Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-11-25T02:29:40.055Z Has data issue: false hasContentIssue false

Cranial and Spinal Tuberculosis Infections including Acute Presentations

Published online by Cambridge University Press:  24 April 2024

Veekshith Shetty
Affiliation:
Manipal Hospital, Bangalore
Pragnesh Bhatt
Affiliation:
Aberdeen Royal Infirmary

Summary

Central nervous system, affliction, although rare, represents one of the most severe extra-pulmonary manifestations of tuberculosis, potentially leading to substantial morbidity and mortality if not promptly addressed. Cranial tuberculosis can manifest in various forms, including tuberculomas, encephalitis, abscesses, and meningitis, with the latter being the most critical and carrying a poor prognosis if left untreated. Spinal tuberculosis, accounting for approximately 50% of musculoskeletal TB cases, can present with a spectrum of symptoms, ranging from simple back pain to more severe neurological deficits such as weakness and deformity. Anti-tuberculosis medications remain the cornerstone of treatment, and this Element offers an algorithmic approach to managing referrals of suspected tuberculosis, incorporating pertinent clinical information to facilitate effective decision-making.
Get access
Type
Element
Information
Online ISBN: 9781009388764
Publisher: Cambridge University Press
Print publication: 16 May 2024

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Thwaites, G, Fisher, M, Hemingway, C, et al. British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect. 2009;59(3):167–87.CrossRefGoogle ScholarPubMed
Navarro-Flores, A, Fernandez-Chinguel, JE, Pacheco-Barrios, N, Soriano-Moreno, DR, Pacheco-Barrios, K. Global morbidity and mortality of central nervous system tuberculosis: A systematic review and meta-analysis. J Neurol. 2022;269(7):3482–94.CrossRefGoogle ScholarPubMed
Rich, GJ. Some relationships between personality and body chemistry. J Neurol Psychopathol. 1933;14(54):132–8.Google ScholarPubMed
Muzumdar, D, Vedantam, R, Chandrashekhar, D. Tuberculosis of the central nervous system in children. Childs Nerv Syst. 2018;34(10):1925–35.CrossRefGoogle ScholarPubMed
Schaller, MA, Wicke, F, Foerch, C, Weidauer, S. Central nervous system tuberculosis: Etiology, clinical manifestations and neuroradiological features. Clin Neuroradiol. 2019;29(1):318.CrossRefGoogle ScholarPubMed
Chatterjee, S. Brain tuberculomas, tubercular meningitis, and post-tubercular hydrocephalus in children. J Pediatr Neurosci. 2011;6(Suppl 1):S96–S100.CrossRefGoogle ScholarPubMed
Hernandez, AV, de Laurentis, L, Souza, I, et al. Diagnostic accuracy of Xpert MTB/RIF for tuberculous meningitis: Systematic review and meta-analysis. Trop Med Int Health. 2021;26(2):122–32.CrossRefGoogle ScholarPubMed
Bernaerts, A, Vanhoenacker, FM, Parizel, PM, et al. Tuberculosis of the central nervous system: Overview of neuroradiological findings. Eur Radiol. 2003;13(8):1876–90.CrossRefGoogle ScholarPubMed
Hsieh, FY, Chia, LG, Shen, WC. Locations of cerebral infarctions in tuberculous meningitis. Neuroradiology. 1992;34(3):197–9.CrossRefGoogle ScholarPubMed
Wang, MG, Luo, L, Zhang, Y, et al. Treatment outcomes of tuberculous meningitis in adults: A systematic review and meta-analysis. BMC Pulm Med. 2019;19(1):111.CrossRefGoogle ScholarPubMed
Rajshekhar, V. Surgery for brain tuberculosis: A review. Acta Neurochir (Wien). 2015;157(10):1665–78.CrossRefGoogle ScholarPubMed
WHO. Tuberculosis surveillance and monitoring in Europe 2021: 2019 data. 2021.Google Scholar
Garg, RK, Somvanshi, DS. Spinal tuberculosis: A review. J Spinal Cord Med. 2011;34(5):440–54.CrossRefGoogle ScholarPubMed
Khanna, K, Sabharwal, S. Spinal tuberculosis: A comprehensive review for the modern spine surgeon. Spine J. 2019;19(11):1858–70.CrossRefGoogle ScholarPubMed
Rajasekaran, S. The natural history of post-tubercular kyphosis in children: Radiological signs which predict late increase in deformity. J Bone Joint Surg Br. 2001;83(7):954–62.CrossRefGoogle ScholarPubMed
Trecarichi, EM, Di Meco, E, Mazzotta, V, Fantoni, M. Tuberculous spondylodiscitis: Epidemiology, clinical features, treatment, and outcome. Eur Rev Med Pharmacol Sci. 2012;16(Suppl 2):5872.Google ScholarPubMed
Shetty, A, Kanna, RM, Rajasekaran, S, editors. TB spine – Current aspects on clinical presentation, diagnosis, and management options. Seminars in Spine Surgery; 2016: Elsevier.Google Scholar
Jutte, PC, van Loenhout‐Rooyackers, JH. Routine surgery in addition to chemotherapy for treating spinal tuberculosis. Cochrane Database of Systematic Reviews. 2006(1).Google Scholar

Save element to Kindle

To save this element to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Cranial and Spinal Tuberculosis Infections including Acute Presentations
Available formats
×

Save element to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Cranial and Spinal Tuberculosis Infections including Acute Presentations
Available formats
×

Save element to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Cranial and Spinal Tuberculosis Infections including Acute Presentations
Available formats
×