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Series:   Elements in Molecular Oncology

Personalized Drug Screening for Functional Tumor Profiling

Published online by Cambridge University Press:  10 June 2022

Victoria El-Khoury ,
Tatiana Michel ,
Hichul Kim  and
Yong-Jun Kwon
Victoria El-Khoury
Affiliation:
Luxembourg Institute of Health
Tatiana Michel
Affiliation:
Luxembourg Institute of Health
Hichul Kim
Affiliation:
Luxembourg Institute of Health
Yong-Jun Kwon
Affiliation:
Luxembourg Institute of Health

Summary

Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology.
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Keywords

targeted therapypersonalized medicineprecision medicinedrug screeningpersonalized functional profiling
Type
Element
Information
Series: Elements in Molecular Oncology
Online ISBN: 9781009037877
Publisher: Cambridge University Press
Print publication: 07 July 2022

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