Fetal Tissue Transplants in Medicine

doi:10.1017/CBO9781139043762

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Edited by Robert G. Edwards

Publisher:: Cambridge University Press
Print publication year:: 1992
Online ISBN:: 9781139043762
DOI:: https://doi.org/10.1017/CBO9781139043762

Subjects:: Life Sciences, Obstetrics and Gynecology, Reproductive Medicine, Medicine, Biological Anthropology and Primatology

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Professor Edwards is a pioneer of much of the research in applied human embryology, making a significant and invaluable contribution to knowledge in this field. In this 1992 book, he brought together the research experience of prominent scientists and clinicians. The most advanced scientific and clinical developments and techniques were presented, including both the transplantation of fetal tissue into mature recipients and the grafting of donor cells into fetuses known to be carrying a genetic disease. The successes and failures of these techniques as a clinical treatment and therapeutic tool are discussed. The book begins with an overview of embryologic devlopment: from fertilization to differentiation of cell lines and organogenesis. The transplantation of specific cell lines and tissue types is then considered. Transplantation techniques, donor–host interactions and immunology, cell and tissue storage are all discussed, as are the ethical issues and the legal implications.

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Fetal Tissue Transplants in Medicine

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

List of contributors
pp ix-x

Preface
pp xi-xii

1 - Differentiation and transplantation of embryonic cells in mammals
pp 1-50

2 - Organogenesis and central nervous system development
pp 51-76

3 - Experimental human hematopoiesis in immunodeficient SCID mice engrafted with fetal blood-forming organs
pp 77-96

4 - Ontogeny of human T- and B-cell immunity
pp 97-128

5 - The procurement of human fetal tissues for clinical transplantation. Practice and problems
pp 129-154

6 - Transplantation of fetal haemopoietic and lymphopoietic cells in humans, with special reference to in utero transplantation
pp 155-176

7 - The biology of fetal brain tissue grafts: from mouse to man
pp 177-214

8 - Clinical results of transplanting fetal pancreas
pp 215-238

9 - The suitability of fetal and infantile donors for corneal transplantation
pp 239-252

10 - Transplantation of ovaries and testes
pp 253-280

11 - Cell grafting and gene therapy in metabolic diseases
pp 281-298

12 - The low temperature preservation of fetal cells
pp 299-322

13 - Law and ethics of transplanting fetal tissue
pp 323-330

Appendix: Code of practice on the use of fetuses and fetal material in research and treatment
pp 331-336

Brief bibliography on various aspects of transplanting fetal 337 tissue
pp 337-346

Index
pp 347-352

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