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  1. Home
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  3. Half a Century of Free Radical Chemistry
  • Cited by 53
Publisher:
Cambridge University Press
Online publication date:
October 2009
Print publication year:
1993
Online ISBN:
9780511564383
DOI:
https://doi.org/10.1017/CBO9780511564383
Subjects:
Mathematics (general), Organic Chemistry, Chemistry
Series:
Lezioni Lincee
Information

Book description

This book describes the experience over 25 years of the senior author with the chemistry of organic free radicals. It begins with a mechanistic study of industrial importance on the pyrolysis of chlorinated alkanes. It continues with a theory on the biosynthesis of phenolate derived alkaloids involving phenolate radical coupling. There follows 20 years of practical work to prove the theory correct, especially in the case of morphine alkaloids. The book then describes the work on nitrile photolysis (Barton reaction) which involved the invention of new radical chemistry leading to a simple synthesis of the important hormone, aldosterone. There follows a description of the invention of an important new method for the deoxygenation of biologically important molecules, especially sugars and nucleosides, using radical chemistry applied to thiocarbonyl derivatives. Some years later, in a logical extension to carboxylic acids, another new reaction was invented which provides carbon, nitrogen, oxygen and other radicals under mild conditions. A final chapter summarizes recent applications of thiocarbonyl group derived radical reactions by other authors.

Reviews

‘ … a very useful book both for the specialist radical fraternity and for those engaged in modern organic synthesis … (will) inspire young scientists interested in the creative cross-linking process of invention.’

Source: Chemistry in Britain

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