–1200 µg/kg) decreased the glucose levels up to 30% in freely fed animals. In glucaemically equipotent doses the drugs induced very similar behavioural and hormonal effects: there was no change on anxiety level or immobility time, however, both drugs suppressed motor activity and increased corticosterone levels.

Conclusion: We conclude that the two clinically approved GLP-1 receptor agonists induce very similar suppression of motor activity and stimulation of corticosterone release in mice.

Keywords

anxietycortisolneuroendocrinologystress
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 5 , October 2012 , pp. 296 - 300
Copyright
Copyright © Cambridge University Press 2012

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