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Mechanisms in Molecular Biology

Published online by Cambridge University Press:  05 October 2019

Tudor Baetu
Affiliation:
Université du Québec à Trois-Rivières

Summary

The new mechanistic philosophy is divided into two largely disconnected projects. One deals with a metaphysical inquiry into how mechanisms relate to issues such as causation, capacities and levels of organization, while the other deals with epistemic issues related to the discovery of mechanisms and the intelligibility of mechanistic representations. Tudor Baetu explores and explains these projects, and shows how the gap between them can be bridged. His proposed account is compatible both with the assumptions and practices of experimental design in biological research, and with scientifically accepted interpretations of experimental results.
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Online ISBN: 9781108592925
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Print publication: 10 October 2019

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References

Ankeny, R. 2001. “Model Organisms as Models: Understanding the ‘Lingua Franca’ of the Human Genome Project.” Philosophy of Science 68:S251S61.CrossRefGoogle Scholar
Ankeny, R., and Leonelli, S.. 2011. “What’s So Special about Model Organisms?” Studies in History and Philosophy of Science 42:313–23.CrossRefGoogle Scholar
Anscombe, G. E. M. 1993. “Causality and Determination.” In Causation, ed. Sosa, E. and Tooley, M.. Oxford: Oxford University Press.Google Scholar
Asmundson, G. J. G., and Wright, K. D.. 2004. “Biopsychosocial Approaches to Pain.” In Pain: Psychological Perspectives, ed. Hadjistavropoulos, T. and Craig, K. D.. Mahwah, NJ: Lawrence Erlbaum Associates.Google Scholar
Baetu, T. M. 2012a. “Filling In the Mechanistic Details: Two-Variable Experiments as Tests for Constitutive Relevance.” European Journal for Philosophy of Science 2 (3):337–53.CrossRefGoogle Scholar
Baetu, T. M. 2012b. “Mechanistic Constraints on Evolutionary Outcomes.” Philosophy of Science 79 (2):276–94.CrossRefGoogle Scholar
Baetu, T. M. 2013. “Chance, Experimental Reproducibility, and Mechanistic Regularity.” International Studies in History and Philosophy of Science 27 (3):255–73.Google Scholar
Baetu, T. M. 2014. “Models and the Mosaic of Scientific Knowledge. The Case of Immunology.” Studies in History and Philosophy of Biological and Biomedical Sciences 45:4956.CrossRefGoogle Scholar
Baetu, T. M. 2015a. “From Mechanisms to Mathematical Models and Back to Mechanisms: Quantitative Mechanistic Explanations.” In Explanation in Biology. An Enquiry into the Diversity of Explanatory Patterns in the Life Sciences, ed. Braillard, P.-A. and Malaterre, C., 345–63. Dordrecht: Springer.Google Scholar
Baetu, T. M. 2015b. “When Is a Mechanistic Explanation Satisfactory? Reductionism and Antireductionism in the Context of Mechanistic Explanations.” In Romanian Studies in the History and Philosophy of Science, ed. Sandu, G., Parvu, I. and Toader, I.. Dordrecht: Springer.Google Scholar
Baetu, T. M. 2016a. “The ‘Big Picture’: The Problem of Extrapolation in Basic Research.” British Journal for the Philosophy of Science 67 (4):941–64.CrossRefGoogle Scholar
Baetu, T. M. 2016b. “From Interventions to Mechanistic Explanations.” Synthese 193:3311–27.CrossRefGoogle Scholar
Baetu, T. M. 2017a. “Mechanisms in Molecular Biology.” In Routledge Handbook of Mechanisms, ed. Glennan, Stuart and Phyllis, Illari. New York: Routledge.Google Scholar
Baetu, T. M. 2017b. “On Pain Experience, Interdisciplinary Integration and Levels of Description, Explanation and Reality.” Synthese DOI 10.1007/s11229-017–1429–5.Google Scholar
Baetu, T. M. 2017c. “On the Possibility of Designing Crucial Experiments in Biology.” British Journal for the Philosophy of Science.Google Scholar
Baetu, T. M. 2019. “On the Possibility of Designing Crucial Experiments in Biology.” British Journal for the Philosophy of Science 70 (2):407–429.CrossRefGoogle Scholar
Ball, P. 2011. “Physics of Life: The Dawn of Quantum Biology.” Nature 474 (7351):272–74.CrossRefGoogle ScholarPubMed
Barwich, A.-S. 2015. “Bending Molecules or Bending the Rules: The Application of Theoretical Models in Fragrance Chemistry.” Perspectives on Science 23 (4):123.CrossRefGoogle Scholar
Bates, G. P. 2005. “The Molecular Genetics of Huntington Disease – A History.” Nature Reviews Genetics 6:766–73.CrossRefGoogle Scholar
Baumgartner, M., and Gebharter, A.. 2016. “Constitutive Relevance, Mutual Manipulability, and Fat-Handedness.” British Journal for the Philosophy of Science 67:731–56.CrossRefGoogle Scholar
Bechtel, W. 2006. Discovering Cell Mechanisms: The Creation of Modern Cell Biology. Cambridge: Cambridge University Press.Google Scholar
Bechtel, W. 2008. Mental Mechanisms: Philosophical Perspectives on Cognitive Neuroscience. New York: Routledge.Google Scholar
Bechtel, W. 2009. “Generalization and Discovery by Assuming Conserved Mechanisms: Cross Species Research on Circadian Oscillators.” Philosophy of Science 76:762–73.CrossRefGoogle Scholar
Bechtel, W. 2011. “Mechanism and Biological Explanation.” Philosophy of Science 78:533–57.CrossRefGoogle Scholar
Bechtel, W., and Abrahamsen, A.. 2005. “Explanation: A Mechanist Alternative.Studies in History and Philosophy of Biological and Biomedical Sciences 36:421–41.CrossRefGoogle ScholarPubMed
Bechtel, W., and Abrahamsen, A. 2010. “Dynamic Mechanistic Explanation: Computational Modeling of Circadian Rhythms as an Exemplar for Cognitive Science.Studies in History and Philosophy of Science Part A 41:321–33.CrossRefGoogle ScholarPubMed
Bechtel, W., and Richardson, R.. 2010. Discovering Complexity: Decomposition and Localization as Strategies in Scientific Research. Cambridge: Massachusetts Institute of Technology Press.CrossRefGoogle Scholar
Bickle, J. 2006. “Reducing Mind to Molecular Pathways: Explicating the Reductionism Implicit in Current Cellular and Molecular Neuroscience.Synthese 151:411–34.CrossRefGoogle Scholar
Bogen, J. 2004. “Analyzing Causality: The Opposite of Counterfactual is Factual.International Studies in the Philosophy of Science 18:326.CrossRefGoogle Scholar
Bogen, J. 2005. “Regularities and Causality; Generalizations and Causal Explanations.” Studies in History and Philosophy of Biological and Biomedical Sciences 36:397420.CrossRefGoogle Scholar
Bogen, J. 2008. “Causally Productive Activities.” Studies in History and Philosophy of Science 39:112–23.CrossRefGoogle Scholar
Bogen, J., and Woodward, J.. 1988. “Saving the Phenomena.” The Philosophical Review 97 (3):303–52.CrossRefGoogle Scholar
Botting, R. M. 2010. “Vane’s Discovery of the Mechanism of Action of Aspirin Changed Our Understanding of Its Clinical Pharmacology.” Pharmacological Reports 62:518–25.CrossRefGoogle Scholar
Braillard, P.-A. 2014. “Prospect and Limits of Explaining Biological Systems in Engineering Terms.” In Explanation in Biology. An Enquiry into the Diversity of Explanatory Patterns in the Life Sciences, ed. Braillard, P.-A. and Malaterre, C.. Dordrecht: Springer.Google Scholar
Bridgman, P. 1927. The Logic of Modern Physics. New York: Macmillan.Google Scholar
Broadbent, A. 2013. Philosophy of Epidemiology. Houndmills: Palgrave Macmillan.CrossRefGoogle Scholar
Brooks, D. S. 2017. “In Defense of Levels: Layer Cakes and Guilt by Association.” Biological Theory 12 (3):142–56.CrossRefGoogle Scholar
Brown, J. R. 1994. Smoke and Mirrors: How Science Reflects Reality. London: Routledge.CrossRefGoogle Scholar
Brune, K., and Hinz, B.. 2004. “The Discovery and Development of Antiinflammatory Drugs.” Arthritis & Rheumatism 50 (8):2391–99.CrossRefGoogle ScholarPubMed
Burnham, K. P., and Anderson, D. R.. 2002. Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach. 2nd ed. New York: Springer.Google Scholar
Cartwright, N. 1989. Nature’s Capacities and Their Measurement. Oxford: Oxford University Press.Google Scholar
Cohn, M., and Tickle, C.. 1999. “Developmental Basis of Limblessness and Axial Patterning in Snakes.” Nature 399:474–79.CrossRefGoogle Scholar
Craver, C. 2001. “Role Functions, Mechanisms, and Hierarchy.” Philosophy of Science 68:5374.CrossRefGoogle Scholar
Craver, C. 2007. Explaining the Brain: Mechanisms and the Mosaic Unity of Neuroscience. Oxford: Clarendon Press.CrossRefGoogle Scholar
Craver, C., and Bechtel, W.. 2007. “Top-Down Causation without Top-Down Causes.” Biology and Philosophy 22:547–63.CrossRefGoogle Scholar
Craver, C., and Darden, L.. 2013. In Search of Biological Mechanisms: Discoveries across the Life Sciences. Chicago: University of Chicago Press.CrossRefGoogle Scholar
Cremer, T., and Cremer, C.. 2001. “Chromosome Territories, Nuclear Architecture and Gene Regulation in Mammalian Cells.” Nature Reviews Genetics 2:292301.CrossRefGoogle Scholar
Cummins, R. 1975. “Functional Analysis.” Journal of Philosophy 72 (20):741–65.CrossRefGoogle Scholar
Cummins, R. 2000. “‘How Does It Work’ Versus ‘What Are the Laws?’: Two Conceptions of Psychological Explanation.” In Explanation and Cognition, ed. Keil, F. and Wilson, R., 117–45. Cambridge: Massachusetts Institute of Technology Press.Google Scholar
Darden, L. 1991. Theory Change in Science: Strategies from Mendelian Genetics. New York: Oxford University Press.CrossRefGoogle Scholar
Darden, L. 2006a. “Flow of Information in Molecular Biological Mechanisms.” Biological Theory 1 (3):280–87.CrossRefGoogle Scholar
Darden, L. 2006b. Reasoning in Biological Discoveries: Essays on Mechanisms, Interfield Relations, and Anomaly Resolution. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Darden, L. 2008. “Thinking Again about Biological Mechanisms.” Philosophy of Science 75:958–69.CrossRefGoogle Scholar
Davidson, E., and Levine, M.. 2005. “Gene Regulatory Networks.” Proceedings of the National Academy of Science 102 (14):4935.CrossRefGoogle ScholarPubMed
Dowe, P. 1995. “Causality and Conserved Quantities: A Reply to Salmon.Philosophy of Science 62:321–33.CrossRefGoogle Scholar
Ellis, J. 2001. “Macromolecular Crowding: Obvious but Underappreciated.” Trends in Biochemical Sciences 26 (10):597604.CrossRefGoogle ScholarPubMed
Elowitz, M., Levine, A. J., Siggia, E. D., and Swain, P. S.. 2002. “Stochastic Gene Expression in a Single Cell.” Science 297 (5584):1183–86.CrossRefGoogle Scholar
Fagan, M. B. 2012. “The Joint Account of Mechanistic Explanation.” Philosophy of Science 79 (4):448–72.Google Scholar
Fisher, R. A. 1935. The Design of Experiments. Edinburgh: Oliver and Boyd.Google Scholar
Frith, C. D. 1992. The Cognitive Neuropsychology of Schizophrenia. Hove: Lawrence Erlbaum Associates.Google Scholar
Germain, P.-L., and Baetu, T. M.. 2017. “Extrapolation in Biomedical Research: A Multi-Model Perspective.” In Foundational Issues in Molecular Medicine, ed. Nathan, Marco and Giovanni, Boniolo. New York: Routledge.Google Scholar
Glennan, S. 1996. “Mechanisms and the Nature of Causation.” Erkenntnis 44:4971.CrossRefGoogle Scholar
Glennan, S. 2002. “Rethinking Mechanistic Explanation.” Philosophy of Science 69:S342S53.CrossRefGoogle Scholar
Glennan, S. 2010. “Ephemeral Mechanisms and Historical Explanation.” Erkenntnis 72:251–66.CrossRefGoogle Scholar
Glennan, S. 2011. “Singular and General Causal Relations: A Mechanist Perspective.” In Causality in the Sciences, ed. McKay, P., Williamson, J. and Russo, F., 789817. Oxford: Oxford University Press.CrossRefGoogle Scholar
Glennan, S. 2017. The New Mechanical Philosophy. New York: Oxford University Press.CrossRefGoogle Scholar
Goodsell, D. S. 2009. The Machinery of Life. 2nd ed. New York: Copernicus Books.CrossRefGoogle Scholar
Gori, G. B. 1989. “Epidemiology and the Concept of Causation in Multifactorial Diseases.” Regulatory Toxicology and Pharmacology 9 (3):263–72.Google ScholarPubMed
Gross, F. 2015. “The Relevance of Irrelevance: Explanation in Systems Biology.” In Explanation in Biology. An Enquiry into the Diversity of Explanatory Patterns in the Life Sciences, ed. Braillard, P.-A. and Malaterre, C.. Dordrecht: Springer.Google Scholar
Hacking, I. 1983. Representing and Intervening. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Hacking, I. 1990. The Taming of Chance. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Hall, N. 2004. “Two Concepts of Causation.” In Causation and Counterfactuals, ed. Collins, J., Hall, N., and Paul, L., 225–76. Cambridge, MA: Massachusetts Institute of Technology Press.Google Scholar
Harinen, T. 2014. “Mutual Manipulability and Causal Inbetweenness.” Synthese 195 (1):3454.Google Scholar
Hendry, R. F. 2008. “Two Conceptions of the Chemical Bond.” Philosophy of Science 75 (5):909–20.CrossRefGoogle Scholar
Hill, A. B. 1955. Principles of Medical Statistics. 6th ed. New York: Oxford University Press.Google Scholar
Hill, A. B. 1965. “The Environment and Disease: Association or Causation?” Proceedings of the Royal Society of Medicine 58:295300.CrossRefGoogle Scholar
Hochachka, P. W. 1999. “The Metabolic Implications of Intracellular Circulation.” Proceedings of the National Academy of Sciences 96 (22):12233–39.CrossRefGoogle ScholarPubMed
Hoffmann, A., Levchenko, A., Scott, M., and Baltimore, D.. 2002. “The IκB–NF-κB Signaling Module: Temporal Control and Selective Gene Activation.” Science 298:1241–45.CrossRefGoogle Scholar
Hoffmann, P. M. 2012. Life’s Ratchet: How Molecular Machines Extract Order from Chaos. New York: Basic Books.Google Scholar
Hohwy, J. 2007. “The Search for Neural Correlates of Consciousness.” Philosophy Compass 2 (3):461–74.CrossRefGoogle Scholar
Holmes, F. L. 2001. Meselson, Stahl, and the Replication of DNA: A History of the Most Beautiful Experiment in Biology. New Haven: Yale University Press.CrossRefGoogle Scholar
Holmes, F. L. 2006. Reconceiving the Gene: Seymour Benzer’s Adventures in Phage Genetic. New Haven: Yale University Press.Google Scholar
Howick, J. 2011. The Philosophy of Evidence-Based Medicine. Oxford: BMJ Books.CrossRefGoogle Scholar
Illari, P., and Williamson, J.. 2011. “Mechanisms Are Real and Local.” In Causality in the Sciences, ed. McKay Illari, P., Russo, F., and Williamson, J., 818–44. Oxford: Oxford University Press.CrossRefGoogle Scholar
Illari, P., and Williamson, J. 2012. “What Is a Mechanism? Thinking about Mechanisms across the Sciences.” European Journal for Philosophy of Science 2 (1):119–35.CrossRefGoogle Scholar
Issad, T., and Malaterre, C.. 2015. “Mechanisms, Models and Explanatory Force.” In Explanation in Biology. An Enquiry into the Diversity of Explanatory Patterns in the Life Sciences, ed. Braillard, P.-A. and Malaterre, C.. Dordrecht: Springer.Google Scholar
Jocher, A., Kessler, S., Hornstein, S., Schulte Mönting, J., and Schempp, C. M.. 2005. “The UV Erythema Test as a Model to Investigate the Anti-Infl ammatory Potency of Topical Preparations – Reevaluation and Optimization of the Method.” Skin Pharmacology and Physiology 18:234–40.CrossRefGoogle Scholar
Kaiser, M. I., and Krickel, B.. 2017. “The Metaphysics of Constitutive Mechanistic Phenomena.” British Journal for the Philosophy of Science 68 (3):745–79.CrossRefGoogle Scholar
Kendall, R. E. 2001. “The Distinction between Mental and Physical Illness.” The British Journal of Psychiatry 178 (6):490–93.Google Scholar
Kendler, K. S., and Campbell, J.. 2009. “Interventionist Causal Models in Psychiatry: Repositioning the Mind-Body Problem.” Psychological Medicine 39:881–87.CrossRefGoogle Scholar
Kim, J. 2005. Physicalism or Something Near Enough Princeton, NJ: Princeton University Press.Google Scholar
Koch, C., Massimini, M., Boly, M., and Tononi, G.. 2016. “Neural Correlates of Consciousness: Progress and Problems.” Nature Reviews Neuroscience 17 (5):307–21.Google ScholarPubMed
Krieger, N. 1994. “Epidemiology and the Web of Causation: Has Anyone Seen the Spider?” Social Science & Medicine 39 (7):887903.CrossRefGoogle Scholar
Kupiec, J.-J., Gandrillon, O., Morange, M., and Silberstein, M., eds. 2011. Le hasard au coeur de la cellule: Probabilités, déterminisme, génétique. Paris: Éditions Matériologiques.CrossRefGoogle Scholar
Langenbach, R., Loftin, C. D., Lee, C., and Tiano, H.. 1999. “Cyclooxygenase-Deficient Mice. A Summary of Their Characteristics and Susceptibilities to Inflammation and Carcinogenesis.” Annals of the New York Academy of Sciences 889:5261.CrossRefGoogle Scholar
Leighton, J. P. 2010. “Internal Validity.” In Encyclopedia of Research Design, ed. Salkind, N. J.. Thousand Oaks, CA: Sage.Google Scholar
Leuridan, B. 2012. “Three Problems for the Mutual Manipulability Account of Constitutive Relevance in Mechanisms.” British Journal for the Philosophy of Science 63:399427.CrossRefGoogle Scholar
Love, A. 2012. “Hierarchy, Causation and Explanation: Ubiquity, Locality and Pluralism.” Interface Focus 2:115–25.CrossRefGoogle Scholar
Machamer, P. 2004. “Activities and Causation: The Metaphysics and Epistemology of Mechanisms.” International Studies in the Philosophy of Science 18 (1):2739.CrossRefGoogle Scholar
Machamer, P., Darden, L., and Craver, C.. 2000. “Thinking About Mechanisms.” Philosophy of Science 67:125.CrossRefGoogle Scholar
Mathews, C. K. 1993. “The Cell-Bag of Enzymes or Network of Channels?” Journal of Bacteriology 175 (20):6377–81.CrossRefGoogle Scholar
McAllister, J. W. 1997. “Phenomena and Patterns in Data Sets.” Erkenntnis 47:217–28.CrossRefGoogle Scholar
McAllister, J. W. 2007. “A Mechanistic Meeting Point.” Nature Chemical Biology 3 (3):127.Google Scholar
Menzies, P. 1996. “Probabilistic Causation and the Pre-Emption Problem.” Mind 105 (417):85117.CrossRefGoogle Scholar
Mill, J. S. 1843. A System of Logic, Ratiocinative and Inductive. London: John W. Parker.Google Scholar
Morange, M. 2002. “The Gene: Between Holism and Generalism.” In Promises and Limits of Reductionism in the Biomedical Sciences, ed. Van Regenmortel, M. and Hull, D.. Chichester: John Wiley & Sons.Google Scholar
Morange, M. 2009. “Synthetic Biology: A Bridge between Functional and Evolutionary Biology.” Biological Theory 4 (4):368–77.CrossRefGoogle Scholar
Morris, R. G. M. 1981. ” Spatial Localization Does Not Require the Presence of Local Cues.” Learning and Motivation 12 (2):239–60.CrossRefGoogle Scholar
Murphy, D. 2006. Psychiatry in the Scientific Image. Cambridge, MA: Massachusetts Institute of Technology Press.Google Scholar
Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L, Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., Nowak, K. L., O’Neill, L. A., Pickkers, P., van der Poll, T., Ridker, P. M., Schalkwijk, J., Schwartz, D. A., Siegmund, B., Steer, C. J., Tilg, H., van der Meer, J. W. M., van de Veerdonk, F. L., and Dinarello, C. A.. 2017. “A Guiding Map for Inflammation.” Nature Immunology 18:826–31.CrossRefGoogle Scholar
Philips, R., and Quake, S. R.. 2006. “The Biological Frontier of Physics.” Physics Today 59: 3843.CrossRefGoogle Scholar
Potochnik, A., and McGill, B.. 2012. “The Limitations of Hierarchical Organization.” Philosophy of Science 79 (1):120–40.CrossRefGoogle Scholar
Ptashne, M. A. 1998. Genetic Switch: Phage Lambda and Higher Organisms. Cambridge, MA: Blackwell Scientific Publications.Google Scholar
Rainsford, K. 2015. “History and Development of Ibuprofen.” In Ibuprofen: Discovery, Development and Therapeutics, ed. Rainsford, K., 121. Chichester: John Wiley & Sons.CrossRefGoogle Scholar
Rao, C. V., Wolf, D. M., and Arkin, A. P.. 2002. “Control, Exploitation and Tolerance of Intracellular Noise.” Nature 420 (6912):231–37.CrossRefGoogle ScholarPubMed
Romero, F. 2015. “Why There Isn’t Inter-Level Causation in Mechanisms.” Synthese 192:3731–55.CrossRefGoogle Scholar
Rosenberg, A. 2006. Darwinian Reductionism, or, How to Stop Worrying and Love Molecular Biology. Chicago: University of Chicago Press.CrossRefGoogle Scholar
Salmon, W. 1984. Scientific Explanation and the Causal Structure of the World. Princeton: Princeton University Press.Google Scholar
Salmon, W. 1997. “Causality and Explanation: A Reply to Two Critiques.Philosophy of Science 64:461–77.CrossRefGoogle Scholar
Schaffner, K. F. 1993. Discovery and Explanation in Biology and Medicine. Chicago: University of Chicago Press.Google Scholar
Scholl, B. J., and Tremoulet, P. D.. 2000. “Perceptual Causality and Animacy.” Trends in Cognitive Sciences 4 (8):299309.CrossRefGoogle ScholarPubMed
Schwarz, H. P., and Dorner, F.. 2003. “Karl Landsteiner and His Major Contributions to Haematology.” British Journal of Haematology 121 (4):556–65.CrossRefGoogle Scholar
Smart, J. J. C. 1959. “Sensations and Brain Processes.” Philosophical Review 68:141–56.CrossRefGoogle Scholar
Smyth, J. M., Ockenfels, M. C., Gorin, A. A., Catley, D., Porter, L. S., Kirschbaum, C., Hellhammer, D. H., and Stone, A. A.. 1997. “Individual Differences in the Diurnal Cycle of Cortisol.” Psychoneuroendocrinology 22 (2):89105.CrossRefGoogle ScholarPubMed
Spearman, C. E. 1904. “‘General Intelligence’, Objectively Determined and Measured.” American Journal of Psychology 15:201–93.Google Scholar
Steel, D. 2007. Across the Boundaries: Extrapolation in Biology and Social Science. Oxford: Oxford University Press.CrossRefGoogle Scholar
Stigler, S. M. 1986. The History of Statistics. Cambridge, MA: Harvard University Press.Google Scholar
Sun, S.-C., Ganchi, P. A., Ballard, D. W., and Greene, W. C.. 1993. “NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway.Science 259:1912–15.CrossRefGoogle Scholar
Tabery, J. 2004. “Synthesizing Activities and Interactions in the Concept of a Mechanism.” Philosophy of Science 71:115.CrossRefGoogle Scholar
Tabery, J. 2009. “Difference Mechanisms: Explaining Variation with Mechanisms.” Biology and Philosophy (in press).CrossRefGoogle Scholar
Taylor, J. R. 1997. Introduction to Error Analysis: The Study of Uncertainties in Physical Measurements. Sausalito, CA: University Science Books.Google Scholar
Trout, J. D. 1998. Measuring the Intentional World: Realism, Naturalism, and Quantitative Methods in the Behavioral Sciences. Oxford: Oxford University Press.CrossRefGoogle Scholar
Waters, C. K. 2007. “Causes That Make a Difference.” The Journal of Philosophy 104 (11):551–79.CrossRefGoogle Scholar
Weber, M. 2005. Philosophy of Experimental Biology. Cambridge: Cambridge University Press.Google Scholar
Wimsatt, W. C. 2007. Re-engineering Philosophy for Limited Beings: Piecewise Approximations to Reality. Cambridge, MA: Harvard University Press.CrossRefGoogle Scholar
Woodward, J. 2002. “What Is a Mechanism? A Counterfactual Account.” Philosophy of Science 69:S366S77.CrossRefGoogle Scholar
Woodward, J. 2003. Making Things Happen: A Theory of Causal Explanation. Oxford: Oxford University Press.Google Scholar
Woodward, J. 2008. “Cause and Explanation in Psychiatry: An Interventionist Perspective.” In Philosophical Issues in Psychiatry: Explanation, Phenomenology and Nosology, ed. Kendler, K. and Parnas, J.. Baltimore: Johns Hopkins University Press.Google Scholar
Ylikoski, P. 2013. “Causal and Constitutive Explanation Compared.” Erkenntnis 78:277–97.CrossRefGoogle Scholar

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Mechanisms in Molecular Biology
  • Tudor Baetu, Université du Québec à Trois-Rivières
  • Online ISBN: 9781108592925
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  • Tudor Baetu, Université du Québec à Trois-Rivières
  • Online ISBN: 9781108592925
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Mechanisms in Molecular Biology
  • Tudor Baetu, Université du Québec à Trois-Rivières
  • Online ISBN: 9781108592925
Available formats
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