This text on general relativity and its modern applications is suitable for an intensive one-semester course on general relativity, at the level of a Ph.D. student in physics. Assuming knowledge of classical mechanics and electromagnetism at an advanced undergraduate level, basic concepts are introduced quickly, with greater emphasis on their applications. Standard topics are covered, such as the Schwarzschild solution, classical tests of general relativity, gravitational waves, ADM parametrization, relativistic stars and cosmology, as well as more advanced standard topics like vielbein-spin connection formulation, trapped surfaces, the Raychaudhuri equation, energy conditions, the Petrov and Bianchi classifications and gravitational instantons. More modern topics, including black hole thermodynamics, gravitational entropy, effective field theory for gravity, the PPN expansion, the double copy and fluid-gravity correspondence, are also introduced using the language understood by physicists, without too abstract mathematics, proven theorems, or the language of pure mathematics.